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Flrt1 fibronectin leucine rich transmembrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 396184, updated on 26-Sep-2022

Summary

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Official Symbol
Flrt1provided by MGI
Official Full Name
fibronectin leucine rich transmembrane protein 1provided by MGI
Primary source
MGI:MGI:3026647
See related
Ensembl:ENSMUSG00000047787 AllianceGenome:MGI:3026647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D630040I23Rik
Summary
Enables fibroblast growth factor receptor binding activity. Involved in dendrite development; fibroblast growth factor receptor signaling pathway; and neuron projection extension. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including neuron projection terminus; neuronal cell body membrane; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Colocalizes with focal adhesion. Is expressed in several structures, including central nervous system; embryo mesenchyme; gut; neural ectoderm; and sensory organ. Orthologous to human FLRT1 (fibronectin leucine rich transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 10.2), cortex adult (RPKM 2.7) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Flrt1 in Genome Data Viewer
Location:
19; 19 A
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7064829..7143548, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7087464..7166183, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene tRNA phosphotransferase 1 Neighboring gene fermitin family member 3 Neighboring gene predicted gene, 54052 Neighboring gene stress-induced phosphoprotein 1 Neighboring gene mono-ADP ribosylhydrolase 1 Neighboring gene RIKEN cDNA 5730409K12 gene Neighboring gene predicted gene, 38621 Neighboring gene OTU domain, ubiquitin aldehyde binding 1 Neighboring gene cytochrome c oxidase subunit 8A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FLRT3 Marks Direction-Selective Retinal Ganglion Cells That Project to the Medial Terminal Nucleus. Ruff T, et al. Front Mol Neurosci, 2021. PMID 34955746, Free PMC Article
  2. Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor signalling. Wheldon LM, et al. PLoS One, 2010 Apr 22. PMID 20421966, Free PMC Article
  3. Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons. Del Toro D, et al. Cell, 2020 Jan 23. PMID 31928845, Free PMC Article
  4. Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Haines BP, et al. Dev Biol, 2006 Sep 1. PMID 16872596
  5. Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules. Del Toro D, et al. Cell, 2017 May 4. PMID 28475893

See all (25) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice with deletions of FLRT1 and FLRT3 adhesion molecules develop macroscopic sulci with preserved layered organization and radial glial morphology. Cortex folding in these mutants does not require progenitor cell amplification but is dependent on changes in neuron migration.
    Title: Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules.
  2. FLRT1 is expressed at brain compartmental boundaries in embryo
    Title: Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat transmembrane protein FLRT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201411.2 → NP_958813.1  leucine-rich repeat transmembrane protein FLRT1

    See identical proteins and their annotated locations for NP_958813.1

    Status: VALIDATED

    Source sequence(s)
    AC109619, AK031503, BE947674
    Consensus CDS
    CCDS29519.1
    UniProtKB/Swiss-Prot
    Q6RKD8
    UniProtKB/TrEMBL
    A0A452J8F8
    Related
    ENSMUSP00000109010.3, ENSMUST00000113383.4
    Conserved Domains (4) summary
    PRK15370
    Location:58 → 329
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:300 → 406
    PCC; polycystin cation channel protein
    smart00060
    Location:441 → 505
    FN3; Fibronectin type 3 domain
    sd00033
    Location:108 → 128
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    7064829..7143548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527170.4 → XP_006527233.1  leucine-rich repeat transmembrane protein FLRT1 isoform X1

    See identical proteins and their annotated locations for XP_006527233.1

    UniProtKB/Swiss-Prot
    Q6RKD8
    UniProtKB/TrEMBL
    A0A452J8F8
    Conserved Domains (4) summary
    PRK15370
    Location:58 → 329
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:300 → 406
    PCC; polycystin cation channel protein
    smart00060
    Location:441 → 505
    FN3; Fibronectin type 3 domain
    sd00033
    Location:108 → 128
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_006527169.3 → XP_006527232.1  leucine-rich repeat transmembrane protein FLRT1 isoform X1

    See identical proteins and their annotated locations for XP_006527232.1

    UniProtKB/Swiss-Prot
    Q6RKD8
    UniProtKB/TrEMBL
    A0A452J8F8
    Conserved Domains (4) summary
    PRK15370
    Location:58 → 329
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:300 → 406
    PCC; polycystin cation channel protein
    smart00060
    Location:441 → 505
    FN3; Fibronectin type 3 domain
    sd00033
    Location:108 → 128
    LRR_RI; leucine-rich repeat [structural motif]

  3. XM_006527171.5 → XP_006527234.1  leucine-rich repeat transmembrane protein FLRT1 isoform X1

    See identical proteins and their annotated locations for XP_006527234.1

    UniProtKB/Swiss-Prot
    Q6RKD8
    UniProtKB/TrEMBL
    A0A452J8F8
    Conserved Domains (4) summary
    PRK15370
    Location:58 → 329
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:300 → 406
    PCC; polycystin cation channel protein
    smart00060
    Location:441 → 505
    FN3; Fibronectin type 3 domain
    sd00033
    Location:108 → 128
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RKD8.2 GenPept UniProtKB/Swiss-Prot:Q6RKD8

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