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Arhgef9 CDC42 guanine nucleotide exchange factor 9 [ Mus musculus (house mouse) ]

Gene ID: 236915, updated on 3-Apr-2024

Summary

Official Symbol
Arhgef9provided by MGI
Official Full Name
CDC42 guanine nucleotide exchange factor 9provided by MGI
Primary source
MGI:MGI:2442233
See related
Ensembl:ENSMUSG00000025656 AllianceGenome:MGI:2442233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630036L12Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in regulation of postsynaptic specialization assembly. Located in GABA-ergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; dorsal root ganglion; and ear. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 8. Orthologous to human ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 27.9), cortex adult (RPKM 25.1) and 8 other tissues See more
Orthologs
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Genomic context

See Arhgef9 in Genome Data Viewer
Location:
X C3; X 41.85 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (94092536..94240801, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (95048930..95196853, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47564 Neighboring gene germ cell-less homolog 1 pseudogene Neighboring gene spindlin family, member 4 Neighboring gene STARR-seq mESC enhancer starr_47565 Neighboring gene STARR-seq mESC enhancer starr_47566 Neighboring gene adenylate kinase 1 pseudogene Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glycinergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic specialization ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 9
Names
CDC42 guanine nucleotide exchange factor (GEF) 9
collybistin
rac/Cdc42 guanine nucleotide exchange factor 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033329.4NP_001028501.1  rho guanine nucleotide exchange factor 9 isoform a

    See identical proteins and their annotated locations for NP_001028501.1

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
    Consensus CDS
    CCDS53137.1
    UniProtKB/Swiss-Prot
    B1AXI3, B1AXI5, B9EJ88, Q3TQ60, Q3UTH8, Q80U06, Q8CAF9
    UniProtKB/TrEMBL
    B1AXI4
    Related
    ENSMUSP00000109510.2, ENSMUST00000113878.8
    Conserved Domains (3) summary
    cd11975
    Location:768
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:107286
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:291430
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  2. NM_001290384.2NP_001277313.1  rho guanine nucleotide exchange factor 9 isoform b

    See identical proteins and their annotated locations for NP_001277313.1

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
    Consensus CDS
    CCDS72409.1
    UniProtKB/TrEMBL
    B1AXI4
    Related
    ENSMUSP00000138668.2, ENSMUST00000182001.8
    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily
  3. NM_001290385.2NP_001277314.1  rho guanine nucleotide exchange factor 9 isoform b

    See identical proteins and their annotated locations for NP_001277314.1

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
    Consensus CDS
    CCDS72409.1
    UniProtKB/TrEMBL
    B1AXI4
    Related
    ENSMUSP00000109508.2, ENSMUST00000113876.9
    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily
  4. NM_001405901.1NP_001392830.1  rho guanine nucleotide exchange factor 9 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  5. NM_001405902.1NP_001392831.1  rho guanine nucleotide exchange factor 9 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
    Related
    ENSMUSP00000109516.2, ENSMUST00000113884.8
  6. NM_001405903.1NP_001392832.1  rho guanine nucleotide exchange factor 9 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  7. NM_001405904.1NP_001392833.1  rho guanine nucleotide exchange factor 9 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  8. NM_001405905.1NP_001392834.1  rho guanine nucleotide exchange factor 9 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
    UniProtKB/Swiss-Prot
    B1AXI3, B1AXI5, B9EJ88, Q3TQ60, Q3UTH8, Q80U06, Q8CAF9
  9. NM_001405906.1NP_001392835.1  rho guanine nucleotide exchange factor 9 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
    Related
    ENSMUSP00000109515.2, ENSMUST00000113883.8
  10. NM_001405907.1NP_001392836.1  rho guanine nucleotide exchange factor 9 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  11. NM_001405908.1NP_001392837.1  rho guanine nucleotide exchange factor 9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  12. NM_001405909.1NP_001392838.1  rho guanine nucleotide exchange factor 9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  13. NM_001405910.1NP_001392839.1  rho guanine nucleotide exchange factor 9 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  14. NM_001405911.1NP_001392840.1  rho guanine nucleotide exchange factor 9 isoform j

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  15. NM_001405912.1NP_001392841.1  rho guanine nucleotide exchange factor 9 isoform k

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  16. NM_001405913.1NP_001392842.1  rho guanine nucleotide exchange factor 9 isoform l

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  17. NM_001405914.1NP_001392843.1  rho guanine nucleotide exchange factor 9 isoform l

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  18. NM_001405915.1NP_001392844.1  rho guanine nucleotide exchange factor 9 isoform m

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
    Related
    ENSMUSP00000109505.2, ENSMUST00000113873.9
  19. NM_001405916.1NP_001392845.1  rho guanine nucleotide exchange factor 9 isoform n

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  20. NM_001405917.1NP_001392846.1  rho guanine nucleotide exchange factor 9 isoform n

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092
  21. NM_001405918.1NP_001392847.1  rho guanine nucleotide exchange factor 9 isoform n

    Status: VALIDATED

    Source sequence(s)
    AL807821, BX470092

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    94092536..94240801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251325.2XP_030107185.1  rho guanine nucleotide exchange factor 9 isoform X9

    UniProtKB/TrEMBL
    A0A0G2JE35
    Related
    ENSMUSP00000138258.2, ENSMUST00000128565.8
    Conserved Domains (3) summary
    cd11975
    Location:1475
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:114293
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:298437
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  2. XM_036161929.1XP_036017822.1  rho guanine nucleotide exchange factor 9 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JE35
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  3. XM_011247585.3XP_011245887.1  rho guanine nucleotide exchange factor 9 isoform X8

    UniProtKB/TrEMBL
    S4R1K5
    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily