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ARHGEF9 Cdc42 guanine nucleotide exchange factor 9 [ Homo sapiens (human) ]

Gene ID: 23229, updated on 9-Dec-2018

Summary

Official Symbol
ARHGEF9provided by HGNC
Official Full Name
Cdc42 guanine nucleotide exchange factor 9provided by HGNC
Primary source
HGNC:HGNC:14561
See related
Ensembl:ENSG00000131089 MIM:300429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN
Summary
The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in brain (RPKM 18.5), heart (RPKM 6.1) and 21 other tissues See more
Orthologs

Genomic context

See ARHGEF9 in Genome Data Viewer
Location:
Xq11.1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (63634967..63785546, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (62854847..63005426, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene spindlin family member 4 Neighboring gene long intergenic non-protein coding RNA 1278 Neighboring gene ARHGEF9 intronic transcript 1 Neighboring gene basic transcription factor 3 pseudogene 8 Neighboring gene microRNA 1468 Neighboring gene heterogeneous nuclear ribonucleoprotein D pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Early infantile epileptic encephalopathy 8
MedGen: C1845102 OMIM: 300607 GeneReviews: Hyperekplexia
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-10-12)

ClinGen Genome Curation Page
Haploinsufficency

Some evidence for dosage pathogenicity (Last evaluated (2012-10-12)

ClinGen Genome Curation PagePubMed

Pathways from BioSystems

  • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
    Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
  • Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
  • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
  • GABA A receptor activation, organism-specific biosystem (from REACTOME)
    GABA A receptor activation, organism-specific biosystemGABA B receptors are G protein coupled receptors that are activated by GABA binding to the B1 subunit and B2 subunit alters the activity of adenylate cyclase by interacting with the G alpha i/alpha 0...
  • GABA receptor activation, organism-specific biosystem (from REACTOME)
    GABA receptor activation, organism-specific biosystemGamma aminobutyric acid (GABA) receptors are the major inhibitory receptors in human synapses. They are of two types. GABA A receptors are fast-acting ligand gated chloride ion channels that mediate ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Ligand-gated ion channel transport, organism-specific biosystem (from REACTOME)
    Ligand-gated ion channel transport, organism-specific biosystemLigand-gated ion channels (LGICs) are a group of transmembrane ion channels that are opened or closed in response to the binding of a chemical messenger (Purves, 2001).
  • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
    NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
  • Regulation of CDC42 activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of CDC42 activity, organism-specific biosystem
    Regulation of CDC42 activity
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
  • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
    p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0424

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic specialization assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 9
Names
Cdc42 guanine nucleotide exchange factor (GEF) 9
PEM-2 homolog
hPEM-2 collybistin
rac/Cdc42 guanine nucleotide exchange factor 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016975.1 RefSeqGene

    Range
    35396..155579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173479.1NP_001166950.1  rho guanine nucleotide exchange factor 9 isoform 2

    See identical proteins and their annotated locations for NP_001166950.1

    Status: REVIEWED

    Source sequence(s)
    AB007884, AK295033, DB227223
    Consensus CDS
    CCDS55430.1
    UniProtKB/Swiss-Prot
    O43307
    Related
    ENSP00000485369.1, ENST00000623517.3
    Conserved Domains (2) summary
    smart00325
    Location:54233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:238377
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  2. NM_001173480.1NP_001166951.1  rho guanine nucleotide exchange factor 9 isoform 3

    See identical proteins and their annotated locations for NP_001166951.1

    Status: REVIEWED

    Source sequence(s)
    AB007884, BC056892, BP270451
    Consensus CDS
    CCDS55429.1
    UniProtKB/Swiss-Prot
    O43307
    Related
    ENSP00000485626.1, ENST00000624843.3
    Conserved Domains (2) summary
    smart00325
    Location:5184
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:189328
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  3. NM_001330495.1NP_001317424.1  rho guanine nucleotide exchange factor 9 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL355142, AL391277, AL451106
    Consensus CDS
    CCDS83477.1
    UniProtKB/TrEMBL
    B1AMR3
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  4. NM_001353921.1NP_001340850.1  rho guanine nucleotide exchange factor 9 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000399994.3, ENST00000437457.6
    Conserved Domains (3) summary
    cd11975
    Location:1475
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:114293
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:298437
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  5. NM_001353922.1NP_001340851.1  rho guanine nucleotide exchange factor 9 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    cd11975
    Location:1475
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:114293
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:298393
    PH-like; Pleckstrin homology-like domain
  6. NM_001353923.1NP_001340852.1  rho guanine nucleotide exchange factor 9 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Consensus CDS
    CCDS87753.1
    Related
    ENSP00000490940.1, ENST00000635729.1
    Conserved Domains (3) summary
    cd11975
    Location:2081
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:120299
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:304443
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  7. NM_001353924.1NP_001340853.1  rho guanine nucleotide exchange factor 9 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) encodes a protein that is the same length as variant (9) but isoforms 8 and 9 have distinct N-termini.
    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000490459.1, ENST00000637040.1
    Conserved Domains (2) summary
    smart00325
    Location:47226
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:231370
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  8. NM_001353926.1NP_001340855.1  rho guanine nucleotide exchange factor 9 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) encodes a protein that is the same length as variant (8) but isoforms 8 and 9 have distinct N-termini.
    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (2) summary
    smart00325
    Location:47226
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:231370
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  9. NM_001353927.1NP_001340856.1  rho guanine nucleotide exchange factor 9 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:270365
    PH-like; Pleckstrin homology-like domain
  10. NM_001353928.1NP_001340857.1  rho guanine nucleotide exchange factor 9 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    cd11975
    Location:768
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:107286
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:291386
    PH-like; Pleckstrin homology-like domain
  11. NM_015185.2NP_056000.1  rho guanine nucleotide exchange factor 9 isoform 1

    See identical proteins and their annotated locations for NP_056000.1

    Status: REVIEWED

    Source sequence(s)
    AB007884, BP270451
    Consensus CDS
    CCDS35315.1
    UniProtKB/Swiss-Prot
    O43307
    Related
    ENSP00000253401.6, ENST00000253401.10
    Conserved Domains (3) summary
    cd11975
    Location:768
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:107286
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:291430
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    63634967..63785546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452358.1XP_024308126.1  rho guanine nucleotide exchange factor 9 isoform X12

    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:270343
    PH-like; Pleckstrin homology-like domain
  2. XM_017029373.2XP_016884862.1  rho guanine nucleotide exchange factor 9 isoform X8

    UniProtKB/Swiss-Prot
    O43307
    Conserved Domains (2) summary
    smart00325
    Location:5184
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:189328
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  3. XM_017029374.2XP_016884863.1  rho guanine nucleotide exchange factor 9 isoform X9

  4. XM_017029380.2XP_016884869.1  rho guanine nucleotide exchange factor 9 isoform X13

    Related
    ENSP00000489670.1, ENST00000637855.1
  5. XM_017029367.1XP_016884856.1  rho guanine nucleotide exchange factor 9 isoform X5

    UniProtKB/TrEMBL
    B1AMR3
    Related
    ENSP00000490269.1, ENST00000637417.1
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  6. XM_017029364.1XP_016884853.1  rho guanine nucleotide exchange factor 9 isoform X1

  7. XM_011530890.1XP_011529192.1  rho guanine nucleotide exchange factor 9 isoform X3

    See identical proteins and their annotated locations for XP_011529192.1

    Conserved Domains (3) summary
    cd11975
    Location:768
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:107286
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:291430
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  8. XM_011530892.1XP_011529194.1  rho guanine nucleotide exchange factor 9 isoform X6

    See identical proteins and their annotated locations for XP_011529194.1

    Related
    ENSP00000489637.1, ENST00000637723.1
    Conserved Domains (2) summary
    smart00325
    Location:47226
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:231370
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  9. XM_017029366.1XP_016884855.1  rho guanine nucleotide exchange factor 9 isoform X2

    UniProtKB/Swiss-Prot
    O43307
    Related
    ENSP00000490667.1, ENST00000636926.1
    Conserved Domains (3) summary
    cd11975
    Location:768
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:107286
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:291430
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  10. XM_017029372.1XP_016884861.1  rho guanine nucleotide exchange factor 9 isoform X7

    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:270365
    PH-like; Pleckstrin homology-like domain
  11. XM_017029379.1XP_016884868.1  rho guanine nucleotide exchange factor 9 isoform X12

    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:270343
    PH-like; Pleckstrin homology-like domain
  12. XM_005262251.1XP_005262308.1  rho guanine nucleotide exchange factor 9 isoform X5

    See identical proteins and their annotated locations for XP_005262308.1

    UniProtKB/TrEMBL
    B1AMR3
    Related
    ENSP00000485144.1, ENST00000624210.3
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  13. XM_017029368.2XP_016884857.1  rho guanine nucleotide exchange factor 9 isoform X5

    UniProtKB/TrEMBL
    B1AMR3
    Related
    ENSP00000490679.1, ENST00000637557.1
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  14. XM_024452356.1XP_024308124.1  rho guanine nucleotide exchange factor 9 isoform X4

    Conserved Domains (3) summary
    cd11975
    Location:566
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:105284
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:289428
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  15. XM_005262250.4XP_005262307.1  rho guanine nucleotide exchange factor 9 isoform X5

    See identical proteins and their annotated locations for XP_005262307.1

    UniProtKB/TrEMBL
    B1AMR3
    Related
    ENSP00000490063.1, ENST00000636048.1
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  16. XM_017029377.2XP_016884866.1  rho guanine nucleotide exchange factor 9 isoform X10

  17. XM_024452357.1XP_024308125.1  rho guanine nucleotide exchange factor 9 isoform X5

    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  18. XM_017029378.2XP_016884867.1  rho guanine nucleotide exchange factor 9 isoform X11

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