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ARHGEF9 Cdc42 guanine nucleotide exchange factor 9 [ Homo sapiens (human) ]

Gene ID: 23229, updated on 6-May-2021

Summary

Official Symbol
ARHGEF9provided by HGNC
Official Full Name
Cdc42 guanine nucleotide exchange factor 9provided by HGNC
Primary source
HGNC:HGNC:14561
See related
Ensembl:ENSG00000131089 MIM:300429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEE8; PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN
Summary
The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in brain (RPKM 18.5), heart (RPKM 6.1) and 21 other tissues See more
Orthologs
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Genomic context

See ARHGEF9 in Genome Data Viewer
Location:
Xq11.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (63634967..63785546, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (62854847..63005094, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SPIN4 antisense RNA 1 Neighboring gene spindlin family member 4 Neighboring gene long intergenic non-protein coding RNA 1278 Neighboring gene ARHGEF9 intronic transcript 1 Neighboring gene basic transcription factor 3 pseudogene 8 Neighboring gene microRNA 1468 Neighboring gene heterogeneous nuclear ribonucleoprotein D pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Early infantile epileptic encephalopathy 8 Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2012-10-12)

ClinGen Genome Curation Page
Haploinsufficency

Some evidence for dosage pathogenicity (Last evaluated 2012-10-12)

ClinGen Genome Curation PagePubMed

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0424

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 9
Names
Cdc42 guanine nucleotide exchange factor (GEF) 9
PEM-2 homolog
hPEM-2 collybistin
rac/Cdc42 guanine nucleotide exchange factor 9

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016975.1 RefSeqGene

    Range
    35424..155580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173479.2NP_001166950.1  rho guanine nucleotide exchange factor 9 isoform 2

    See identical proteins and their annotated locations for NP_001166950.1

    Status: REVIEWED

    Source sequence(s)
    AB007884, AK295033, AL391277
    Consensus CDS
    CCDS55430.1
    UniProtKB/Swiss-Prot
    O43307
    Related
    ENSP00000485369.1, ENST00000623517.3
    Conserved Domains (2) summary
    smart00325
    Location:54233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:238377
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  2. NM_001173480.2NP_001166951.1  rho guanine nucleotide exchange factor 9 isoform 3

    See identical proteins and their annotated locations for NP_001166951.1

    Status: REVIEWED

    Source sequence(s)
    AB007884, AL391277, BC056892, BP270451
    Consensus CDS
    CCDS55429.1
    UniProtKB/Swiss-Prot
    O43307
    Related
    ENSP00000485626.1, ENST00000624843.3
    Conserved Domains (2) summary
    smart00325
    Location:5184
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:189328
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  3. NM_001330495.2NP_001317424.1  rho guanine nucleotide exchange factor 9 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL355142, AL391277, AL451106
    Consensus CDS
    CCDS83477.1
    UniProtKB/TrEMBL
    B1AMR3
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  4. NM_001353921.2NP_001340850.1  rho guanine nucleotide exchange factor 9 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000500715.1, ENST00000671741.2
    Conserved Domains (3) summary
    cd11975
    Location:1475
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:114293
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:298437
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  5. NM_001353922.2NP_001340851.1  rho guanine nucleotide exchange factor 9 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    cd11975
    Location:1475
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:114293
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:298393
    PH-like; Pleckstrin homology-like domain
  6. NM_001353923.1NP_001340852.1  rho guanine nucleotide exchange factor 9 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Consensus CDS
    CCDS87753.1
    Related
    ENSP00000490940.1, ENST00000635729.1
    Conserved Domains (3) summary
    cd11975
    Location:2081
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:120299
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:304443
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  7. NM_001353924.2NP_001340853.1  rho guanine nucleotide exchange factor 9 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) encodes a protein that is the same length as variant (9) but isoforms 8 and 9 have distinct N-termini.
    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000490459.1, ENST00000637040.1
    Conserved Domains (2) summary
    smart00325
    Location:47226
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:231370
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  8. NM_001353926.2NP_001340855.1  rho guanine nucleotide exchange factor 9 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) encodes a protein that is the same length as variant (8) but isoforms 8 and 9 have distinct N-termini.
    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (2) summary
    smart00325
    Location:47226
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:231370
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  9. NM_001353927.2NP_001340856.1  rho guanine nucleotide exchange factor 9 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000500825.1, ENST00000672513.1
    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:270365
    PH-like; Pleckstrin homology-like domain
  10. NM_001353928.2NP_001340857.1  rho guanine nucleotide exchange factor 9 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    cd11975
    Location:768
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:107286
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:291386
    PH-like; Pleckstrin homology-like domain
  11. NM_001369030.1NP_001355959.1  rho guanine nucleotide exchange factor 9 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000500829.1, ENST00000671907.1
    Conserved Domains (3) summary
    cd11975
    Location:768
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:107286
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:291430
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  12. NM_001369031.1NP_001355960.1  rho guanine nucleotide exchange factor 9 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    cd11975
    Location:768
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:107286
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:291430
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  13. NM_001369032.1NP_001355961.1  rho guanine nucleotide exchange factor 9 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    cd11975
    Location:768
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:107286
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:291430
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  14. NM_001369033.1NP_001355962.1  rho guanine nucleotide exchange factor 9 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000485282.2, ENST00000624538.2
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  15. NM_001369034.1NP_001355963.1  rho guanine nucleotide exchange factor 9 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000490269.1, ENST00000637417.1
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  16. NM_001369035.1NP_001355964.1  rho guanine nucleotide exchange factor 9 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000485144.1, ENST00000624210.3
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  17. NM_001369036.1NP_001355965.1  rho guanine nucleotide exchange factor 9 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000490679.1, ENST00000637557.1
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  18. NM_001369037.1NP_001355966.1  rho guanine nucleotide exchange factor 9 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL391277, AL451106, BC018106
    Related
    ENSP00000364006.1, ENST00000374872.4
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  19. NM_001369038.1NP_001355967.1  rho guanine nucleotide exchange factor 9 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  20. NM_001369039.1NP_001355968.1  rho guanine nucleotide exchange factor 9 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (2) summary
    smart00325
    Location:47226
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:231370
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  21. NM_001369040.1NP_001355969.1  rho guanine nucleotide exchange factor 9 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Related
    ENSP00000499905.1, ENST00000672194.1
    Conserved Domains (2) summary
    smart00325
    Location:47226
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:231370
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  22. NM_001369041.1NP_001355970.1  rho guanine nucleotide exchange factor 9 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:270365
    PH-like; Pleckstrin homology-like domain
  23. NM_001369042.1NP_001355971.1  rho guanine nucleotide exchange factor 9 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (2) summary
    smart00325
    Location:5184
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:189328
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  24. NM_001369043.1NP_001355972.1  rho guanine nucleotide exchange factor 9 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:270343
    PH-like; Pleckstrin homology-like domain
  25. NM_001369044.1NP_001355973.1  rho guanine nucleotide exchange factor 9 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL355142, AL391277, AL451106
    Conserved Domains (3) summary
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17036
    Location:147
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:270343
    PH-like; Pleckstrin homology-like domain
  26. NM_001369045.1NP_001355974.1  rho guanine nucleotide exchange factor 9 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL391277, AL451106, BC043497
    Conserved Domains (2) summary
    smart00325
    Location:1148
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:153248
    PH-like; Pleckstrin homology-like domain
  27. NM_015185.3NP_056000.1  rho guanine nucleotide exchange factor 9 isoform 1

    See identical proteins and their annotated locations for NP_056000.1

    Status: REVIEWED

    Source sequence(s)
    AB007884, AL391277, BP270451
    Consensus CDS
    CCDS35315.1
    UniProtKB/Swiss-Prot
    O43307
    Related
    ENSP00000253401.6, ENST00000253401.10
    Conserved Domains (3) summary
    cd11975
    Location:768
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:107286
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:291430
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    63634967..63785546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029374.2XP_016884863.1  rho guanine nucleotide exchange factor 9 isoform X9

  2. XM_017029380.2XP_016884869.1  rho guanine nucleotide exchange factor 9 isoform X13

    Related
    ENSP00000489670.1, ENST00000637855.1
  3. XM_017029364.1XP_016884853.1  rho guanine nucleotide exchange factor 9 isoform X1

  4. XM_024452356.1XP_024308124.1  rho guanine nucleotide exchange factor 9 isoform X4

    Conserved Domains (3) summary
    cd11975
    Location:566
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:105284
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:289428
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  5. XM_017029377.2XP_016884866.1  rho guanine nucleotide exchange factor 9 isoform X10

  6. XM_024452357.1XP_024308125.1  rho guanine nucleotide exchange factor 9 isoform X5

    Conserved Domains (3) summary
    cd11975
    Location:147
    SH3_ARHGEF9; Src homology 3 domain of the Rho guanine nucleotide exchange factor ARHGEF9
    smart00325
    Location:86265
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:270409
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
  7. XM_017029378.2XP_016884867.1  rho guanine nucleotide exchange factor 9 isoform X11

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