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CHST5 carbohydrate sulfotransferase 5 [ Homo sapiens (human) ]

Gene ID: 23563, updated on 1-Aug-2020

Summary

Official Symbol
CHST5provided by HGNC
Official Full Name
carbohydrate sulfotransferase 5provided by HGNC
Primary source
HGNC:HGNC:1973
See related
Ensembl:ENSG00000135702 MIM:604817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
gn6st-3; hIGn6ST; I-GlcNAc6ST; glcNAc6ST-3; I-GlcNAc-6-ST
Summary
The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]
Expression
Biased expression in colon (RPKM 16.2), duodenum (RPKM 16.2) and 2 other tissues See more
Orthologs

Genomic context

See CHST5 in Genome Data Viewer
Location:
16q23.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (75528530..75536108, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (75562428..75570180, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 6 Neighboring gene TMEM231 pseudogene 1 Neighboring gene transmembrane protein 231 Neighboring gene GABA type A receptor associated protein like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • MGC74625

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylglucosamine 6-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
sulfotransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
keratan sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
protein sulfation TAS
Traceable Author Statement
more info
PubMed 
sulfur compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
intrinsic component of Golgi membrane NAS
Non-traceable Author Statement
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carbohydrate sulfotransferase 5
Names
GST4-alpha
N-acetylglucosamine 6-O-sulfotransferase 3
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha
intestinal GlcNAc-6-sulfotransferase
NP_078809.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029853.1 RefSeqGene

    Range
    5001..11641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024533.5NP_078809.2  carbohydrate sulfotransferase 5

    See identical proteins and their annotated locations for NP_078809.2

    Status: REVIEWED

    Source sequence(s)
    AC009163
    Consensus CDS
    CCDS10919.1
    UniProtKB/Swiss-Prot
    Q9GZS9
    Related
    ENSP00000338783.3, ENST00000336257.7
    Conserved Domains (1) summary
    pfam13469
    Location:65319
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    75528530..75536108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012126.1: Suppressed sequence

    Description
    NM_012126.1: This RefSeq was permanently suppressed because it was based on a rare read-through transcript that has insufficient support.
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