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Atrip ATR interacting protein [ Mus musculus (house mouse) ]

Gene ID: 235610, updated on 9-Mar-2023

Summary

Official Symbol
Atripprovided by MGI
Official Full Name
ATR interacting proteinprovided by MGI
Primary source
MGI:MGI:1925349
See related
Ensembl:ENSMUSG00000025646 AllianceGenome:MGI:1925349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6620401K05Rik
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Used to study Seckel syndrome. Orthologous to human ATRIP (ATR interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 11.5), thymus adult (RPKM 7.8) and 28 other tissues See more
Orthologs
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Genomic context

See Atrip in Genome Data Viewer
Location:
9; 9 F2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108888815..108903192, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109059747..109074124, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene shisa family member 5 Neighboring gene predicted gene, 53191 Neighboring gene three prime repair exonuclease 1 Neighboring gene translational machinery associated 7 Neighboring gene coiled-coil domain containing 51

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough Gm53191

Readthrough gene: Gm53191, Included gene: Trex1

Homology

Clone Names

  • MGC90531

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleobase-containing compound metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of ATR-ATRIP complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of ATR-ATRIP complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ATR-interacting protein
Names
ATM and Rad3 related interacting protein
NP_766362.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172774.3NP_766362.2  ATR-interacting protein

    See identical proteins and their annotated locations for NP_766362.2

    Status: VALIDATED

    Source sequence(s)
    AC140383, AK031257, BB649616
    Consensus CDS
    CCDS23545.1
    UniProtKB/Swiss-Prot
    E9QLS8, Q8BMG1
    Related
    ENSMUSP00000044831.3, ENSMUST00000045011.9
    Conserved Domains (1) summary
    cl09111
    Location:117205
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108888815..108903192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)