Format

Send to:

Choose Destination

Trex1 three prime repair exonuclease 1 [ Mus musculus (house mouse) ]

Gene ID: 22040, updated on 14-Mar-2017
Official Symbol
Trex1provided by MGI
Official Full Name
three prime repair exonuclease 1provided by MGI
Primary source
MGI:MGI:1328317
See related
Ensembl:ENSMUSG00000049734 Vega:OTTMUSG00000055468
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AU041952
Orthologs
Location:
9; 9 F2
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (109057932..109059723, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108960446..108962237, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene shisa family member 5 Neighboring gene ATR interacting protein Neighboring gene translational machinery associated 7

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
    Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
  • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
    Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
3'-5'-exodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
MutLalpha complex binding ISA
Inferred from Sequence Alignment
more info
PubMed 
MutSalpha complex binding ISA
Inferred from Sequence Alignment
more info
PubMed 
adenyl deoxyribonucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
exodeoxyribonuclease III activity IEA
Inferred from Electronic Annotation
more info
 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
three-prime repair exonuclease 1
Names
3'-5' exonuclease TREX1
DNase III
three prime exonuclease 1
trophoblast expressed 1
NP_001012236.1
NP_035767.4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012236.1NP_001012236.1  three-prime repair exonuclease 1

    See identical proteins and their annotated locations for NP_001012236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK087832, AU041952
    Consensus CDS
    CCDS23544.1
    UniProtKB/Swiss-Prot
    Q91XB0
    Related
    ENSMUSP00000107684, OTTMUSP00000022433, ENSMUST00000112053, OTTMUST00000048744
    Conserved Domains (2) summary
    cd06136
    Location:14211
    TREX1_2; DEDDh 3'-5' exonuclease domain of three prime repair exonuclease (TREX)1, TREX2, and similar proteins
    COG0847
    Location:13204
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
  2. NM_011637.6NP_035767.4  three-prime repair exonuclease 1

    See identical proteins and their annotated locations for NP_035767.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AU041952, BY234700, CA323364, CO041929
    Consensus CDS
    CCDS23544.1
    UniProtKB/Swiss-Prot
    Q91XB0
    Related
    ENSMUSP00000050971, OTTMUSP00000022432, ENSMUST00000061973, OTTMUST00000048743
    Conserved Domains (2) summary
    cd06136
    Location:14211
    TREX1_2; DEDDh 3'-5' exonuclease domain of three prime repair exonuclease (TREX)1, TREX2, and similar proteins
    COG0847
    Location:13204
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    109057932..109059723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center