Format

Send to:

Choose Destination

ATRIP ATR interacting protein [ Homo sapiens (human) ]

Gene ID: 84126, updated on 28-Aug-2021

Summary

Official Symbol
ATRIPprovided by HGNC
Official Full Name
ATR interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:33499
See related
Ensembl:ENSG00000164053 MIM:606605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Annotation information
Note: GeneID 11277 was annotated as a single gene with two non-overlapping coding regions. GeneID 11277 now represents only the downstream coding region encoding three prime repair exonuclease 1. The upstream coding region is represented by geneID 84126. [29 May 2007]
Expression
Broad expression in testis (RPKM 11.6), thyroid (RPKM 3.8) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ATRIP in Genome Data Viewer
Location:
3p21.31
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (48446737..48467645)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48488141..48509044)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene plexin B1 Neighboring gene uncharacterized LOC105377077 Neighboring gene coiled-coil domain containing 51 Neighboring gene ATRIP-TREX1 readthrough Neighboring gene translation machinery associated 7 homolog Neighboring gene three prime repair exonuclease 1 Neighboring gene shisa family member 5 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene microRNA 6823

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.
GeneReviews: Not available
Joint influence of small-effect genetic variants on human longevity.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ATRIP-TREX1

Readthrough gene: ATRIP-TREX1, Included gene: TREX1

Homology

Clone Names

  • FLJ12343, MGC20625, MGC21482, MGC26740, DKFZp762J2115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA damage checkpoint signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ATR-interacting protein
Names
ATM and Rad3-related-interacting protein
NP_001257951.1
NP_001257952.1
NP_115542.2
NP_569055.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041782.1 RefSeqGene

    Range
    5001..23946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001271022.2NP_001257951.1  ATR-interacting protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, contains an alternate internal exon, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC134772, AK300548, BC030597
    Consensus CDS
    CCDS59450.1
    UniProtKB/Swiss-Prot
    Q8WXE1
    Related
    ENSP00000489041.2, ENST00000634384.2
    Conserved Domains (1) summary
    pfam16515
    Location:786
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
  2. NM_001271023.2NP_001257952.1  ATR-interacting protein isoform 4

    See identical proteins and their annotated locations for NP_001257952.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC134772, BC030597
    Consensus CDS
    CCDS59449.1
    UniProtKB/Swiss-Prot
    Q8WXE1
    Related
    ENSP00000400930.1, ENST00000412052.4
    Conserved Domains (1) summary
    cl09111
    Location:20114
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  3. NM_032166.4NP_115542.2  ATR-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_115542.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC134772, BC014153, DC402185
    Consensus CDS
    CCDS2767.1
    UniProtKB/Swiss-Prot
    Q8WXE1
    UniProtKB/TrEMBL
    A0A024R307
    Related
    ENSP00000302338.5, ENST00000346691.9
    Conserved Domains (1) summary
    cl09111
    Location:113207
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  4. NM_130384.3NP_569055.1  ATR-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_569055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC134772, AF451323, BC030597, CB960784, DC402185
    Consensus CDS
    CCDS2768.1
    UniProtKB/Swiss-Prot
    Q8WXE1
    UniProtKB/TrEMBL
    A0A024R2U4
    Related
    ENSP00000323099.3, ENST00000320211.10
    Conserved Domains (1) summary
    pfam12718
    Location:113212
    Tropomyosin_1; Tropomyosin like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    48446737..48467645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center