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FPGS folylpolyglutamate synthase [ Homo sapiens (human) ]

Gene ID: 2356, updated on 22-Aug-2021

Summary

Official Symbol
FPGSprovided by HGNC
Official Full Name
folylpolyglutamate synthaseprovided by HGNC
Primary source
HGNC:HGNC:3824
See related
Ensembl:ENSG00000136877 MIM:136510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in ovary (RPKM 14.6), fat (RPKM 12.1) and 25 other tissues See more
Orthologs
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Genomic context

See FPGS in Genome Data Viewer
Location:
9q34.11
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (127802858..127814520)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130565137..130576360)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7866 Neighboring gene Sharpr-MPRA regulatory region 2041 Neighboring gene microRNA 3960 Neighboring gene microRNA 2861 Neighboring gene cyclin dependent kinase 9 Neighboring gene uncharacterized LOC102723566 Neighboring gene endoglin Neighboring gene uncharacterized LOC105379841

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of folylpolyglutamate synthase (FPGS) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables tetrahydrofolylpolyglutamate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tetrahydrofolylpolyglutamate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tetrahydrofolylpolyglutamate synthase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
folylpolyglutamate synthase, mitochondrial
Names
folylpoly-gamma-glutamate synthetase
tetrahydrofolate synthase
tetrahydrofolylpolyglutamate synthase
NP_001018088.1
NP_001275732.1
NP_004948.4
XP_005251921.1
XP_011516741.1
XP_016870054.1
XP_016870055.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023245.1 RefSeqGene

    Range
    5008..16207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001018078.2NP_001018088.1  folylpolyglutamate synthase, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001018088.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon for its 5' UTR and uses a downstream start codon, compared to variant 1. It encodes isoform b which is a cytosolic protein and has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK056920, CB854085, DA987755
    Consensus CDS
    CCDS35149.1
    UniProtKB/Swiss-Prot
    Q05932
    Related
    ENSP00000362322.3, ENST00000373225.7
    Conserved Domains (2) summary
    PLN02881
    Location:16531
    PLN02881; tetrahydrofolylpolyglutamate synthase
    pfam02875
    Location:310391
    Mur_ligase_C; Mur ligase family, glutamate ligase domain
  2. NM_001288803.1NP_001275732.1  folylpolyglutamate synthase, mitochondrial isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This variant has two alternative translational start codons in the same reading frame which encode either a longer, signal-containing mitochondrial protein (isoform c) or a shorter, signal-less cytosolic protein.
    Source sequence(s)
    AK295309, CB854085, DC365273
    Consensus CDS
    CCDS75905.1
    UniProtKB/Swiss-Prot
    Q05932
    Related
    ENSP00000377309.2, ENST00000393706.6
    Conserved Domains (2) summary
    PLN02881
    Location:42555
    PLN02881; tetrahydrofolylpolyglutamate synthase
    pfam02875
    Location:334415
    Mur_ligase_C; Mur ligase family, glutamate ligase domain
  3. NM_004957.6NP_004948.4  folylpolyglutamate synthase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_004948.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform (a). This variant has two alternative translational start codons in the same reading frame which encode either a longer, signal-containing mitochondrial protein or a shorter, signal-less cytosolic protein.
    Source sequence(s)
    BC007121, BC064393, CB854085, DC365273
    Consensus CDS
    CCDS35148.1
    UniProtKB/Swiss-Prot
    Q05932
    Related
    ENSP00000362344.2, ENST00000373247.7
    Conserved Domains (2) summary
    PLN02881
    Location:42581
    PLN02881; tetrahydrofolylpolyglutamate synthase
    pfam02875
    Location:360441
    Mur_ligase_C; Mur ligase family, glutamate ligase domain

RNA

  1. NR_110170.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC009901, BG328181, CB854085, DC365273
    Related
    ENST00000460181.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    127802858..127814520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251864.4XP_005251921.1  folylpolyglutamate synthase, mitochondrial isoform X1

    Conserved Domains (2) summary
    PLN02881
    Location:42441
    PLN02881; tetrahydrofolylpolyglutamate synthase
    pfam02875
    Location:360441
    Mur_ligase_C; Mur ligase family, glutamate ligase domain
  2. XM_017014566.1XP_016870055.1  folylpolyglutamate synthase, mitochondrial isoform X3

    Conserved Domains (2) summary
    PLN02881
    Location:3300
    PLN02881; tetrahydrofolylpolyglutamate synthase
    pfam02875
    Location:79160
    Mur_ligase_C; Mur ligase family, glutamate ligase domain
  3. XM_017014565.2XP_016870054.1  folylpolyglutamate synthase, mitochondrial isoform X2

  4. XM_011518439.2XP_011516741.1  folylpolyglutamate synthase, mitochondrial isoform X3

    Conserved Domains (2) summary
    PLN02881
    Location:3300
    PLN02881; tetrahydrofolylpolyglutamate synthase
    pfam02875
    Location:79160
    Mur_ligase_C; Mur ligase family, glutamate ligase domain

RNA

  1. XR_242582.4 RNA Sequence

  2. XR_242581.4 RNA Sequence

    Related
    ENST00000630236.2
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