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Fpgs folylpolyglutamyl synthetase [ Mus musculus (house mouse) ]

Gene ID: 14287, updated on 5-Jan-2023

Summary

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Official Symbol
Fpgsprovided by MGI
Official Full Name
folylpolyglutamyl synthetaseprovided by MGI
Primary source
MGI:MGI:95576
See related
Ensembl:ENSMUSG00000009566 AllianceGenome:MGI:95576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable tetrahydrofolylpolyglutamate synthase activity. Predicted to be involved in cell population proliferation; glutamate metabolic process; and tetrahydrofolylpolyglutamate biosynthetic process. Predicted to act upstream of or within one-carbon metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human FPGS (folylpolyglutamate synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 116.7), ovary adult (RPKM 47.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Fpgs in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32572621..32594208, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32682609..32704196, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endoglin Neighboring gene microRNA 1954 Neighboring gene predicted gene, 26236 Neighboring gene microRNA 8093 Neighboring gene cyclin-dependent kinase 9 (CDC2-related kinase) Neighboring gene microRNA 2861 Neighboring gene microRNA 3960

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Humanizing mouse folate metabolism: conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure. Yang C, et al. FASEB J, 2014 May. PMID 24532667, Free PMC Article
  2. Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity. Sakamoto E, et al. Biochem Biophys Res Commun, 2008 Jan 25. PMID 18035049
  3. A mouse gene that coordinates epigenetic controls and transcriptional interference to achieve tissue-specific expression. Racanelli AC, et al. Mol Cell Biol, 2008 Jan. PMID 17998333, Free PMC Article
  4. Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding. Sheng Y, et al. Arch Biochem Biophys, 2002 Jun 1. PMID 12051687
  5. Organization and alternate splicing of the murine folylpolyglutamate synthetase gene. Different splice variants in L1210 cells encode mitochondrial or cytosolic forms of the enzyme. Roy K, et al. J Biol Chem, 1996 Sep 27. PMID 8798611

See all (34) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that FPGS and GGH expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU.
    Title: Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity.
  2. Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
    Title: Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tetrahydrofolylpolyglutamate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables tetrahydrofolylpolyglutamate synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in folic acid-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in folic acid-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolylpolyglutamate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in tetrahydrofolylpolyglutamate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
folylpolyglutamate synthase, mitochondrial
Names
folylpoly-gamma-glutamate synthetase
tetrahydrofolate synthase
tetrahydrofolylpolyglutamate synthase
NP_034366.2
XP_006497759.2
XP_006497760.1
XP_006497761.4
XP_030103361.1
XP_030103362.1
XP_030103363.1
XP_036014218.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010236.2 → NP_034366.2  folylpolyglutamate synthase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_034366.2

    Status: VALIDATED

    Source sequence(s)
    BE627294, BM944126, BY025719, CA558410, CF749232
    Consensus CDS
    CCDS15926.1
    UniProtKB/Swiss-Prot
    P48760, Q99K38
    Related
    ENSMUSP00000028148.5, ENSMUST00000028148.11
    Conserved Domains (2) summary
    PLN02881
    Location:44 → 581
    PLN02881; tetrahydrofolylpolyglutamate synthase
    pfam02875
    Location:360 → 441
    Mur_ligase_C; Mur ligase family, glutamate ligase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32572621..32594208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247502.1 → XP_030103362.1  folylpolyglutamate synthase, mitochondrial isoform X6

    Conserved Domains (1) summary
    PLN02881
    Location:1 → 408
    PLN02881; tetrahydrofolylpolyglutamate synthase

  2. XM_030247501.1 → XP_030103361.1  folylpolyglutamate synthase, mitochondrial isoform X3

    Conserved Domains (1) summary
    PLN02881
    Location:39 → 577
    PLN02881; tetrahydrofolylpolyglutamate synthase

  3. XM_006497697.3 → XP_006497760.1  folylpolyglutamate synthase, mitochondrial isoform X2

    Conserved Domains (1) summary
    PLN02881
    Location:39 → 582
    PLN02881; tetrahydrofolylpolyglutamate synthase

  4. XM_006497698.4 → XP_006497761.4  folylpolyglutamate synthase, mitochondrial isoform X4

    Conserved Domains (1) summary
    PLN02881
    Location:44 → 454
    PLN02881; tetrahydrofolylpolyglutamate synthase

  5. XM_036158325.1 → XP_036014218.1  folylpolyglutamate synthase, mitochondrial isoform X5

    Conserved Domains (1) summary
    PLN02881
    Location:44 → 449
    PLN02881; tetrahydrofolylpolyglutamate synthase

  6. XM_006497696.5 → XP_006497759.2  folylpolyglutamate synthase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PLN02881
    Location:44 → 586
    PLN02881; tetrahydrofolylpolyglutamate synthase

  7. XM_030247503.2 → XP_030103363.1  folylpolyglutamate synthase, mitochondrial isoform X6

    Conserved Domains (1) summary
    PLN02881
    Location:1 → 408
    PLN02881; tetrahydrofolylpolyglutamate synthase

RNA

  1. XR_004938352.1 RNA Sequence

  2. XR_001780795.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48760.3 GenPept UniProtKB/Swiss-Prot:P48760

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