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Parp3 poly (ADP-ribose) polymerase family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 235587, updated on 9-May-2024

Summary

Official Symbol
Parp3provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 3provided by MGI
Primary source
MGI:MGI:1891258
See related
Ensembl:ENSMUSG00000023249 AllianceGenome:MGI:1891258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTD3; Adprt3; PARP-3; ADPRT-3; Adprtl3; pADPRT-3; A930002C11Rik
Summary
Predicted to enable NAD DNA ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; and protein ADP-ribosylase activity. Involved in negative regulation of isotype switching. Acts upstream of or within double-strand break repair. Located in site of double-strand break. Orthologous to human PARP3 (poly(ADP-ribose) polymerase family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 25.0), bladder adult (RPKM 19.6) and 18 other tissues See more
Orthologs
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Genomic context

See Parp3 in Genome Data Viewer
Location:
9 F1; 9 57.58 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106347521..106354148, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106470322..106476949, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 14A Neighboring gene abhydrolase domain containing 14b Neighboring gene poly(rC) binding protein 4 Neighboring gene G protein-coupled receptor 62 Neighboring gene STARR-positive B cell enhancer ABC_E716 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene STARR-seq mESC enhancer starr_25152 Neighboring gene IQ motif containing F1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD DNA ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+- protein-aspartate ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+- protein-lysine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein-glutamate ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within double-strand break repair IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of telomerase RNA reverse transcriptase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA ligation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
 
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
involved_in protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP3
Names
A DP-ribosyltransferase (NAD+; poly (ADP-ribose polymerase)-like 3
ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3
ADP-ribosyltransferase diphtheria toxin-like 3
DNA ADP-ribosyltransferase PARP3
NAD(+) ADP-ribosyltransferase 3
NAD+ ADP-ribosyltransferase 3
Poly[ADP-ribose] synthetase-3
poly [ADP-ribose] polymerase 3
poly[ADP-ribose] synthase 3
NP_001298079.1
NP_663594.2
XP_006511781.1
XP_006511782.1
XP_006511783.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311150.1NP_001298079.1  protein mono-ADP-ribosyltransferase PARP3 isoform 1

    See identical proteins and their annotated locations for NP_001298079.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF368233, AK044223, AK147868
    Consensus CDS
    CCDS81066.1
    UniProtKB/Swiss-Prot
    A0A1L1SRP6, E9PX17, E9Q992, Q3UGL7, Q3ULW8, Q8BHN6, Q8BXU2, Q8CFB8, Q91YR6
    Related
    ENSMUSP00000108098.3, ENSMUST00000112479.9
    Conserved Domains (2) summary
    cd01437
    Location:181532
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    cl01581
    Location:56154
    WGR; WGR domain
  2. NM_145619.3NP_663594.2  protein mono-ADP-ribosyltransferase PARP3 isoform 2

    See identical proteins and their annotated locations for NP_663594.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AF368233, AK147868
    Consensus CDS
    CCDS23480.1
    UniProtKB/TrEMBL
    Q3UGL7, Q8CFB8
    Related
    ENSMUSP00000064513.8, ENSMUST00000067218.14
    Conserved Domains (2) summary
    cd01437
    Location:176527
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    cl01581
    Location:56154
    WGR; WGR domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106347521..106354148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511719.4XP_006511782.1  protein mono-ADP-ribosyltransferase PARP3 isoform X1

    See identical proteins and their annotated locations for XP_006511782.1

    UniProtKB/Swiss-Prot
    A0A1L1SRP6, E9PX17, E9Q992, Q3UGL7, Q3ULW8, Q8BHN6, Q8BXU2, Q8CFB8, Q91YR6
    Conserved Domains (2) summary
    cd01437
    Location:181532
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    cl01581
    Location:56154
    WGR; WGR domain
  2. XM_006511720.2XP_006511783.1  protein mono-ADP-ribosyltransferase PARP3 isoform X2

    See identical proteins and their annotated locations for XP_006511783.1

    UniProtKB/TrEMBL
    Q8CFB8
    Related
    ENSMUSP00000123054.2, ENSMUST00000123555.8
    Conserved Domains (2) summary
    cd01437
    Location:176527
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    cl01581
    Location:56154
    WGR; WGR domain
  3. XM_006511718.1XP_006511781.1  protein mono-ADP-ribosyltransferase PARP3 isoform X1

    See identical proteins and their annotated locations for XP_006511781.1

    UniProtKB/Swiss-Prot
    A0A1L1SRP6, E9PX17, E9Q992, Q3UGL7, Q3ULW8, Q8BHN6, Q8BXU2, Q8CFB8, Q91YR6
    Conserved Domains (2) summary
    cd01437
    Location:181532
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    cl01581
    Location:56154
    WGR; WGR domain

RNA

  1. XR_004935426.1 RNA Sequence