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PARP3 poly(ADP-ribose) polymerase family member 3 [ Homo sapiens (human) ]

Gene ID: 10039, updated on 13-Jan-2019

Summary

Official Symbol
PARP3provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 3provided by HGNC
Primary source
HGNC:HGNC:273
See related
Ensembl:ENSG00000041880 MIM:607726
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3
Summary
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 12.4), small intestine (RPKM 11.6) and 24 other tissues See more
Orthologs

Genomic context

See PARP3 in Genome Data Viewer
Location:
3p21.2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (51942277..51948867)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51976297..51982883)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene IQ motif containing F1 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene G protein-coupled receptor 62 Neighboring gene poly(rC) binding protein 4 Neighboring gene abhydrolase domain containing 14B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • BER complex, organism-specific biosystem (from KEGG)
    BER complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
  • BER complex, conserved biosystem (from KEGG)
    BER complex, conserved biosystemStructural complex; Genetic information processing; Repair system
  • Base excision repair, organism-specific biosystem (from KEGG)
    Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
  • Base excision repair, conserved biosystem (from KEGG)
    Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
catalytic activity TAS
Traceable Author Statement
more info
PubMed 
protein ADP-ribosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
DNA repair TAS
Traceable Author Statement
more info
PubMed 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of telomerase RNA reverse transcriptase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA ligation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of double-strand break repair via nonhomologous end joining IDA
Inferred from Direct Assay
more info
PubMed 
protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to site of double-strand break IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centriole IEA
Inferred from Electronic Annotation
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
poly [ADP-ribose] polymerase 3
Names
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3
ADP-ribosyltransferase diphtheria toxin-like 3
ADPRT-3
NAD(+) ADP-ribosyltransferase 3
NAD+ ADP-ribosyltransferase 3
poly(ADP-ribose) synthetase-3
poly[ADP-ribose] synthase 3
poly[ADP-ribose] synthetase 3
NP_001003931.3
NP_005476.4
XP_005264836.2
XP_016860979.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003931.3NP_001003931.3  poly [ADP-ribose] polymerase 3 isoform a

    See identical proteins and their annotated locations for NP_001003931.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript, but encodes the longer isoform (a).
    Source sequence(s)
    CA309713, CA394313, Y16836
    Consensus CDS
    CCDS46839.1
    UniProtKB/Swiss-Prot
    Q9Y6F1
    Related
    ENSP00000381740.3, ENST00000398755.7
    Conserved Domains (3) summary
    cd08002
    Location:65164
    WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
    cd01437
    Location:189539
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    pfam00644
    Location:337539
    PARP; Poly(ADP-ribose) polymerase catalytic domain
  2. NM_005485.5NP_005476.4  poly [ADP-ribose] polymerase 3 isoform b

    See identical proteins and their annotated locations for NP_005476.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    BI554046, CA309713, CA394313, Y16836
    Consensus CDS
    CCDS43097.1
    UniProtKB/Swiss-Prot
    Q9Y6F1
    UniProtKB/TrEMBL
    A0A024R2X5
    Related
    ENSP00000401511.1, ENST00000431474.5
    Conserved Domains (2) summary
    cd08002
    Location:58157
    WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
    cd01437
    Location:182532
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    51942277..51948867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264779.5XP_005264836.2  poly [ADP-ribose] polymerase 3 isoform X1

    See identical proteins and their annotated locations for XP_005264836.2

    UniProtKB/Swiss-Prot
    Q9Y6F1
    UniProtKB/TrEMBL
    A0A024R2X5
    Related
    ENSP00000395951.2, ENST00000417220.6
    Conserved Domains (2) summary
    cd08002
    Location:58157
    WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
    cd01437
    Location:182532
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
  2. XM_017005490.1XP_016860979.1  poly [ADP-ribose] polymerase 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y6F1
    UniProtKB/TrEMBL
    A0A024R2X5
    Conserved Domains (2) summary
    cd08002
    Location:58157
    WGR_PARP3_like; WGR domain of poly(ADP-ribose) polymerase 3 and similar proteins
    cd01437
    Location:182532
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003935.2: Suppressed sequence

    Description
    NM_001003935.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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