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LILRA4 leukocyte immunoglobulin like receptor A4 [ Homo sapiens (human) ]

Gene ID: 23547, updated on 22-Jun-2021

Summary

Official Symbol
LILRA4provided by HGNC
Official Full Name
leukocyte immunoglobulin like receptor A4provided by HGNC
Primary source
HGNC:HGNC:15503
See related
Ensembl:ENSG00000239961 MIM:607517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILT7; CD85g
Summary
This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]
Expression
Biased expression in spleen (RPKM 5.0), lymph node (RPKM 4.4) and 6 other tissues See more
Orthologs
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Genomic context

See LILRA4 in Genome Data Viewer
Location:
19q13.42
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (54333185..54339162, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54844456..54850433, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor A5 Neighboring gene vomeronasal 1 receptor 104 pseudogene Neighboring gene leukocyte associated immunoglobulin like receptor 1 Neighboring gene tweety family member 1 Neighboring gene Sharpr-MPRA regulatory region 3780

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu Vpu-mediated suppresion of IFN-1 production requires engagement and activation of the LILRA4 (ILT7) plasmacytoid dendritic cell receptor by BST2 PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Potential readthrough

Included gene: LILRA5

Homology

Clone Names

  • MGC129597, MGC129598

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables coreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Fc-epsilon receptor I complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leukocyte immunoglobulin-like receptor subfamily A member 4
Names
CD85 antigen-like family member G
immunoglobulin-like transcript 7
leucocyte Ig-like receptor A4
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012276.5NP_036408.4  leukocyte immunoglobulin-like receptor subfamily A member 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC245884, AF283989, BI834628, DA983933
    Consensus CDS
    CCDS12890.1
    UniProtKB/Swiss-Prot
    P59901
    Related
    ENSP00000291759.4, ENST00000291759.5
    Conserved Domains (2) summary
    smart00410
    Location:233295
    IG_like; Immunoglobulin like
    cl11960
    Location:122217
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    54333185..54339162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    314530..320509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p13 ALT_REF_LOCI_8

    Range
    314684..320663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p13 ALT_REF_LOCI_9

    Range
    315570..321547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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