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LILRA5 leukocyte immunoglobulin like receptor A5 [ Homo sapiens (human) ]

Gene ID: 353514, updated on 13-Feb-2019

Summary

Official Symbol
LILRA5provided by HGNC
Official Full Name
leukocyte immunoglobulin like receptor A5provided by HGNC
Primary source
HGNC:HGNC:16309
See related
Ensembl:ENSG00000187116 MIM:606047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD85; LIR9; CD85F; ILT11; LIR-9; ILT-11; LILRB7
Summary
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 29.5), bone marrow (RPKM 22.9) and 4 other tissues See more
Orthologs

Genomic context

See LILRA5 in Genome Data Viewer
Location:
19q13.42
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (54307070..54313139, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54818353..54824409, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B2 Neighboring gene microRNA 4752 Neighboring gene vomeronasal 1 receptor 104 pseudogene Neighboring gene leukocyte immunoglobulin like receptor A4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...

General gene information

Markers

Potential readthrough

Included gene: LILRA4

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leukocyte immunoglobulin-like receptor subfamily A member 5
Names
CD85 antigen-like family member F
immunoglobulin-like transcript 11 protein
leucocyte Ig-like receptor A5
leukocyte Ig-like receptor 9
leukocyte immunoglobulin-like receptor 9
leukocyte immunoglobulin-like receptor subfamily A member 5 soluble
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021250.3NP_067073.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as LIR9m1, encodes the longest isoform (1).
    Source sequence(s)
    AC245884, AF324830, AF499916
    Consensus CDS
    CCDS12888.1
    UniProtKB/Swiss-Prot
    A6NI73
    Related
    ENSP00000404236.4, ENST00000432233.7
    Conserved Domains (2) summary
    cd05711
    Location:141236
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:45136
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
  2. NM_181879.2NP_870994.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 3

    See identical proteins and their annotated locations for NP_870994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as LIR9s1, differs in the 3' end-region, which includes a part of the coding region, as compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC245884, AF324830, AF499918, AF499919
    UniProtKB/Swiss-Prot
    A6NI73
    Conserved Domains (2) summary
    cd05711
    Location:141236
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:45136
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
  3. NM_181985.3NP_871714.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 2

    See identical proteins and their annotated locations for NP_871714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as LIR9m2, lacks an in-frame coding segment, as compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AC245884, AF324830, AF499917
    Consensus CDS
    CCDS12889.1
    UniProtKB/Swiss-Prot
    A6NI73
    Related
    ENSP00000484372.1, ENST00000486742.2
    Conserved Domains (2) summary
    cd05711
    Location:129224
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:33124
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
  4. NM_181986.2NP_871715.1  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 4

    See identical proteins and their annotated locations for NP_871715.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as LIR9s2, lacks an in-frame coding segment and differs in the 3' end-region, as compared to variant 1. The resulting isoform (4) lacks an internal region and has a distinct and shorter C-terminus as compared to isoform 1.
    Source sequence(s)
    AC245884, AF324830, AF499919
    UniProtKB/Swiss-Prot
    A6NI73
    Conserved Domains (2) summary
    cd05711
    Location:129224
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cd05751
    Location:33124
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    54307070..54313139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    288498..294554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    288422..294485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p12 ALT_REF_LOCI_8

    Range
    288603..294640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p12 ALT_REF_LOCI_9

    Range
    289467..295523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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