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MTREX Mtr4 exosome RNA helicase [ Homo sapiens (human) ]

Gene ID: 23517, updated on 26-Sep-2021

Summary

Official Symbol
MTREXprovided by HGNC
Official Full Name
Mtr4 exosome RNA helicaseprovided by HGNC
Primary source
HGNC:HGNC:18734
See related
Ensembl:ENSG00000039123 MIM:618122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Dob1; Mtr4; SKIV2L2; fSAP118; KIAA0052
Expression
Ubiquitous expression in prostate (RPKM 29.9), gall bladder (RPKM 23.3) and 25 other tissues See more
Orthologs
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Genomic context

See MTREX in Genome Data Viewer
Location:
5q11.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (55307989..55425579)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54603817..54721407)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cyclin O Neighboring gene uncharacterized LOC105378973 Neighboring gene DExH-box helicase 29 Neighboring gene protein serine kinase H1 pseudogene Neighboring gene uncharacterized LOC107986415 Neighboring gene phospholipid phosphatase 1 Neighboring gene microRNA 5687 Neighboring gene ring finger protein 138 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, superkiller viralicidic activity 2-like 2 (SKIV2L2), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142069

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in RNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in maturation of 5.8S rRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in snRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of TRAMP complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exosome RNA helicase MTR4
Names
ATP-dependent RNA helicase DOB1
ATP-dependent RNA helicase SKIV2L2
ATP-dependent helicase SKIV2L2
Ski2 like RNA helicase 2
TRAMP-like complex helicase
functional spliceosome-associated protein 118
superkiller viralicidic activity 2-like 2
NP_056175.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015360.5NP_056175.3  exosome RNA helicase MTR4

    See identical proteins and their annotated locations for NP_056175.3

    Status: VALIDATED

    Source sequence(s)
    BC065258, BX640789
    Consensus CDS
    CCDS3967.1
    UniProtKB/Swiss-Prot
    P42285
    UniProtKB/TrEMBL
    Q3MHC9
    Related
    ENSP00000230640.5, ENST00000230640.10
    Conserved Domains (5) summary
    COG4581
    Location:681042
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cd00079
    Location:374538
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:144287
    DEAD; DEAD/DEAH box helicase
    pfam08148
    Location:8681035
    DSHCT; DSHCT (NUC185) domain
    pfam13234
    Location:584840
    rRNA_proc-arch; rRNA-processing arch domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    55307989..55425579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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