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Mtrex Mtr4 exosome RNA helicase [ Mus musculus (house mouse) ]

Gene ID: 72198, updated on 26-Sep-2022

Summary

Official Symbol
Mtrexprovided by MGI
Official Full Name
Mtr4 exosome RNA helicaseprovided by MGI
Primary source
MGI:MGI:1919448
See related
Ensembl:ENSMUSG00000016018 AllianceGenome:MGI:1919448
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Skiv2l2; mKIAA0052; 2610528A15Rik
Summary
Predicted to enable ATP binding activity and RNA helicase activity. Predicted to be involved in RNA catabolic process; cellular response to DNA damage stimulus; and maturation of 5.8S rRNA. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of TRAMP complex; catalytic step 2 spliceosome; and nuclear exosome (RNase complex). Predicted to be active in nucleus. Orthologous to human MTREX (Mtr4 exosome RNA helicase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 25.7), CNS E14 (RPKM 16.5) and 24 other tissues See more
Orthologs
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Genomic context

See Mtrex in Genome Data Viewer
Location:
13; 13 D2.2
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113004306..113063914, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112867780..112927380, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 38, member 9 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene Neighboring gene predicted gene, 41067 Neighboring gene phospholipid phosphatase 1 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 29 Neighboring gene 40S ribosomal protein S13-like Neighboring gene cyclin O

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in maturation of 5.8S rRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of TRAMP complex ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
exosome RNA helicase MTR4
Names
ATP-dependent helicase SKIV2L2
TRAMP-like complex helicase
superkiller viralicidic activity 2-like 2
NP_082427.1
XP_036014071.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028151.2NP_082427.1  exosome RNA helicase MTR4

    See identical proteins and their annotated locations for NP_082427.1

    Status: PROVISIONAL

    Source sequence(s)
    AC165265
    Consensus CDS
    CCDS26778.1
    UniProtKB/Swiss-Prot
    Q9CZU3
    Related
    ENSMUSP00000022281.4, ENSMUST00000022281.5
    Conserved Domains (5) summary
    COG4581
    Location:921040
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cd00079
    Location:372536
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:142285
    DEAD; DEAD/DEAH box helicase
    pfam08148
    Location:8661033
    DSHCT; DSHCT (NUC185) domain
    pfam13234
    Location:582838
    rRNA_proc-arch; rRNA-processing arch domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    113004306..113063914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158178.1XP_036014071.1  exosome RNA helicase MTR4 isoform X1

    Conserved Domains (1) summary
    COG4581
    Location:16696
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]