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SLC39A14 solute carrier family 39 member 14 [ Homo sapiens (human) ]

Gene ID: 23516, updated on 29-Mar-2020

Summary

Official Symbol
SLC39A14provided by HGNC
Official Full Name
solute carrier family 39 member 14provided by HGNC
Primary source
HGNC:HGNC:20858
See related
Ensembl:ENSG00000104635 MIM:608736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCIN; NET34; ZIP14; cig19; HMNDYT2; LZT-Hs4
Summary
This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]
Expression
Broad expression in liver (RPKM 83.2), duodenum (RPKM 51.4) and 20 other tissues See more
Orthologs

Genomic context

See SLC39A14 in Genome Data Viewer
Location:
8p21.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22367278..22434129)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22224762..22291642)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507071 Neighboring gene RNA polymerase III subunit D Neighboring gene piwi like RNA-mediated gene silencing 2 Neighboring gene ribosomal protein L21 pseudogene 77 Neighboring gene RNA, U6 small nuclear 336, pseudogene Neighboring gene protein phosphatase 3 catalytic subunit gamma Neighboring gene BTF3 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of solute carrier family 39, member 14 (SLC39A14) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0062

Gene Ontology Provided by GOA

Function Evidence Code Pubs
anion:cation symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cadmium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ferrous iron transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
iron ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
manganese ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cadmium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular zinc ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
iron assimilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
iron ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
manganese ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
manganese ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cyclic-nucleotide phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of hormone levels ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc transporter ZIP14
Names
LIV-1 subfamily of ZIP zinc transporter 4
Zrt-, Irt-like protein 14
solute carrier family 39 (metal ion transporter), member 14
solute carrier family 39 (zinc transporter), member 14
zrt- and Irt-like protein 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054890.1 RefSeqGene

    Range
    5030..60488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128431.4NP_001121903.1  zinc transporter ZIP14 isoform a precursor

    See identical proteins and their annotated locations for NP_001121903.1

    Status: REVIEWED

    Source sequence(s)
    AA181885, AK172810, D31887, DC323208
    Consensus CDS
    CCDS47823.1
    UniProtKB/Swiss-Prot
    Q15043
    Related
    ENSP00000370635.1, ENST00000381237.6
    Conserved Domains (1) summary
    pfam02535
    Location:151483
    Zip; ZIP Zinc transporter
  2. NM_001135153.3NP_001128625.1  zinc transporter ZIP14 isoform a precursor

    See identical proteins and their annotated locations for NP_001128625.1

    Status: REVIEWED

    Source sequence(s)
    AA181885, AC087854, AK295807, DC423882
    Consensus CDS
    CCDS47823.1
    UniProtKB/Swiss-Prot
    Q15043
    Related
    ENSP00000289952.5, ENST00000289952.9
    Conserved Domains (1) summary
    pfam02535
    Location:151483
    Zip; ZIP Zinc transporter
  3. NM_001135154.3NP_001128626.1  zinc transporter ZIP14 isoform c precursor

    See identical proteins and their annotated locations for NP_001128626.1

    Status: REVIEWED

    Source sequence(s)
    BC015770, DC323208
    Consensus CDS
    CCDS47822.1
    UniProtKB/TrEMBL
    A0A0S2Z534
    Related
    ENSP00000240095.6, ENST00000240095.10
    Conserved Domains (2) summary
    pfam02535
    Location:151445
    Zip; ZIP Zinc transporter
    pfam13900
    Location:450480
    GVQW; Putative domain of unknown function
  4. NM_001351655.2NP_001338584.1  zinc transporter ZIP14 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AA181885, AC087854, AC105910
    Consensus CDS
    CCDS47823.1
    Conserved Domains (1) summary
    pfam02535
    Location:151483
    Zip; ZIP Zinc transporter
  5. NM_001351656.2NP_001338585.1  zinc transporter ZIP14 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AA181885, AC087854, AC105910
    Consensus CDS
    CCDS47823.1
    Conserved Domains (1) summary
    pfam02535
    Location:151483
    Zip; ZIP Zinc transporter
  6. NM_001351657.2NP_001338586.1  zinc transporter ZIP14 isoform d

    Status: REVIEWED

    Source sequence(s)
    AA181885, AC087854, AC105910
    Conserved Domains (1) summary
    pfam02535
    Location:161493
    Zip; ZIP Zinc transporter
  7. NM_001351658.2NP_001338587.1  zinc transporter ZIP14 isoform d

    Status: REVIEWED

    Source sequence(s)
    AA181885, AC087854, AC105910
    Conserved Domains (1) summary
    pfam02535
    Location:161493
    Zip; ZIP Zinc transporter
  8. NM_001351659.2NP_001338588.1  zinc transporter ZIP14 isoform d

    Status: REVIEWED

    Source sequence(s)
    AA181885, AC087854, AC105910, DC369996
    Conserved Domains (1) summary
    pfam02535
    Location:161493
    Zip; ZIP Zinc transporter
  9. NM_001351660.2NP_001338589.1  zinc transporter ZIP14 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AA181885, AC087854, AC105910
    Consensus CDS
    CCDS47823.1
    Conserved Domains (1) summary
    pfam02535
    Location:151483
    Zip; ZIP Zinc transporter
  10. NM_015359.6NP_056174.2  zinc transporter ZIP14 isoform b precursor

    See identical proteins and their annotated locations for NP_056174.2

    Status: REVIEWED

    Source sequence(s)
    AA181885, AK172810, D31887, DC323208
    Consensus CDS
    CCDS6030.1
    UniProtKB/Swiss-Prot
    Q15043
    Related
    ENSP00000352779.5, ENST00000359741.9
    Conserved Domains (1) summary
    pfam02535
    Location:151483
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    22367278..22434129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013293.2XP_016868782.1  zinc transporter ZIP14 isoform X1

  2. XM_006716324.3XP_006716387.1  zinc transporter ZIP14 isoform X2

    See identical proteins and their annotated locations for XP_006716387.1

    UniProtKB/Swiss-Prot
    Q15043
    Conserved Domains (1) summary
    pfam02535
    Location:151483
    Zip; ZIP Zinc transporter
  3. XM_011544478.3XP_011542780.1  zinc transporter ZIP14 isoform X2

    See identical proteins and their annotated locations for XP_011542780.1

    UniProtKB/Swiss-Prot
    Q15043
    Conserved Domains (1) summary
    pfam02535
    Location:151483
    Zip; ZIP Zinc transporter
  4. XM_005273466.4XP_005273523.1  zinc transporter ZIP14 isoform X2

    See identical proteins and their annotated locations for XP_005273523.1

    UniProtKB/Swiss-Prot
    Q15043
    Conserved Domains (1) summary
    pfam02535
    Location:151483
    Zip; ZIP Zinc transporter
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