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Slc39a14 solute carrier family 39 (zinc transporter), member 14 [ Mus musculus (house mouse) ]

Gene ID: 213053, updated on 9-Mar-2023

Summary

Official Symbol
Slc39a14provided by MGI
Official Full Name
solute carrier family 39 (zinc transporter), member 14provided by MGI
Primary source
MGI:MGI:2384851
See related
Ensembl:ENSMUSG00000022094 AllianceGenome:MGI:2384851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zip14; ZIP-14; fad123; FAD-123
Summary
Enables anion:cation symporter activity and transition metal ion transmembrane transporter activity. Involved in several processes, including negative regulation of cyclic-nucleotide phosphodiesterase activity; transition metal ion homeostasis; and transition metal ion transport. Acts upstream of or within iron ion transport and zinc ion transport. Located in basolateral plasma membrane. Is expressed in autopod; ear; face; nervous system; and skeleton. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 2. Orthologous to human SLC39A14 (solute carrier family 39 member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 12.6), liver E18 (RPKM 11.1) and 28 other tissues See more
Orthologs
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Genomic context

See Slc39a14 in Genome Data Viewer
Location:
14; 14 D2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70540916..70588873, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70303467..70351452, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 3, catalytic subunit, gamma isoform Neighboring gene predicted gene, 33790 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene cell division cycle 26 pseudogene Neighboring gene piwi-like RNA-mediated gene silencing 2 Neighboring gene predicted gene, 22725

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC38539, G630015O18Rik

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in inorganic cation transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in iron import into cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in iron import into cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within iron ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in iron ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in iron ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in iron ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within iron ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in manganese ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in manganese ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in manganese ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cyclic-nucleotide phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of regulation of hormone levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in zinc ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within zinc ion transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metal cation symporter ZIP14
Names
Zrt- and Irt-like protein 14
factor for adipocyte differentiation 123
zinc transporter ZIP14

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135151.1NP_001128623.1  metal cation symporter ZIP14 isoform a precursor

    See identical proteins and their annotated locations for NP_001128623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC025669
    Consensus CDS
    CCDS49536.1
    UniProtKB/Swiss-Prot
    Q75N73
    UniProtKB/TrEMBL
    A0A0R4J1V1
    Related
    ENSMUSP00000022688.4, ENSMUST00000022688.10
    Conserved Domains (1) summary
    pfam02535
    Location:150480
    Zip; ZIP Zinc transporter
  2. NM_001135152.1NP_001128624.1  metal cation symporter ZIP14 isoform a precursor

    See identical proteins and their annotated locations for NP_001128624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC025669, AK050076, AK090193
    Consensus CDS
    CCDS49536.1
    UniProtKB/Swiss-Prot
    Q75N73
    UniProtKB/TrEMBL
    A0A0R4J1V1
    Related
    ENSMUSP00000119040.2, ENSMUST00000152067.8
    Conserved Domains (1) summary
    pfam02535
    Location:150480
    Zip; ZIP Zinc transporter
  3. NM_144808.4NP_659057.2  metal cation symporter ZIP14 isoform b precursor

    See identical proteins and their annotated locations for NP_659057.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon and contains an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is the same length as isoform a, but contains a distinct internal segment.
    Source sequence(s)
    AC025669, AK090193, AK158096, BY253316, CB521415
    Consensus CDS
    CCDS36969.1
    UniProtKB/Swiss-Prot
    Q75N73, Q8VDL0
    Related
    ENSMUSP00000066108.8, ENSMUST00000068044.14
    Conserved Domains (1) summary
    pfam02535
    Location:150480
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70540916..70588873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247713.2XP_030103573.1  metal cation symporter ZIP14 isoform X5

    UniProtKB/Swiss-Prot
    Q8VDL0
    Conserved Domains (1) summary
    pfam02535
    Location:150480
    Zip; ZIP Zinc transporter
  2. XM_006518786.5XP_006518849.1  metal cation symporter ZIP14 isoform X2

    Conserved Domains (1) summary
    pfam02535
    Location:202532
    Zip; ZIP Zinc transporter
  3. XM_006518787.5XP_006518850.1  metal cation symporter ZIP14 isoform X3

    Conserved Domains (1) summary
    pfam02535
    Location:202523
    Zip; ZIP Zinc transporter
  4. XM_030247712.2XP_030103572.1  metal cation symporter ZIP14 isoform X1

    Conserved Domains (1) summary
    pfam02535
    Location:202532
    Zip; ZIP Zinc transporter
  5. XM_030247714.1XP_030103574.1  metal cation symporter ZIP14 isoform X6

    Conserved Domains (1) summary
    pfam02535
    Location:6313
    Zip; ZIP Zinc transporter
  6. XM_030247717.1XP_030103577.1  metal cation symporter ZIP14 isoform X6

    Conserved Domains (1) summary
    pfam02535
    Location:6313
    Zip; ZIP Zinc transporter
  7. XM_006518789.3XP_006518852.1  metal cation symporter ZIP14 isoform X4

    See identical proteins and their annotated locations for XP_006518852.1

    UniProtKB/Swiss-Prot
    Q75N73
    UniProtKB/TrEMBL
    A0A0R4J1V1
    Conserved Domains (1) summary
    pfam02535
    Location:150480
    Zip; ZIP Zinc transporter
  8. XM_030247715.1XP_030103575.1  metal cation symporter ZIP14 isoform X6

    Conserved Domains (1) summary
    pfam02535
    Location:6313
    Zip; ZIP Zinc transporter
  9. XM_006518788.3XP_006518851.1  metal cation symporter ZIP14 isoform X4

    See identical proteins and their annotated locations for XP_006518851.1

    UniProtKB/Swiss-Prot
    Q75N73
    UniProtKB/TrEMBL
    A0A0R4J1V1
    Conserved Domains (1) summary
    pfam02535
    Location:150480
    Zip; ZIP Zinc transporter
  10. XM_030247716.1XP_030103576.1  metal cation symporter ZIP14 isoform X6

    Conserved Domains (1) summary
    pfam02535
    Location:6313
    Zip; ZIP Zinc transporter
  11. XM_006518791.1XP_006518854.1  metal cation symporter ZIP14 isoform X6

    Conserved Domains (1) summary
    pfam02535
    Location:6313
    Zip; ZIP Zinc transporter