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Zfp646 zinc finger protein 646 [ Mus musculus (house mouse) ]

Gene ID: 233905, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp646provided by MGI
Official Full Name
zinc finger protein 646provided by MGI
Primary source
MGI:MGI:3665412
See related
Ensembl:ENSMUSG00000049739 AllianceGenome:MGI:3665412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6820429M01
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF646 (zinc finger protein 646). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 22.7), thymus adult (RPKM 14.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp646 in Genome Data Viewer
Location:
7 F3; 7 69.8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127476081..127485168)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127876914..127885996)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3755 Neighboring gene syntaxin 4A (placental) Neighboring gene STARR-seq mESC enhancer starr_20194 Neighboring gene zinc finger protein 668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135020325-135020434 Neighboring gene serine protease 53 Neighboring gene vitamin K epoxide reductase complex, subunit 1 Neighboring gene branched chain ketoacid dehydrogenase kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 646

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404058.1 → NP_001390987.1  zinc finger protein 646

    Status: VALIDATED

    Source sequence(s)
    AC149222
    UniProtKB/Swiss-Prot
    Q6NV66

  2. NM_001404059.1 → NP_001390988.1  zinc finger protein 646

    Status: VALIDATED

    Source sequence(s)
    AC149222
    UniProtKB/Swiss-Prot
    Q6NV66

  3. NM_001404060.1 → NP_001390989.1  zinc finger protein 646

    Status: VALIDATED

    Source sequence(s)
    AC149222
    UniProtKB/Swiss-Prot
    Q6NV66

  4. NM_001404061.1 → NP_001390990.1  zinc finger protein 646

    Status: VALIDATED

    Source sequence(s)
    AC149222
    UniProtKB/Swiss-Prot
    Q6NV66

  5. NM_001404062.1 → NP_001390991.1  zinc finger protein 646

    Status: VALIDATED

    Source sequence(s)
    AC149222
    UniProtKB/Swiss-Prot
    Q6NV66

  6. NM_172749.4 → NP_766337.2  zinc finger protein 646

    See identical proteins and their annotated locations for NP_766337.2

    Status: VALIDATED

    Source sequence(s)
    BC068300, BC079907
    Consensus CDS
    CCDS21882.1
    UniProtKB/Swiss-Prot
    Q6NV66
    UniProtKB/TrEMBL
    A0A0U1RNR6
    Related
    ENSMUSP00000052641.8, ENSMUST00000050383.8
    Conserved Domains (2) summary
    sd00017
    Location:1172 → 1192
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1681 → 1706
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127476081..127485168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NV66.1 GenPept UniProtKB/Swiss-Prot:Q6NV66

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