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ZNF646 zinc finger protein 646 [ Homo sapiens (human) ]

Gene ID: 9726, updated on 1-Jun-2020

Summary

Official Symbol
ZNF646provided by HGNC
Official Full Name
zinc finger protein 646provided by HGNC
Primary source
HGNC:HGNC:29004
See related
Ensembl:ENSG00000167395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 13.8), spleen (RPKM 4.2) and 23 other tissues See more
Orthologs

Genomic context

See ZNF646 in Genome Data Viewer
Location:
16p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (31073665..31084196)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31085581..31094833)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928762 Neighboring gene syntaxin 4 Neighboring gene zinc finger protein 668 Neighboring gene serine protease 53 Neighboring gene vitamin K epoxide reductase complex subunit 1 Neighboring gene branched chain keto acid dehydrogenase kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014699.4NP_055514.3  zinc finger protein 646

    See identical proteins and their annotated locations for NP_055514.3

    Status: VALIDATED

    Source sequence(s)
    AC135050, BC035589
    Consensus CDS
    CCDS10702.1
    UniProtKB/Swiss-Prot
    O15015
    Related
    ENSP00000300850.5, ENST00000300850.5
    Conserved Domains (3) summary
    COG5048
    Location:222419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:12321252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:17181743
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    31073665..31084196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255710.4XP_005255767.1  zinc finger protein 646 isoform X1

    See identical proteins and their annotated locations for XP_005255767.1

    UniProtKB/Swiss-Prot
    O15015
    Conserved Domains (3) summary
    COG5048
    Location:222419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:12321252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:17181743
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005255711.4XP_005255768.1  zinc finger protein 646 isoform X1

    See identical proteins and their annotated locations for XP_005255768.1

    UniProtKB/Swiss-Prot
    O15015
    Conserved Domains (3) summary
    COG5048
    Location:222419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:12321252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:17181743
    zf-H2C2_2; Zinc-finger double domain
  3. XM_005255712.4XP_005255769.1  zinc finger protein 646 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:222419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:12321252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:17181743
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011545990.2XP_011544292.1  zinc finger protein 646 isoform X1

    See identical proteins and their annotated locations for XP_011544292.1

    UniProtKB/Swiss-Prot
    O15015
    Conserved Domains (3) summary
    COG5048
    Location:222419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:12321252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:17181743
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_001752041.1 RNA Sequence

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