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ZNF646 zinc finger protein 646 [ Homo sapiens (human) ]

Gene ID: 9726, updated on 6-Sep-2022

Summary

Official Symbol
ZNF646provided by HGNC
Official Full Name
zinc finger protein 646provided by HGNC
Primary source
HGNC:HGNC:29004
See related
Ensembl:ENSG00000167395 MIM:619299; AllianceGenome:HGNC:29004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 13.8), spleen (RPKM 4.2) and 23 other tissues See more
Orthologs
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Genomic context

See ZNF646 in Genome Data Viewer
Location:
16p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31072687..31084196)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31461850..31471624)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31085743..31095517)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene syntaxin 1B Neighboring gene syntaxin 4 Neighboring gene zinc finger protein 668 Neighboring gene Sharpr-MPRA regulatory region 2047 Neighboring gene serine protease 53 Neighboring gene zinc finger protein ENSP00000375192-like Neighboring gene vitamin K epoxide reductase complex subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014699.4NP_055514.3  zinc finger protein 646

    See identical proteins and their annotated locations for NP_055514.3

    Status: VALIDATED

    Source sequence(s)
    AC135050, BC035589
    Consensus CDS
    CCDS10702.1
    UniProtKB/Swiss-Prot
    O15015, Q8IVD8
    Related
    ENSP00000300850.5, ENST00000300850.5
    Conserved Domains (3) summary
    sd00017
    Location:12321252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:7597
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:17181743
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    31072687..31084196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434956.1XP_047290912.1  zinc finger protein 646 isoform X1

    UniProtKB/Swiss-Prot
    Q8IVD8
  2. XM_011545990.3XP_011544292.1  zinc finger protein 646 isoform X1

    See identical proteins and their annotated locations for XP_011544292.1

    UniProtKB/Swiss-Prot
    O15015, Q8IVD8
    Conserved Domains (3) summary
    sd00017
    Location:12321252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:7597
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:17181743
    zf-H2C2_2; Zinc-finger double domain
  3. XM_005255712.5XP_005255769.1  zinc finger protein 646 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:222419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:12321252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:17181743
    zf-H2C2_2; Zinc-finger double domain
  4. XM_005255710.5XP_005255767.1  zinc finger protein 646 isoform X1

    See identical proteins and their annotated locations for XP_005255767.1

    UniProtKB/Swiss-Prot
    O15015, Q8IVD8
    Conserved Domains (3) summary
    sd00017
    Location:12321252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:7597
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:17181743
    zf-H2C2_2; Zinc-finger double domain
  5. XM_047434957.1XP_047290913.1  zinc finger protein 646 isoform X2

  6. XM_005255711.5XP_005255768.1  zinc finger protein 646 isoform X1

    See identical proteins and their annotated locations for XP_005255768.1

    UniProtKB/Swiss-Prot
    O15015, Q8IVD8
    Conserved Domains (3) summary
    sd00017
    Location:12321252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:7597
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:17181743
    zf-H2C2_2; Zinc-finger double domain
  7. XM_047434958.1XP_047290914.1  zinc finger protein 646 isoform X2

RNA

  1. XR_001752041.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    31461850..31471624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)