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PUM2 pumilio RNA binding family member 2 [ Homo sapiens (human) ]

Gene ID: 23369, updated on 1-Jun-2020

Summary

Official Symbol
PUM2provided by HGNC
Official Full Name
pumilio RNA binding family member 2provided by HGNC
Primary source
HGNC:HGNC:14958
See related
Ensembl:ENSG00000055917 MIM:607205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PUMH2; PUML2
Summary
This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.6) and 25 other tissues See more
Orthologs

Genomic context

See PUM2 in Genome Data Viewer
Location:
2p24.1
Exon count:
28
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (20248691..20352253, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (20448453..20550585, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene DRG1 pseudogene 1 Neighboring gene RNA, U7 small nuclear 113 pseudogene Neighboring gene RP9, pre-mRNA splicing factor pseudogene Neighboring gene solute carrier family 7 member 15, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 86

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with pumilio homolog 2 (PUM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36528, KIAA0235, MGC138251, MGC138253

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of RIG-I signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
posttranscriptional regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
posttranscriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
posttranscriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
production of miRNAs involved in gene silencing by miRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
production of miRNAs involved in gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of chromosome segregation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
PubMed 
regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
stress granule assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pumilio homolog 2
Names
pumilio-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282752.2NP_001269681.1  pumilio homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001269681.1

    Status: REVIEWED

    Source sequence(s)
    AC007041, AF315591, AK304198, BG717417, BX094307
    Consensus CDS
    CCDS74487.1
    UniProtKB/Swiss-Prot
    Q8TB72
    Related
    ENSP00000354370.3, ENST00000361078.6
    Conserved Domains (1) summary
    cd07920
    Location:665986
    Pumilio; Pumilio-family RNA binding domain
  2. NM_001282790.2NP_001269719.1  pumilio homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_001269719.1

    Status: REVIEWED

    Source sequence(s)
    AC007041, AF315591, BC143550, BX094307
    UniProtKB/TrEMBL
    B7ZL34
    Conserved Domains (1) summary
    cd07920
    Location:642963
    Pumilio; Pumilio-family RNA binding domain
  3. NM_001282791.2NP_001269720.1  pumilio homolog 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC007041, AF272350, AF315591, BC143552, BX094307
    Consensus CDS
    CCDS74486.1
    UniProtKB/TrEMBL
    A0A0A0MR59
    Related
    ENSP00000326746.6, ENST00000319801.9
    Conserved Domains (1) summary
    cd07920
    Location:586907
    Pumilio; Pumilio-family RNA binding domain
  4. NM_001352917.2NP_001339846.1  pumilio homolog 2 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC007041
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  5. NM_001352918.1NP_001339847.1  pumilio homolog 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC007041, BX094307
    Consensus CDS
    CCDS1698.1
    Conserved Domains (1) summary
    cd07920
    Location:7211042
    Pumilio; Pumilio-family RNA binding domain
  6. NM_001352919.2NP_001339848.1  pumilio homolog 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC007041
    Consensus CDS
    CCDS1698.1
    Related
    ENSP00000338173.5, ENST00000338086.9
    Conserved Domains (1) summary
    cd07920
    Location:7211042
    Pumilio; Pumilio-family RNA binding domain
  7. NM_001352920.2NP_001339849.1  pumilio homolog 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC007041
    Conserved Domains (1) summary
    cd07920
    Location:642965
    Pumilio; Pumilio-family RNA binding domain
  8. NM_001352923.2NP_001339852.1  pumilio homolog 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC007041
    Conserved Domains (1) summary
    cd07920
    Location:642965
    Pumilio; Pumilio-family RNA binding domain
  9. NM_001352925.2NP_001339854.1  pumilio homolog 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007041
    Conserved Domains (1) summary
    cd07920
    Location:642963
    Pumilio; Pumilio-family RNA binding domain
  10. NM_001352926.1NP_001339855.1  pumilio homolog 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007041, BX094307
    Conserved Domains (1) summary
    cd07920
    Location:642963
    Pumilio; Pumilio-family RNA binding domain
  11. NM_001352927.2NP_001339856.1  pumilio homolog 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007041
    Conserved Domains (1) summary
    cd07920
    Location:642963
    Pumilio; Pumilio-family RNA binding domain
  12. NM_001352928.2NP_001339857.1  pumilio homolog 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC007041
    Conserved Domains (1) summary
    cd07920
    Location:642963
    Pumilio; Pumilio-family RNA binding domain
  13. NM_001352929.2NP_001339858.1  pumilio homolog 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC007041
    Consensus CDS
    CCDS74486.1
    Conserved Domains (1) summary
    cd07920
    Location:586907
    Pumilio; Pumilio-family RNA binding domain
  14. NM_001352930.2NP_001339859.1  pumilio homolog 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC007041
    Conserved Domains (1) summary
    cd07920
    Location:495816
    Pumilio; Pumilio-family RNA binding domain
  15. NM_015317.5NP_056132.1  pumilio homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_056132.1

    Status: REVIEWED

    Source sequence(s)
    AC007041, AF315591, AK093847, BG717417
    Consensus CDS
    CCDS1698.1
    UniProtKB/Swiss-Prot
    Q8TB72
    Related
    ENSP00000385992.1, ENST00000403432.5
    Conserved Domains (1) summary
    cd07920
    Location:7211042
    Pumilio; Pumilio-family RNA binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    20248691..20352253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711974.2XP_006712037.1  pumilio homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006712037.1

    UniProtKB/Swiss-Prot
    Q8TB72
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  2. XM_017003715.1XP_016859204.1  pumilio homolog 2 isoform X5

  3. XM_011532723.1XP_011531025.1  pumilio homolog 2 isoform X4

    Conserved Domains (1) summary
    cd07920
    Location:495818
    Pumilio; Pumilio-family RNA binding domain
  4. XM_005262609.1XP_005262666.1  pumilio homolog 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8TB72
    Conserved Domains (1) summary
    cd07920
    Location:642965
    Pumilio; Pumilio-family RNA binding domain
  5. XM_005262607.1XP_005262664.1  pumilio homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005262664.1

    UniProtKB/Swiss-Prot
    Q8TB72
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  6. XM_011532721.2XP_011531023.1  pumilio homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011531023.1

    UniProtKB/Swiss-Prot
    Q8TB72
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  7. XM_011532720.2XP_011531022.1  pumilio homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011531022.1

    UniProtKB/Swiss-Prot
    Q8TB72
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  8. XM_011532719.1XP_011531021.1  pumilio homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011531021.1

    UniProtKB/Swiss-Prot
    Q8TB72
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  9. XM_024452772.1XP_024308540.1  pumilio homolog 2 isoform X3

    Conserved Domains (1) summary
    cd07920
    Location:665988
    Pumilio; Pumilio-family RNA binding domain
  10. XM_024452773.1XP_024308541.1  pumilio homolog 2 isoform X8

    Conserved Domains (1) summary
    cd07920
    Location:258581
    Pumilio; Pumilio-family RNA binding domain
  11. XM_011532724.2XP_011531026.1  pumilio homolog 2 isoform X6

  12. XM_011532725.2XP_011531027.1  pumilio homolog 2 isoform X7

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