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Pum2 pumilio RNA-binding family member 2 [ Mus musculus (house mouse) ]

Gene ID: 80913, updated on 8-Dec-2022

Summary

Official Symbol
Pum2provided by MGI
Official Full Name
pumilio RNA-binding family member 2provided by MGI
Primary source
MGI:MGI:1931751
See related
Ensembl:ENSMUSG00000020594 AllianceGenome:MGI:1931751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pumm2; 5730503J23Rik
Summary
Enables RNA binding activity. Acts upstream of or within posttranscriptional regulation of gene expression and stress granule assembly. Located in cytoplasmic stress granule. Is expressed in several structures, including adipose tissue; alimentary system; immune system; nervous system; and reproductive system. Orthologous to human PUM2 (pumilio RNA binding family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 23.4), whole brain E14.5 (RPKM 23.1) and 28 other tissues See more
Orthologs
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Genomic context

See Pum2 in Genome Data Viewer
Location:
12; 12 A1.1
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (8724092..8802583)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (8674092..8752583)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5033421B08 gene Neighboring gene small nucleolar RNA SNORA48 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 Neighboring gene predicted gene 4755 Neighboring gene syndecan 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • mKIAA0235

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables lncRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pumilio-response element binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adipose tissue development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromosome organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hair follicle development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA-mediated gene silencing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in respiratory electron transport chain IDA
Inferred from Direct Assay
more info
PubMed 
involved_in skeletal system development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within stress granule assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within stress granule assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pumilio homolog 2
Names
pumilio 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160219.1NP_001153691.1  pumilio homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001153691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK147617, AY027917, BQ828592, CJ124920
    Consensus CDS
    CCDS25802.1
    UniProtKB/Swiss-Prot
    Q80U58, Q9ERC7
    Related
    ENSMUSP00000131074.2, ENSMUST00000163569.8
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  2. NM_001160220.1NP_001153692.1  pumilio homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001153692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame donor splice site in the 3' coding region compared to variant 1. This results in an isoform (2) lacking 2 aa compared to isoform 1. Variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AK141682, AK147617, BQ828592, CJ124920
    Consensus CDS
    CCDS49025.1
    UniProtKB/TrEMBL
    Q3UR91
    Related
    ENSMUSP00000106751.3, ENSMUST00000111122.9
    Conserved Domains (1) summary
    cd07920
    Location:7211042
    Pumilio; Pumilio-family RNA binding domain
  3. NM_001160221.1NP_001153693.1  pumilio homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001153693.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and uses an alternate in-frame donor splice site in the 3' coding region compared to variant 1. This results in an isoform (2) lacking 2 aa compared to isoform 1. Variants 3 and 4 encode the same isoform.
    Source sequence(s)
    AK134185, AK141682, AK147617, BQ828592
    Consensus CDS
    CCDS49025.1
    UniProtKB/TrEMBL
    Q3UR91
    Related
    ENSMUSP00000106752.3, ENSMUST00000111123.9
    Conserved Domains (1) summary
    cd07920
    Location:7211042
    Pumilio; Pumilio-family RNA binding domain
  4. NM_001160222.1NP_001153694.1  pumilio homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_001153694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, is missing an in-frame coding exon, and uses an alternate in-frame donor splice site in the 3' coding region compared to variant 1. This results in a shorter isoform (3) compared to isoform 1.
    Source sequence(s)
    AK134185, AK147617, AK163964, BQ828592
    Consensus CDS
    CCDS49026.1
    UniProtKB/Swiss-Prot
    Q80U58
    UniProtKB/TrEMBL
    Q3TQ29
    Related
    ENSMUSP00000137020.2, ENSMUST00000178015.8
    Conserved Domains (1) summary
    cd07920
    Location:642963
    Pumilio; Pumilio-family RNA binding domain
  5. NM_001310519.1NP_001297448.1  pumilio homolog 2 isoform 4

    See identical proteins and their annotated locations for NP_001297448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, uses two alternate in-frame splice sites in the coding region, and is missing an in-frame coding exon compared to variant 1. This results in a shorter isoform (4) compared to isoform 1.
    Source sequence(s)
    AK134185, AK147617, AK163964, BQ828592
    Consensus CDS
    CCDS79105.1
    UniProtKB/TrEMBL
    Q3TQ29
    Related
    ENSMUSP00000020915.4, ENSMUST00000020915.10
    Conserved Domains (1) summary
    cd07920
    Location:637958
    Pumilio; Pumilio-family RNA binding domain
  6. NM_030723.2NP_109648.2  pumilio homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_109648.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC134245, AF315590, AK147617, AY027917, BQ828592
    Consensus CDS
    CCDS25802.1
    UniProtKB/Swiss-Prot
    Q80U58, Q9ERC7
    Related
    ENSMUSP00000128292.2, ENSMUST00000168361.8
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain

RNA

  1. NR_027670.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 1, but the presence of two additional exons in the 5' coding region causes a frame-shift. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK122225, AK147617, BQ828592, CJ124920
    Related
    ENSMUST00000165293.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    8724092..8802583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515279.4XP_006515342.1  pumilio homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006515342.1

    UniProtKB/Swiss-Prot
    Q80U58, Q9ERC7
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  2. XM_006515284.4XP_006515347.1  pumilio homolog 2 isoform X10

    Conserved Domains (1) summary
    cd07920
    Location:642965
    Pumilio; Pumilio-family RNA binding domain
  3. XM_006515285.4XP_006515348.1  pumilio homolog 2 isoform X11

    See identical proteins and their annotated locations for XP_006515348.1

    UniProtKB/Swiss-Prot
    Q80U58
    Related
    ENSMUSP00000132122.2, ENSMUST00000169089.8
    Conserved Domains (1) summary
    cd07920
    Location:642963
    Pumilio; Pumilio-family RNA binding domain
  4. XM_006515280.4XP_006515343.1  pumilio homolog 2 isoform X3

    Conserved Domains (1) summary
    cd07920
    Location:7161039
    Pumilio; Pumilio-family RNA binding domain
  5. XM_017315255.2XP_017170744.1  pumilio homolog 2 isoform X5

    Conserved Domains (1) summary
    cd07920
    Location:7161037
    Pumilio; Pumilio-family RNA binding domain
  6. XM_017315258.2XP_017170747.1  pumilio homolog 2 isoform X13

    UniProtKB/TrEMBL
    Q3TQ29
    Conserved Domains (1) summary
    cd07920
    Location:637958
    Pumilio; Pumilio-family RNA binding domain
  7. XM_017315254.2XP_017170743.1  pumilio homolog 2 isoform X4

    Conserved Domains (1) summary
    cd07920
    Location:7151038
    Pumilio; Pumilio-family RNA binding domain
  8. XM_017315256.2XP_017170745.1  pumilio homolog 2 isoform X6

    Conserved Domains (1) summary
    cd07920
    Location:7151036
    Pumilio; Pumilio-family RNA binding domain
  9. XM_030246997.1XP_030102857.1  pumilio homolog 2 isoform X12

    Conserved Domains (1) summary
    cd07920
    Location:636959
    Pumilio; Pumilio-family RNA binding domain
  10. XM_017315259.2XP_017170748.1  pumilio homolog 2 isoform X14

    Conserved Domains (1) summary
    cd07920
    Location:636957
    Pumilio; Pumilio-family RNA binding domain
  11. XM_036157686.1XP_036013579.1  pumilio homolog 2 isoform X21

  12. XM_030247001.1XP_030102861.1  pumilio homolog 2 isoform X17

    Conserved Domains (1) summary
    cd07920
    Location:581902
    Pumilio; Pumilio-family RNA binding domain
  13. XM_030247000.2XP_030102860.1  pumilio homolog 2 isoform X15

    Conserved Domains (1) summary
    cd07920
    Location:586907
    Pumilio; Pumilio-family RNA binding domain
  14. XM_036157687.1XP_036013580.1  pumilio homolog 2 isoform X22

  15. XM_017315257.3XP_017170746.1  pumilio homolog 2 isoform X9

    Conserved Domains (1) summary
    cd07920
    Location:665986
    Pumilio; Pumilio-family RNA binding domain
  16. XM_030246995.2XP_030102855.1  pumilio homolog 2 isoform X9

    Conserved Domains (1) summary
    cd07920
    Location:665986
    Pumilio; Pumilio-family RNA binding domain
  17. XM_036157684.1XP_036013577.1  pumilio homolog 2 isoform X20

    Conserved Domains (1) summary
    cd07920
    Location:417738
    Pumilio; Pumilio-family RNA binding domain
  18. XM_030246999.2XP_030102859.1  pumilio homolog 2 isoform X16

    Conserved Domains (1) summary
    cd07920
    Location:586909
    Pumilio; Pumilio-family RNA binding domain
  19. XM_006515283.5XP_006515346.1  pumilio homolog 2 isoform X7

    See identical proteins and their annotated locations for XP_006515346.1

    Conserved Domains (1) summary
    cd07920
    Location:665988
    Pumilio; Pumilio-family RNA binding domain
  20. XM_030246994.2XP_030102854.1  pumilio homolog 2 isoform X8

    Conserved Domains (1) summary
    cd07920
    Location:660983
    Pumilio; Pumilio-family RNA binding domain
  21. XM_006515282.5XP_006515345.1  pumilio homolog 2 isoform X7

    See identical proteins and their annotated locations for XP_006515345.1

    Conserved Domains (1) summary
    cd07920
    Location:665988
    Pumilio; Pumilio-family RNA binding domain
  22. XM_030247003.2XP_030102863.1  pumilio homolog 2 isoform X17

    Conserved Domains (1) summary
    cd07920
    Location:581902
    Pumilio; Pumilio-family RNA binding domain
  23. XM_036157682.1XP_036013575.1  pumilio homolog 2 isoform X19

    Conserved Domains (1) summary
    cd07920
    Location:496819
    Pumilio; Pumilio-family RNA binding domain
  24. XM_030247002.2XP_030102862.1  pumilio homolog 2 isoform X18

    Conserved Domains (1) summary
    cd07920
    Location:580903
    Pumilio; Pumilio-family RNA binding domain
  25. XM_036157685.1XP_036013578.1  pumilio homolog 2 isoform X20

    Conserved Domains (1) summary
    cd07920
    Location:417738
    Pumilio; Pumilio-family RNA binding domain
  26. XM_036157683.1XP_036013576.1  pumilio homolog 2 isoform X19

    Conserved Domains (1) summary
    cd07920
    Location:496819
    Pumilio; Pumilio-family RNA binding domain
  27. XM_006515277.2XP_006515340.1  pumilio homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006515340.1

    UniProtKB/Swiss-Prot
    Q80U58, Q9ERC7
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  28. XM_006515278.5XP_006515341.1  pumilio homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006515341.1

    UniProtKB/Swiss-Prot
    Q80U58, Q9ERC7
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  29. XM_036157681.1XP_036013574.1  pumilio homolog 2 isoform X13

    UniProtKB/TrEMBL
    Q3TQ29
    Conserved Domains (1) summary
    cd07920
    Location:637958
    Pumilio; Pumilio-family RNA binding domain
  30. XM_030246996.1XP_030102856.1  pumilio homolog 2 isoform X11

    Conserved Domains (1) summary
    cd07920
    Location:642963
    Pumilio; Pumilio-family RNA binding domain
  31. XM_030246993.2XP_030102853.1  pumilio homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9ERC7
    Conserved Domains (1) summary
    cd07920
    Location:7211044
    Pumilio; Pumilio-family RNA binding domain
  32. XM_036157680.1XP_036013573.1  pumilio homolog 2 isoform X2

    UniProtKB/TrEMBL
    Q3UR91
    Conserved Domains (1) summary
    cd07920
    Location:7211042
    Pumilio; Pumilio-family RNA binding domain