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USP22 ubiquitin specific peptidase 22 [ Homo sapiens (human) ]

Gene ID: 23326, updated on 6-Nov-2022

Summary

Official Symbol
USP22provided by HGNC
Official Full Name
ubiquitin specific peptidase 22provided by HGNC
Primary source
HGNC:HGNC:12621
See related
Ensembl:ENSG00000124422 MIM:612116; AllianceGenome:HGNC:12621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USP3L
Summary
Enables enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent deubiquitinase. Contributes to H4 histone acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 54.0), ovary (RPKM 38.9) and 25 other tissues See more
Orthologs
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Genomic context

See USP22 in Genome Data Viewer
Location:
17p11.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (20999596..21043419, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (20948437..20991854, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (20902909..20946324, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CCDC144NL antisense RNA 1 Neighboring gene ribonuclease H1 pseudogene 1 Neighboring gene uncharacterized LOC124900389 Neighboring gene uncharacterized LOC339260 Neighboring gene SPECC1 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 1563 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:21002173-21002789 and GRCh37_chr17:21002790-21003407

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1063

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to histone H4 acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in embryo development ending in birth or egg hatching NAS
Non-traceable Author Statement
more info
PubMed 
involved_in histone H3 acetylation IC
Inferred by Curator
more info
PubMed 
involved_in histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoubiquitinated histone H2A deubiquitination IC
Inferred by Curator
more info
 
involved_in monoubiquitinated histone H2A deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoubiquitinated histone deubiquitination IC
Inferred by Curator
more info
 
involved_in monoubiquitinated histone deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA repair IC
Inferred by Curator
more info
PubMed 
involved_in regulation of RNA splicing IC
Inferred by Curator
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SAGA complex IC
Inferred by Curator
more info
PubMed 
part_of SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of transcription factor TFTC complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 22
Names
deubiquitinating enzyme 22
ubiquitin specific protease 22
ubiquitin thioesterase 22
ubiquitin thiolesterase 22
ubiquitin-specific processing protease 22
NP_056091.1
XP_005256632.1
XP_047291659.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015276.2NP_056091.1  ubiquitin carboxyl-terminal hydrolase 22

    See identical proteins and their annotated locations for NP_056091.1

    Status: VALIDATED

    Source sequence(s)
    AB028986, AL110213, BX640815
    Consensus CDS
    CCDS42285.1
    UniProtKB/Swiss-Prot
    Q96IW5, Q9UPT9
    Related
    ENSP00000261497.4, ENST00000261497.9
    Conserved Domains (2) summary
    cd02660
    Location:176518
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam02148
    Location:63123
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    20999596..21043419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256575.3XP_005256632.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

    See identical proteins and their annotated locations for XP_005256632.1

    Conserved Domains (2) summary
    cd02660
    Location:71413
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:70412
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. XM_047435703.1XP_047291659.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    20948437..20991854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)