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USP22 ubiquitin specific peptidase 22 [ Homo sapiens (human) ]

Gene ID: 23326, updated on 28-Nov-2021

Summary

Official Symbol
USP22provided by HGNC
Official Full Name
ubiquitin specific peptidase 22provided by HGNC
Primary source
HGNC:HGNC:12621
See related
Ensembl:ENSG00000124422 MIM:612116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USP3L
Expression
Ubiquitous expression in brain (RPKM 54.0), ovary (RPKM 38.9) and 25 other tissues See more
Orthologs
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Genomic context

See USP22 in Genome Data Viewer
Location:
17p11.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (20999596..21043409, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (20902909..20946324, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CCDC144NL antisense RNA 1 Neighboring gene ribonuclease H1 pseudogene 1 Neighboring gene uncharacterized LOC339260 Neighboring gene SPECC1 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 1563 Neighboring gene Sharpr-MPRA regulatory region 5958

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1063

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to H4 histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thiol-dependent deubiquitinase IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to thiol-dependent deubiquitinase IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 22
Names
deubiquitinating enzyme 22
ubiquitin specific protease 22
ubiquitin thioesterase 22
ubiquitin thiolesterase 22
ubiquitin-specific processing protease 22
NP_056091.1
XP_005256632.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015276.2NP_056091.1  ubiquitin carboxyl-terminal hydrolase 22

    See identical proteins and their annotated locations for NP_056091.1

    Status: VALIDATED

    Source sequence(s)
    AB028986, AL110213, BX640815
    Consensus CDS
    CCDS42285.1
    UniProtKB/Swiss-Prot
    Q9UPT9
    Related
    ENSP00000261497.4, ENST00000261497.9
    Conserved Domains (2) summary
    cd02660
    Location:176518
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam02148
    Location:63123
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    20999596..21043409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256575.2XP_005256632.1  ubiquitin carboxyl-terminal hydrolase 22 isoform X1

    See identical proteins and their annotated locations for XP_005256632.1

    Conserved Domains (2) summary
    cd02660
    Location:71413
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:70412
    UCH; Ubiquitin carboxyl-terminal hydrolase
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