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Usp22 ubiquitin specific peptidase 22 [ Mus musculus (house mouse) ]

Gene ID: 216825, updated on 2-Apr-2024

Summary

Official Symbol
Usp22provided by MGI
Official Full Name
ubiquitin specific peptidase 22provided by MGI
Primary source
MGI:MGI:2144157
See related
Ensembl:ENSMUSG00000042506 AllianceGenome:MGI:2144157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables thiol-dependent deubiquitinase. Acts upstream of or within protein deubiquitination. Predicted to be located in nucleus. Predicted to be part of SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human USP22 (ubiquitin specific peptidase 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 112.1), whole brain E14.5 (RPKM 101.1) and 27 other tissues See more
Orthologs
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Genomic context

See Usp22 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61042607..61065885, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61151781..61175059, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 12 Neighboring gene STARR-positive B cell enhancer ABC_E8878 Neighboring gene STARR-positive B cell enhancer ABC_E5234 Neighboring gene STARR-positive B cell enhancer ABC_E8412 Neighboring gene tumor necrosis factor receptor superfamily, member 13b Neighboring gene STARR-positive B cell enhancer ABC_E3956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:60973670-60973823 Neighboring gene STARR-positive B cell enhancer ABC_E374 Neighboring gene STARR-seq mESC enhancer starr_29671 Neighboring gene predicted gene, 42080 Neighboring gene ribosomal protein S13, pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1063, MGC91200

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H2A deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H2B deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 22
Names
deubiquitinating enzyme 22
ubiquitin specific protease 22
ubiquitin thioesterase 22
ubiquitin thiolesterase 22
ubiquitin-specific-processing protease 22
NP_001004143.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004143.4NP_001004143.2  ubiquitin carboxyl-terminal hydrolase 22

    See identical proteins and their annotated locations for NP_001004143.2

    Status: VALIDATED

    Source sequence(s)
    AK160992, AL646093
    Consensus CDS
    CCDS24807.1
    UniProtKB/Swiss-Prot
    Q3TU34, Q3U2W4, Q5DU02, Q5SU81, Q66JV8, Q6PDX3, Q8BJG3
    Related
    ENSMUSP00000041263.9, ENSMUST00000041683.9
    Conserved Domains (2) summary
    cd02660
    Location:176518
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam02148
    Location:63123
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61042607..61065885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)