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TRIM2 tripartite motif containing 2 [ Homo sapiens (human) ]

Gene ID: 23321, updated on 28-Oct-2018

Summary

Official Symbol
TRIM2provided by HGNC
Official Full Name
tripartite motif containing 2provided by HGNC
Primary source
HGNC:HGNC:15974
See related
Ensembl:ENSG00000109654 MIM:614141; Vega:OTTHUMG00000155991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMT2R; RNF86
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Broad expression in brain (RPKM 37.2), thyroid (RPKM 33.2) and 18 other tissues See more
Orthologs

Genomic context

See TRIM2 in Genome Data Viewer
Location:
4q31.3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (153152281..153339322)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154073650..154260474)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC729870 Neighboring gene family with sequence similarity 192, member A pseudogene Neighboring gene FH2 domain containing 1 Neighboring gene uncharacterized LOC105377496 Neighboring gene RNA, U6 small nuclear 1196, pseudogene Neighboring gene annexin A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene meiotic nuclear divisions 1 Neighboring gene transmembrane 131 like Neighboring gene uncharacterized LOC105377498

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Charcot-Marie-Tooth disease, axonal, type 2R
MedGen: C3809655 OMIM: 615490 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of severity in multiple sclerosis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of tripartite motif containing 2 (TRIM2) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tripartite motif-containing protein 2
Names
E3 ubiquitin-protein ligase TRIM2
RING finger protein 86
RING-type E3 ubiquitin transferase TRIM2
tripartite motif protein TRIM2
NP_001123539.1
NP_001289621.1
NP_001289622.1
NP_001289623.1
NP_001337983.1
NP_001337984.1
NP_001337985.1
NP_001337986.1
NP_056086.2
XP_006714220.1
XP_006714221.1
XP_006714223.1
XP_006714224.1
XP_006714225.1
XP_006714228.1
XP_011530097.1
XP_011530098.1
XP_016863432.1
XP_016863433.1
XP_016863434.1
XP_016863435.1
XP_016863436.1
XP_016863437.1
XP_016863438.1
XP_016863439.1
XP_016863440.1
XP_016863441.1
XP_016863442.1
XP_016863444.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041788.1 RefSeqGene

    Range
    5001..191205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130067.1NP_001123539.1  tripartite motif-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001123539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an alternate splice site, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AB011089, AL110178, BC011052
    Consensus CDS
    CCDS47147.1
    UniProtKB/Swiss-Prot
    Q9C040
    Related
    ENSP00000415812.2, OTTHUMP00000209037, ENST00000437508.6, OTTHUMT00000342652
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  2. NM_001302692.1NP_001289621.1  tripartite motif-containing protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AW071795, BC025417, CF529079, DA631098
    Conserved Domains (1) summary
    cd00162
    Location:5093
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. NM_001302693.1NP_001289622.1  tripartite motif-containing protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site and lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC025417, CF529079, DA407606, DA631098
    Conserved Domains (1) summary
    cd00162
    Location:4992
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  4. NM_001302694.1NP_001289623.1  tripartite motif-containing protein 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains alternate 5' and 3' terminal exons and lacks several other 3' exons, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (5) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    BC025417, BP310511, CF529079, DA310963
    Conserved Domains (1) summary
    cd00162
    Location:4184
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  5. NM_001351054.1NP_001337983.1  tripartite motif-containing protein 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Conserved Domains (6) summary
    smart00502
    Location:179305
    BBC; B-Box C-terminal domain
    smart00336
    Location:131172
    BBOX; B-Box-type zinc finger
    smart00557
    Location:343439
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:489766
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:3883
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:24127
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  6. NM_001351055.1NP_001337984.1  tripartite motif-containing protein 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Conserved Domains (6) summary
    smart00502
    Location:178304
    BBC; B-Box C-terminal domain
    smart00336
    Location:130171
    BBOX; B-Box-type zinc finger
    smart00557
    Location:342438
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:488765
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:3782
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:23126
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  7. NM_001351056.1NP_001337985.1  tripartite motif-containing protein 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  8. NM_001351057.1NP_001337986.1  tripartite motif-containing protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Conserved Domains (4) summary
    smart00502
    Location:36162
    BBC; B-Box C-terminal domain
    smart00336
    Location:129
    BBOX; B-Box-type zinc finger
    smart00557
    Location:200296
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:346619
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
  9. NM_015271.4NP_056086.2  tripartite motif-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_056086.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF220018, AL110178, BC011052, DA631098
    Consensus CDS
    CCDS3781.2
    UniProtKB/Swiss-Prot
    Q9C040
    Related
    ENSP00000339659.5, OTTHUMP00000209036, ENST00000338700.9, OTTHUMT00000342649
    Conserved Domains (7) summary
    smart00502
    Location:188314
    BBC; B-Box C-terminal domain
    smart00336
    Location:140181
    BBOX; B-Box-type zinc finger
    smart00557
    Location:352448
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:562762
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:5093
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:498771
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:352445
    Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    153152281..153339322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007952.1XP_016863441.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  2. XM_017007951.1XP_016863440.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  3. XM_017007948.2XP_016863437.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  4. XM_011531796.3XP_011530098.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011530098.1

    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  5. XM_006714157.1XP_006714220.1  tripartite motif-containing protein 2 isoform X1

    Conserved Domains (8) summary
    smart00502
    Location:188314
    BBC; B-Box C-terminal domain
    smart00336
    Location:140181
    BBOX; B-Box-type zinc finger
    smart00557
    Location:352448
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:562766
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:5093
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:498775
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:352445
    Filamin; Filamin/ABP280 repeat
    sd00039
    Location:519554
    7WD40; WD40 repeat [structural motif]
  6. XM_006714160.1XP_006714223.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006714223.1

    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  7. XM_017007944.1XP_016863433.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  8. XM_006714161.1XP_006714224.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006714224.1

    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  9. XM_017007945.1XP_016863434.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  10. XM_011531795.1XP_011530097.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011530097.1

    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  11. XM_017007950.1XP_016863439.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  12. XM_006714162.1XP_006714225.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006714225.1

    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  13. XM_017007949.1XP_016863438.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00336
    Location:113154
    BBOX; B-Box-type zinc finger
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  14. XM_006714158.1XP_006714221.1  tripartite motif-containing protein 2 isoform X2

    Conserved Domains (8) summary
    smart00502
    Location:187313
    BBC; B-Box C-terminal domain
    smart00336
    Location:139180
    BBOX; B-Box-type zinc finger
    smart00557
    Location:351447
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:561765
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:4992
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:497774
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:351444
    Filamin; Filamin/ABP280 repeat
    sd00039
    Location:518553
    7WD40; WD40 repeat [structural motif]
  15. XM_017007943.1XP_016863432.1  tripartite motif-containing protein 2 isoform X3

    Conserved Domains (7) summary
    smart00502
    Location:187313
    BBC; B-Box C-terminal domain
    smart00336
    Location:139180
    BBOX; B-Box-type zinc finger
    smart00557
    Location:351447
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:561761
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:4992
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:497770
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:351444
    Filamin; Filamin/ABP280 repeat
  16. XM_017007955.1XP_016863444.1  tripartite motif-containing protein 2 isoform X9

    Conserved Domains (4) summary
    smart00502
    Location:36162
    BBC; B-Box C-terminal domain
    smart00336
    Location:129
    BBOX; B-Box-type zinc finger
    smart00557
    Location:200296
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:346619
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
  17. XM_017007946.2XP_016863435.1  tripartite motif-containing protein 2 isoform X6

  18. XM_017007947.1XP_016863436.1  tripartite motif-containing protein 2 isoform X7

  19. XM_017007953.2XP_016863442.1  tripartite motif-containing protein 2 isoform X8

    Conserved Domains (7) summary
    smart00502
    Location:36162
    BBC; B-Box C-terminal domain
    smart00336
    Location:129
    BBOX; B-Box-type zinc finger
    smart00557
    Location:200296
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:410614
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd14960
    Location:346623
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:200293
    Filamin; Filamin/ABP280 repeat
    sd00039
    Location:367402
    7WD40; WD40 repeat [structural motif]
  20. XM_006714165.3XP_006714228.1  tripartite motif-containing protein 2 isoform X8

    See identical proteins and their annotated locations for XP_006714228.1

    Conserved Domains (7) summary
    smart00502
    Location:36162
    BBC; B-Box C-terminal domain
    smart00336
    Location:129
    BBOX; B-Box-type zinc finger
    smart00557
    Location:200296
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:410614
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd14960
    Location:346623
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:200293
    Filamin; Filamin/ABP280 repeat
    sd00039
    Location:367402
    7WD40; WD40 repeat [structural motif]
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