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TRIM2 tripartite motif containing 2 [ Homo sapiens (human) ]

Gene ID: 23321, updated on 24-Nov-2020

Summary

Official Symbol
TRIM2provided by HGNC
Official Full Name
tripartite motif containing 2provided by HGNC
Primary source
HGNC:HGNC:15974
See related
Ensembl:ENSG00000109654 MIM:614141
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMT2R; RNF86
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Broad expression in brain (RPKM 37.2), thyroid (RPKM 33.2) and 18 other tissues See more
Orthologs

Genomic context

See TRIM2 in Genome Data Viewer
Location:
4q31.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (153152163..153339317)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154073650..154260474)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC729870 Neighboring gene family with sequence similarity 192, member A pseudogene Neighboring gene FH2 domain containing 1 Neighboring gene uncharacterized LOC105377496 Neighboring gene RNA, U6 small nuclear 1196, pseudogene Neighboring gene annexin A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene meiotic nuclear divisions 1 Neighboring gene transmembrane 131 like Neighboring gene uncharacterized LOC105377498

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Charcot-Marie-Tooth disease, axonal, type 2R
MedGen: C3809655 OMIM: 615490 GeneReviews: Not available
Compare labs
Genome-wide association study of severity in multiple sclerosis.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of tripartite motif containing 2 (TRIM2) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tripartite motif-containing protein 2
Names
E3 ubiquitin-protein ligase TRIM2
RING finger protein 86
RING-type E3 ubiquitin transferase TRIM2
tripartite motif protein TRIM2
NP_001123539.1
NP_001289621.1
NP_001289622.1
NP_001289623.1
NP_001337983.1
NP_001337984.1
NP_001337985.1
NP_001337986.1
NP_001362417.1
NP_001362418.1
NP_001362419.1
NP_001362420.1
NP_001362441.1
NP_001362442.1
NP_001362443.1
NP_001362444.1
NP_001362445.1
NP_001362446.1
NP_001362448.1
NP_001362449.1
NP_001362451.1
NP_001362452.1
NP_001362454.1
NP_056086.2
XP_006714220.1
XP_006714221.1
XP_006714223.1
XP_006714224.1
XP_006714225.1
XP_006714228.1
XP_011530097.1
XP_011530098.1
XP_016863432.1
XP_016863433.1
XP_016863435.1
XP_016863436.1
XP_016863437.1
XP_016863438.1
XP_016863439.1
XP_016863442.1
XP_016863444.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041788.1 RefSeqGene

    Range
    4961..191200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130067.2NP_001123539.1  tripartite motif-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001123539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an alternate splice site, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AB011089, AC114791, AL110178, BC011052
    Consensus CDS
    CCDS47147.1
    UniProtKB/Swiss-Prot
    Q9C040
    Related
    ENSP00000415812.2, ENST00000437508.6
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  2. NM_001302692.2NP_001289621.1  tripartite motif-containing protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AW071795, BC025417, DA631098
    Conserved Domains (1) summary
    cd00162
    Location:5093
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. NM_001302693.2NP_001289622.1  tripartite motif-containing protein 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site and lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC025417, DA407606, DA631098
    Conserved Domains (1) summary
    cd00162
    Location:4992
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  4. NM_001302694.2NP_001289623.1  tripartite motif-containing protein 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains alternate 5' and 3' terminal exons and lacks several other 3' exons, and it thus differs in both UTRs and in the 5' and 3' coding regions, compared to variant 1. The encoded isoform (5) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    BC025417, DA310963
    Related
    ENSP00000487750.2, ENST00000482578.3
    Conserved Domains (1) summary
    cd00162
    Location:4184
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  5. NM_001351054.2NP_001337983.1  tripartite motif-containing protein 2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Related
    ENSP00000501672.1, ENST00000674935.1
    Conserved Domains (6) summary
    smart00502
    Location:179305
    BBC; B-Box C-terminal domain
    smart00557
    Location:343439
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:24127
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:489766
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:3883
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:133174
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  6. NM_001351055.2NP_001337984.1  tripartite motif-containing protein 2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Related
    ENSP00000502266.1, ENST00000674726.1
    Conserved Domains (6) summary
    smart00502
    Location:178304
    BBC; B-Box C-terminal domain
    smart00336
    Location:130171
    BBOX; B-Box-type zinc finger
    smart00557
    Location:342438
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:488765
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:3782
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl28410
    Location:23126
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
  7. NM_001351056.2NP_001337985.1  tripartite motif-containing protein 2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Related
    ENSP00000502077.1, ENST00000676408.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  8. NM_001351057.2NP_001337986.1  tripartite motif-containing protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791, AI695362
    Conserved Domains (4) summary
    smart00502
    Location:36162
    BBC; B-Box C-terminal domain
    smart00336
    Location:129
    BBOX; B-Box-type zinc finger
    smart00557
    Location:200296
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:346619
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
  9. NM_001375488.1NP_001362417.1  tripartite motif-containing protein 2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000502083.1, ENST00000675673.1
    Conserved Domains (6) summary
    smart00502
    Location:219345
    BBC; B-Box C-terminal domain
    smart00557
    Location:383479
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:33136
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:529802
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:4792
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl00034
    Location:142214
    Bbox_SF; B-box-type zinc finger superfamily
  10. NM_001375489.1NP_001362418.1  tripartite motif-containing protein 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000501562.1, ENST00000675063.1
    Conserved Domains (6) summary
    smart00502
    Location:218344
    BBC; B-Box C-terminal domain
    smart00557
    Location:382478
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:32135
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:528801
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:4691
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cl00034
    Location:141213
    Bbox_SF; B-box-type zinc finger superfamily
  11. NM_001375490.1NP_001362419.1  tripartite motif-containing protein 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000502541.1, ENST00000675780.1
    Conserved Domains (6) summary
    smart00502
    Location:188295
    BBC; B-Box C-terminal domain
    smart00557
    Location:333429
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:33136
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:479752
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:4792
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:142183
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  12. NM_001375491.1NP_001362420.1  tripartite motif-containing protein 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000502290.1, ENST00000675340.1
    Conserved Domains (6) summary
    smart00502
    Location:187294
    BBC; B-Box C-terminal domain
    smart00557
    Location:332428
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:32135
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:478751
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:4691
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:141182
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  13. NM_001375512.1NP_001362441.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000502356.1, ENST00000674976.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  14. NM_001375513.1NP_001362442.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000502676.1, ENST00000675315.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  15. NM_001375514.1NP_001362443.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000501662.1, ENST00000675745.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  16. NM_001375515.1NP_001362444.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000501994.1, ENST00000676458.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  17. NM_001375516.1NP_001362445.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000502543.1, ENST00000675054.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  18. NM_001375517.1NP_001362446.1  tripartite motif-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000501612.1, ENST00000676423.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  19. NM_001375519.1NP_001362448.1  tripartite motif-containing protein 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000502492.1, ENST00000675425.1
    Conserved Domains (4) summary
    smart00502
    Location:112203
    BBC; B-Box C-terminal domain
    smart00557
    Location:241337
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:387660
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:4792
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
  20. NM_001375520.1NP_001362449.1  tripartite motif-containing protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000502720.1, ENST00000675492.1
    Conserved Domains (4) summary
    smart00502
    Location:111202
    BBC; B-Box C-terminal domain
    smart00557
    Location:240336
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:386659
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:4691
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
  21. NM_001375522.1NP_001362451.1  tripartite motif-containing protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000501997.1, ENST00000675710.1
    Conserved Domains (4) summary
    smart00502
    Location:75201
    BBC; B-Box C-terminal domain
    smart00557
    Location:239335
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:385658
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd19824
    Location:2970
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  22. NM_001375523.1NP_001362452.1  tripartite motif-containing protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Conserved Domains (4) summary
    smart00502
    Location:75201
    BBC; B-Box C-terminal domain
    smart00557
    Location:239335
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:385658
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd19824
    Location:2970
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  23. NM_001375525.1NP_001362454.1  tripartite motif-containing protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC013477, AC114791
    Related
    ENSP00000502776.1, ENST00000675782.1
    Conserved Domains (4) summary
    smart00502
    Location:75201
    BBC; B-Box C-terminal domain
    smart00557
    Location:239335
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:385658
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd19824
    Location:2970
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  24. NM_015271.5NP_056086.2  tripartite motif-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_056086.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF220018, AL110178, BC011052, DA631098
    Consensus CDS
    CCDS3781.2
    UniProtKB/Swiss-Prot
    Q9C040
    Related
    ENSP00000339659.5, ENST00000338700.10
    Conserved Domains (7) summary
    smart00502
    Location:188314
    BBC; B-Box C-terminal domain
    smart00336
    Location:140181
    BBOX; B-Box-type zinc finger
    smart00557
    Location:352448
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:562762
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:5093
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:498771
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:352445
    Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    153152163..153339317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007948.2XP_016863437.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Related
    ENSP00000502519.1, ENST00000674874.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  2. XM_011531796.3XP_011530098.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011530098.1

    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  3. XM_006714157.1XP_006714220.1  tripartite motif-containing protein 2 isoform X1

    Conserved Domains (8) summary
    smart00502
    Location:188314
    BBC; B-Box C-terminal domain
    smart00336
    Location:140181
    BBOX; B-Box-type zinc finger
    smart00557
    Location:352448
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:562766
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:5093
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:498775
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:352445
    Filamin; Filamin/ABP280 repeat
    sd00039
    Location:519554
    7WD40; WD40 repeat [structural motif]
  4. XM_006714160.1XP_006714223.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006714223.1

    Related
    ENSP00000502775.1, ENST00000675899.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  5. XM_017007944.1XP_016863433.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Related
    ENSP00000502114.1, ENST00000675384.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  6. XM_006714161.1XP_006714224.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006714224.1

    Related
    ENSP00000502331.1, ENST00000676167.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  7. XM_011531795.1XP_011530097.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011530097.1

    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  8. XM_017007950.1XP_016863439.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Related
    ENSP00000501951.1, ENST00000675835.1
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  9. XM_006714162.1XP_006714225.1  tripartite motif-containing protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006714225.1

    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471748
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  10. XM_017007949.1XP_016863438.1  tripartite motif-containing protein 2 isoform X5

    UniProtKB/Swiss-Prot
    Q9C040
    Conserved Domains (6) summary
    smart00502
    Location:161287
    BBC; B-Box C-terminal domain
    smart00557
    Location:325421
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:6109
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:2065
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:115156
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  11. XM_006714158.1XP_006714221.1  tripartite motif-containing protein 2 isoform X2

    Related
    ENST00000675363.1
    Conserved Domains (8) summary
    smart00502
    Location:187313
    BBC; B-Box C-terminal domain
    smart00336
    Location:139180
    BBOX; B-Box-type zinc finger
    smart00557
    Location:351447
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:561765
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:4992
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:497774
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:351444
    Filamin; Filamin/ABP280 repeat
    sd00039
    Location:518553
    7WD40; WD40 repeat [structural motif]
  12. XM_017007943.1XP_016863432.1  tripartite motif-containing protein 2 isoform X3

    Conserved Domains (7) summary
    smart00502
    Location:187313
    BBC; B-Box C-terminal domain
    smart00336
    Location:139180
    BBOX; B-Box-type zinc finger
    smart00557
    Location:351447
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:561761
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00162
    Location:4992
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14960
    Location:497770
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:351444
    Filamin; Filamin/ABP280 repeat
  13. XM_017007955.1XP_016863444.1  tripartite motif-containing protein 2 isoform X9

    Conserved Domains (4) summary
    smart00502
    Location:36162
    BBC; B-Box C-terminal domain
    smart00336
    Location:129
    BBOX; B-Box-type zinc finger
    smart00557
    Location:200296
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:346619
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
  14. XM_017007946.2XP_016863435.1  tripartite motif-containing protein 2 isoform X6

    Related
    ENSP00000501671.1, ENST00000675977.1
    Conserved Domains (6) summary
    smart00502
    Location:179305
    BBC; B-Box C-terminal domain
    smart00557
    Location:343439
    IG_FLMN; Filamin-type immunoglobulin domains
    COG5432
    Location:24127
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd14960
    Location:489762
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16767
    Location:3883
    RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)
    cd19824
    Location:133174
    Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
  15. XM_017007947.1XP_016863436.1  tripartite motif-containing protein 2 isoform X7

    Related
    ENSP00000501725.1, ENST00000674896.1
  16. XM_017007953.2XP_016863442.1  tripartite motif-containing protein 2 isoform X8

    Conserved Domains (7) summary
    smart00502
    Location:36162
    BBC; B-Box C-terminal domain
    smart00336
    Location:129
    BBOX; B-Box-type zinc finger
    smart00557
    Location:200296
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:410614
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd14960
    Location:346623
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:200293
    Filamin; Filamin/ABP280 repeat
    sd00039
    Location:367402
    7WD40; WD40 repeat [structural motif]
  17. XM_006714165.3XP_006714228.1  tripartite motif-containing protein 2 isoform X8

    See identical proteins and their annotated locations for XP_006714228.1

    Conserved Domains (7) summary
    smart00502
    Location:36162
    BBC; B-Box C-terminal domain
    smart00336
    Location:129
    BBOX; B-Box-type zinc finger
    smart00557
    Location:200296
    IG_FLMN; Filamin-type immunoglobulin domains
    COG3391
    Location:410614
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd14960
    Location:346623
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    pfam00630
    Location:200293
    Filamin; Filamin/ABP280 repeat
    sd00039
    Location:367402
    7WD40; WD40 repeat [structural motif]
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