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Mybpc2 myosin binding protein C, fast-type [ Mus musculus (house mouse) ]

Gene ID: 233199, updated on 5-Mar-2024

Summary

Official Symbol
Mybpc2provided by MGI
Official Full Name
myosin binding protein C, fast-typeprovided by MGI
Primary source
MGI:MGI:1336170
See related
Ensembl:ENSMUSG00000038670 AllianceGenome:MGI:1336170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within muscle contraction. Predicted to be located in cytoskeleton. Is expressed in diaphragm; extensor digitorum longus; hindlimb; rectus femoris; and soleus. Orthologous to human MYBPC2 (myosin binding protein C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 39.2) and heart adult (RPKM 2.0) See more
Orthologs
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Genomic context

See Mybpc2 in Genome Data Viewer
Location:
7 B3; 7 28.83 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44151123..44174093, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44501699..44524715, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5430431A17 gene Neighboring gene STARR-seq mESC enhancer starr_18800 Neighboring gene ER membrane protein complex subunit 10 Neighboring gene golgi associated RAB2 interactor 5A Neighboring gene STARR-positive B cell enhancer ABC_E10437 Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC28149

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscle contraction TAS
Traceable Author Statement
more info
PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
myosin-binding protein C, fast-type
Names
fast MyBP-C
fast-type C-protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146189.3NP_666301.2  myosin-binding protein C, fast-type

    See identical proteins and their annotated locations for NP_666301.2

    Status: VALIDATED

    Source sequence(s)
    AK029282, AK132563, CK787764
    Consensus CDS
    CCDS52233.1
    UniProtKB/Swiss-Prot
    Q5XKE0, Q8C109, Q8K2V0
    Related
    ENSMUSP00000130127.3, ENSMUST00000165208.4
    Conserved Domains (7) summary
    cd00096
    Location:10621127
    Ig; Immunoglobulin domain
    cd05748
    Location:853924
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd05894
    Location:545630
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:548630
    IG_like; Immunoglobulin like
    cd00063
    Location:634720
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:10431132
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:278325
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44151123..44174093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)