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KIF13B kinesin family member 13B [ Homo sapiens (human) ]

Gene ID: 23303, updated on 25-Nov-2021

Summary

Official Symbol
KIF13Bprovided by HGNC
Official Full Name
kinesin family member 13Bprovided by HGNC
Primary source
HGNC:HGNC:14405
See related
Ensembl:ENSG00000197892 MIM:607350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAKIN
Expression
Ubiquitous expression in kidney (RPKM 15.2), colon (RPKM 14.6) and 25 other tissues See more
Orthologs
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Genomic context

See KIF13B in Genome Data Viewer
Location:
8p12
Exon count:
42
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (29067278..29263385, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28924795..29120587, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene homeobox containing 1 Neighboring gene uncharacterized LOC105379346 Neighboring gene RNA, 5S ribosomal pseudogene 260 Neighboring gene high mobility group box 1 pseudogene 23 Neighboring gene Sharpr-MPRA regulatory region 4987 Neighboring gene Sharpr-MPRA regulatory region 3532 Neighboring gene dual specificity phosphatase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available
Genome-wide association of lipid-lowering response to statins in combined study populations.
GeneReviews: Not available
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
GeneReviews: Not available
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0639

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule-based movement TAS
Traceable Author Statement
more info
PubMed 
involved_in protein targeting TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF13B
Names
guanylate kinase associated kinesin
kinesin 13B
kinesin-like protein GAKIN

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015254.4NP_056069.2  kinesin-like protein KIF13B

    See identical proteins and their annotated locations for NP_056069.2

    Status: VALIDATED

    Source sequence(s)
    AB014539, AC108449, AI760125, DA068190, DA437040
    Consensus CDS
    CCDS55217.1
    UniProtKB/Swiss-Prot
    Q9NQT8
    Related
    ENSP00000427900.1, ENST00000524189.6
    Conserved Domains (10) summary
    smart00129
    Location:6360
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:447544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:17041767
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:15391643
    Jun; Jun-like transcription factor
    pfam12423
    Location:756802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12211279
    DUF3694; Kinesin protein
    pfam16183
    Location:357469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10991143
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    29067278..29263385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544459.3XP_011542761.1  kinesin-like protein KIF13B isoform X4

    See identical proteins and their annotated locations for XP_011542761.1

    Conserved Domains (11) summary
    smart00129
    Location:9296
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:395508
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:383480
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:3296
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:16611724
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:14961600
    Jun; Jun-like transcription factor
    pfam12423
    Location:692738
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11571215
    DUF3694; Kinesin protein
    pfam16183
    Location:293405
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:546646
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10351079
    DUF3585; Protein of unknown function (DUF3585)
  2. XM_011544461.1XP_011542763.1  kinesin-like protein KIF13B isoform X4

    See identical proteins and their annotated locations for XP_011542763.1

    Conserved Domains (11) summary
    smart00129
    Location:9296
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:395508
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:383480
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:3296
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:16611724
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:14961600
    Jun; Jun-like transcription factor
    pfam12423
    Location:692738
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11571215
    DUF3694; Kinesin protein
    pfam16183
    Location:293405
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:546646
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10351079
    DUF3585; Protein of unknown function (DUF3585)
  3. XM_005273458.1XP_005273515.1  kinesin-like protein KIF13B isoform X3

    Conserved Domains (11) summary
    smart00129
    Location:6360
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:459572
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:447544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:16831746
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:15181622
    Jun; Jun-like transcription factor
    pfam12423
    Location:756802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12211279
    DUF3694; Kinesin protein
    pfam16183
    Location:357469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10991143
    DUF3585; Protein of unknown function (DUF3585)
  4. XM_011544458.1XP_011542760.1  kinesin-like protein KIF13B isoform X2

    Conserved Domains (10) summary
    smart00129
    Location:6360
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:447544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:17041767
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:15391643
    Jun; Jun-like transcription factor
    pfam12423
    Location:756802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12211279
    DUF3694; Kinesin protein
    pfam16183
    Location:357469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10991143
    DUF3585; Protein of unknown function (DUF3585)
  5. XM_011544457.1XP_011542759.1  kinesin-like protein KIF13B isoform X1

    Conserved Domains (10) summary
    smart00129
    Location:6360
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:447544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:17251788
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:15601664
    Jun; Jun-like transcription factor
    pfam12423
    Location:756802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12211279
    DUF3694; Kinesin protein
    pfam16183
    Location:357469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10991143
    DUF3585; Protein of unknown function (DUF3585)
  6. XM_011544460.3XP_011542762.1  kinesin-like protein KIF13B isoform X4

    See identical proteins and their annotated locations for XP_011542762.1

    Conserved Domains (11) summary
    smart00129
    Location:9296
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:395508
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:383480
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:3296
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:16611724
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:14961600
    Jun; Jun-like transcription factor
    pfam12423
    Location:692738
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11571215
    DUF3694; Kinesin protein
    pfam16183
    Location:293405
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:546646
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10351079
    DUF3585; Protein of unknown function (DUF3585)
  7. XM_017013257.1XP_016868746.1  kinesin-like protein KIF13B isoform X5

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