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KIF13B kinesin family member 13B [ Homo sapiens (human) ]

Gene ID: 23303, updated on 2-Oct-2018

Summary

Official Symbol
KIF13Bprovided by HGNC
Official Full Name
kinesin family member 13Bprovided by HGNC
Primary source
HGNC:HGNC:14405
See related
Ensembl:ENSG00000197892 MIM:607350; Vega:OTTHUMG00000164032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAKIN
Expression
Ubiquitous expression in kidney (RPKM 15.2), colon (RPKM 14.6) and 25 other tissues See more
Orthologs

Genomic context

See KIF13B in Genome Data Viewer
Location:
8p12
Exon count:
42
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (29067278..29263385, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28924795..29120610, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene homeobox containing 1 Neighboring gene uncharacterized LOC105379346 Neighboring gene RNA, 5S ribosomal pseudogene 260 Neighboring gene high mobility group box 1 pseudogene 23 Neighboring gene uncharacterized LOC105379349 Neighboring gene dual specificity phosphatase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
NHGRI GWA Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog

Pathways from BioSystems

  • Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 signaling events, organism-specific biosystem
    Arf6 signaling events
  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0639

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell activation NAS
Non-traceable Author Statement
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based movement TAS
Traceable Author Statement
more info
PubMed 
protein targeting TAS
Traceable Author Statement
more info
PubMed 
regulation of axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microvillus IEA
Inferred from Electronic Annotation
more info
 
paranode region of axon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin-like protein KIF13B
Names
guanylate kinase associated kinesin
kinesin 13B
kinesin-like protein GAKIN

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015254.3NP_056069.2  kinesin-like protein KIF13B

    See identical proteins and their annotated locations for NP_056069.2

    Status: VALIDATED

    Source sequence(s)
    AB014539, AC108449, AI760125, DA068190, DA437040
    Consensus CDS
    CCDS55217.1
    UniProtKB/Swiss-Prot
    Q9NQT8
    Related
    ENSP00000427900.1, OTTHUMP00000225649, ENST00000524189.5, OTTHUMT00000376878
    Conserved Domains (10) summary
    smart00129
    Location:6360
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:447544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:17041767
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:15391643
    Jun; Jun-like transcription factor
    pfam12423
    Location:756802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12211279
    DUF3694; Kinesin protein
    pfam16183
    Location:357469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10991143
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    29067278..29263385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544459.3XP_011542761.1  kinesin-like protein KIF13B isoform X4

    See identical proteins and their annotated locations for XP_011542761.1

    Conserved Domains (11) summary
    smart00129
    Location:9296
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:395508
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:383480
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:3296
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:16611724
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:14961600
    Jun; Jun-like transcription factor
    pfam12423
    Location:692738
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11571215
    DUF3694; Kinesin protein
    pfam16183
    Location:293405
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:546646
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10351079
    DUF3585; Protein of unknown function (DUF3585)
  2. XM_011544461.1XP_011542763.1  kinesin-like protein KIF13B isoform X4

    See identical proteins and their annotated locations for XP_011542763.1

    Conserved Domains (11) summary
    smart00129
    Location:9296
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:395508
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:383480
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:3296
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:16611724
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:14961600
    Jun; Jun-like transcription factor
    pfam12423
    Location:692738
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11571215
    DUF3694; Kinesin protein
    pfam16183
    Location:293405
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:546646
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10351079
    DUF3585; Protein of unknown function (DUF3585)
  3. XM_005273458.1XP_005273515.1  kinesin-like protein KIF13B isoform X3

    Conserved Domains (11) summary
    smart00129
    Location:6360
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:459572
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:447544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:16831746
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:15181622
    Jun; Jun-like transcription factor
    pfam12423
    Location:756802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12211279
    DUF3694; Kinesin protein
    pfam16183
    Location:357469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10991143
    DUF3585; Protein of unknown function (DUF3585)
  4. XM_011544458.1XP_011542760.1  kinesin-like protein KIF13B isoform X2

    Conserved Domains (10) summary
    smart00129
    Location:6360
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:447544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:17041767
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:15391643
    Jun; Jun-like transcription factor
    pfam12423
    Location:756802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12211279
    DUF3694; Kinesin protein
    pfam16183
    Location:357469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10991143
    DUF3585; Protein of unknown function (DUF3585)
  5. XM_011544457.1XP_011542759.1  kinesin-like protein KIF13B isoform X1

    Conserved Domains (10) summary
    smart00129
    Location:6360
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:447544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:17251788
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:15601664
    Jun; Jun-like transcription factor
    pfam12423
    Location:756802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:12211279
    DUF3694; Kinesin protein
    pfam16183
    Location:357469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10991143
    DUF3585; Protein of unknown function (DUF3585)
  6. XM_011544460.3XP_011542762.1  kinesin-like protein KIF13B isoform X4

    See identical proteins and their annotated locations for XP_011542762.1

    Conserved Domains (11) summary
    smart00129
    Location:9296
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:395508
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:383480
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:3296
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:16611724
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:14961600
    Jun; Jun-like transcription factor
    pfam12423
    Location:692738
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:11571215
    DUF3694; Kinesin protein
    pfam16183
    Location:293405
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:546646
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:10351079
    DUF3585; Protein of unknown function (DUF3585)
  7. XM_017013257.1XP_016868746.1  kinesin-like protein KIF13B isoform X5

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