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BOP1 BOP1 ribosomal biogenesis factor [ Homo sapiens (human) ]

Gene ID: 23246, updated on 3-May-2020

Summary

Official Symbol
BOP1provided by HGNC
Official Full Name
BOP1 ribosomal biogenesis factorprovided by HGNC
Primary source
HGNC:HGNC:15519
See related
Ensembl:ENSG00000261236 MIM:610596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 10.2), appendix (RPKM 9.2) and 25 other tissues See more
Orthologs

Genomic context

See BOP1 in Genome Data Viewer
Location:
8q24.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144262045..144291438, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145486056..145515120, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene testis specific serine kinase 5, pseudogene Neighboring gene maestro heat like repeat family member 1 Neighboring gene microRNA 7112 Neighboring gene scleraxis bHLH transcription factor Neighboring gene heat shock transcription factor 1 Neighboring gene microRNA 6848 Neighboring gene diacylglycerol O-acyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of block of proliferation 1 (BOP1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0124

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
PeBoW complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PeBoW complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribosome biogenesis protein BOP1
Names
block of proliferation 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015201.5NP_056016.1  ribosome biogenesis protein BOP1

    See identical proteins and their annotated locations for NP_056016.1

    Status: VALIDATED

    Source sequence(s)
    AC145291, AI937005, BC013787, BQ711345, DA510177
    Consensus CDS
    CCDS6418.2
    UniProtKB/Swiss-Prot
    Q14137
    Related
    ENSP00000455106.1, ENST00000569669.6
    Conserved Domains (4) summary
    COG2319
    Location:409745
    WD40; WD40 repeat [General function prediction only]
    pfam08145
    Location:144402
    BOP1NT; BOP1NT (NUC169) domain
    sd00039
    Location:417453
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:408745
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144262045..144291438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654716.1 Reference GRCh38.p13 PATCHES

    Range
    6826..22041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_027499.1: Suppressed sequence

    Description
    NG_027499.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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