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Bop1 block of proliferation 1 [ Mus musculus (house mouse) ]

Gene ID: 12181, updated on 5-May-2024

Summary

Official Symbol
Bop1provided by MGI
Official Full Name
block of proliferation 1provided by MGI
Primary source
MGI:MGI:1334460
See related
Ensembl:ENSMUSG00000022557 AllianceGenome:MGI:1334460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Erb1p; Kiaa0124; mKIAA0124
Summary
Enables ribonucleoprotein complex binding activity. Involved in cell population proliferation and cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Acts upstream of or within rRNA processing and ribosomal large subunit biogenesis. Located in nucleolus. Is expressed in several structures, including female reproductive system and urinary system. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 54.9), thymus adult (RPKM 50.5) and 28 other tissues See more
Orthologs
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Genomic context

See Bop1 in Genome Data Viewer
Location:
15 D3; 15 35.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76337188..76361449, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76452988..76477249, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1912 Neighboring gene testis-specific serine kinase 5 Neighboring gene maestro heat-like repeat family member 1 Neighboring gene microRNA 6954 Neighboring gene scleraxis scleraxis bHLH transcription factor Neighboring gene STARR-positive B cell enhancer ABC_E5490 Neighboring gene heat shock factor 1 Neighboring gene diacylglycerol O-acyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of PeBoW complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of PeBoW complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
ribosome biogenesis protein BOP1
Names
block of proliferation 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013481.2NP_038509.1  ribosome biogenesis protein BOP1

    See identical proteins and their annotated locations for NP_038509.1

    Status: VALIDATED

    Source sequence(s)
    AK079627, AV349722
    Consensus CDS
    CCDS27570.1
    UniProtKB/Swiss-Prot
    P97452, Q3TK87, Q6ZQI9, Q91X31
    UniProtKB/TrEMBL
    Q3TJZ5
    Related
    ENSMUSP00000023217.10, ENSMUST00000023217.11
    Conserved Domains (4) summary
    COG2319
    Location:395732
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:394732
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08145
    Location:130388
    BOP1NT; BOP1NT (NUC169) domain
    sd00039
    Location:403441
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76337188..76361449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159096.1XP_036014989.1  ribosome biogenesis protein BOP1 isoform X1

    Conserved Domains (3) summary
    cd00200
    Location:233571
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:242280
    7WD40; WD40 repeat [structural motif]
    pfam08145
    Location:1227
    BOP1NT; BOP1NT (NUC169) domain