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TMEM131L transmembrane 131 like [ Homo sapiens (human) ]

Gene ID: 23240, updated on 21-Dec-2019

Summary

Official Symbol
TMEM131Lprovided by HGNC
Official Full Name
transmembrane 131 likeprovided by HGNC
Primary source
HGNC:HGNC:29146
See related
Ensembl:ENSG00000121210 MIM:616243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA0922
Expression
Broad expression in lymph node (RPKM 22.3), bone marrow (RPKM 15.4) and 22 other tissues See more
Orthologs

Genomic context

See TMEM131L in Genome Data Viewer
Location:
4q31.3
Exon count:
37
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (153466346..153637608)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154387498..154558760)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 2 Neighboring gene annexin A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene meiotic nuclear divisions 1 Neighboring gene uncharacterized LOC105377498 Neighboring gene toll like receptor 2 pseudogene Neighboring gene WD repeat domain 45 pseudogene 1 Neighboring gene toll like receptor 2 Neighboring gene ring finger protein 175

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of KIAA0922 by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with KIAA0922 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10592, DKFZp586H1322

Gene Ontology Provided by GOA

Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 131-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131007.2NP_001124479.1  transmembrane protein 131-like isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AK092270, AK096538, AK308448, BC044932
    Consensus CDS
    CCDS47148.1
    UniProtKB/Swiss-Prot
    A2VDJ0
    UniProtKB/TrEMBL
    B3KU55
    Related
    ENSP00000386787.3, ENST00000409959.8
    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  2. NM_015196.3NP_056011.3  transmembrane protein 131-like isoform 2 precursor

    See identical proteins and their annotated locations for NP_056011.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    BC131505, BQ270562, DA778851
    Consensus CDS
    CCDS3783.2
    UniProtKB/Swiss-Prot
    A2VDJ0
    Related
    ENSP00000386574.3, ENST00000409663.7
    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    153466346..153637608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453956.1XP_024309724.1  transmembrane protein 131-like isoform X3

    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  2. XM_017007925.1XP_016863414.1  transmembrane protein 131-like isoform X5

  3. XM_024453957.1XP_024309725.1  transmembrane protein 131-like isoform X4

    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  4. XM_017007926.1XP_016863415.1  transmembrane protein 131-like isoform X6

  5. XM_011531780.1XP_011530082.1  transmembrane protein 131-like isoform X1

    Conserved Domains (1) summary
    cl13764
    Location:120203
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  6. XM_011531783.1XP_011530085.1  transmembrane protein 131-like isoform X7

    Related
    ENSP00000240487.5, ENST00000240487.5
    Conserved Domains (1) summary
    cl13764
    Location:120203
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  7. XM_011531781.1XP_011530083.1  transmembrane protein 131-like isoform X2

    Conserved Domains (1) summary
    cl13764
    Location:120203
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  8. XM_024453958.1XP_024309726.1  transmembrane protein 131-like isoform X8

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