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Tmem131l transmembrane 131 like [ Mus musculus (house mouse) ]

Gene ID: 229473, updated on 5-Mar-2024

Summary

Official Symbol
Tmem131lprovided by MGI
Official Full Name
transmembrane 131 likeprovided by MGI
Primary source
MGI:MGI:2443399
See related
Ensembl:ENSMUSG00000033767 AllianceGenome:MGI:2443399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa0922; mKIAA0922; D930015E06Rik
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human TMEM131L (transmembrane 131 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 30.1), whole brain E14.5 (RPKM 27.0) and 28 other tissues See more
Orthologs
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Genomic context

See Tmem131l in Genome Data Viewer
Location:
3 F1; 3 37.42 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (83804955..83947497, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (83898205..84040190, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 175 pseudogene Neighboring gene toll-like receptor 2 Neighboring gene STARR-seq mESC enhancer starr_08062 Neighboring gene STARR-seq mESC enhancer starr_08063 Neighboring gene STARR-seq mESC enhancer starr_08065 Neighboring gene STARR-positive B cell enhancer ABC_E518 Neighboring gene STARR-positive B cell enhancer ABC_E4548 Neighboring gene predicted gene, 30352 Neighboring gene predicted gene, 30458

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transmembrane protein 131-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399526.1NP_001386455.1  transmembrane protein 131-like isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102289, AC133160, AC154875
  2. NM_172681.5NP_766269.3  transmembrane protein 131-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_766269.3

    Status: VALIDATED

    Source sequence(s)
    AC102289, AC133160, AC154875
    Consensus CDS
    CCDS38463.1
    UniProtKB/Swiss-Prot
    Q3U3D7, Q6P5E2, Q6PHM5, Q6ZQ24, Q8C2B9, Q8K2U7, Q8R3Y2, Q8R580
    Related
    ENSMUSP00000141438.2, ENSMUST00000191758.6
    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    83804955..83947497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163039.1XP_036018932.1  transmembrane protein 131-like isoform X7

    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  2. XM_006501326.4XP_006501389.1  transmembrane protein 131-like isoform X5

    UniProtKB/TrEMBL
    A0A0B4J1F5
    Related
    ENSMUSP00000049808.9, ENSMUST00000052342.9
    Conserved Domains (2) summary
    pfam06070
    Location:11701520
    Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  3. XM_036163038.1XP_036018931.1  transmembrane protein 131-like isoform X3

    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  4. XM_006501323.3XP_006501386.1  transmembrane protein 131-like isoform X1

    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  5. XM_006501327.3XP_006501390.1  transmembrane protein 131-like isoform X6

    Related
    ENSMUSP00000141607.2, ENSMUST00000192095.6
    Conserved Domains (2) summary
    pfam06070
    Location:11891520
    Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  6. XM_006501325.2XP_006501388.1  transmembrane protein 131-like isoform X4

    UniProtKB/Swiss-Prot
    Q3U3D7
    Conserved Domains (2) summary
    pfam06070
    Location:11891521
    Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
  7. XM_006501324.3XP_006501387.1  transmembrane protein 131-like isoform X2

    Conserved Domains (1) summary
    cl13764
    Location:91174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin