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RHOBTB2 Rho related BTB domain containing 2 [ Homo sapiens (human) ]

Gene ID: 23221, updated on 3-May-2020

Summary

Official Symbol
RHOBTB2provided by HGNC
Official Full Name
Rho related BTB domain containing 2provided by HGNC
Primary source
HGNC:HGNC:18756
See related
Ensembl:ENSG00000008853 MIM:607352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p83; DBC2; EIEE64
Summary
The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Broad expression in lung (RPKM 11.1), brain (RPKM 8.7) and 22 other tissues See more
Orthologs

Genomic context

See RHOBTB2 in Genome Data Viewer
Location:
8p21.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22987251..23020199)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22844930..22877710)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene VISTA enhancer hs1927 Neighboring gene RNA, 7SL, cytoplasmic 303, pseudogene Neighboring gene TNF receptor superfamily member 10b Neighboring gene TNFRSF10B 5' regulatory region Neighboring gene Sharpr-MPRA regulatory region 12406 Neighboring gene TNF receptor superfamily member 10d pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0717

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho-related BTB domain-containing protein 2
Names
deleted in breast cancer 2 gene protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047133.1 RefSeqGene

    Range
    4994..37942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160036.2NP_001153508.1  rho-related BTB domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001153508.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA641575, AB018260, AC107959, AK292863, AY009093, BC034917, BG255120
    Consensus CDS
    CCDS55210.1
    UniProtKB/Swiss-Prot
    Q9BYZ6
    Related
    ENSP00000427926.1, ENST00000519685.5
    Conserved Domains (5) summary
    cd01873
    Location:35229
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:39230
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:523615
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:513615
    BTB; BTB/POZ domain
    cl02518
    Location:443490
    BTB; BTB/POZ domain
  2. NM_001160037.2NP_001153509.1  rho-related BTB domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC107959
    Consensus CDS
    CCDS55211.1
    UniProtKB/Swiss-Prot
    Q9BYZ6
    Related
    ENSP00000429141.1, ENST00000522948.5
    Conserved Domains (5) summary
    cd01873
    Location:20214
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:24215
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:508600
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:498600
    BTB; BTB/POZ domain
    cl02518
    Location:428475
    BTB; BTB/POZ domain
  3. NM_001374791.1NP_001361720.1  rho-related BTB domain-containing protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC107959
  4. NM_015178.3NP_055993.2  rho-related BTB domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_055993.2

    Status: REVIEWED

    Source sequence(s)
    AC107959
    Consensus CDS
    CCDS6034.1
    UniProtKB/Swiss-Prot
    Q9BYZ6
    Related
    ENSP00000251822.6, ENST00000251822.6
    Conserved Domains (3) summary
    cd01873
    Location:13207
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00225
    Location:501593
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cl02518
    Location:258302
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    22987251..23020199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013251.1XP_016868740.1  rho-related BTB domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9BYZ6
    Conserved Domains (5) summary
    cd01873
    Location:35229
    RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
    smart00174
    Location:39230
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    smart00225
    Location:523615
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:513615
    BTB; BTB/POZ domain
    cl02518
    Location:443490
    BTB; BTB/POZ domain
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