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CLCC1 chloride channel CLIC like 1 [ Homo sapiens (human) ]

Gene ID: 23155, updated on 7-Jun-2020

Summary

Official Symbol
CLCC1provided by HGNC
Official Full Name
chloride channel CLIC like 1provided by HGNC
Primary source
HGNC:HGNC:29675
See related
Ensembl:ENSG00000121940 MIM:617539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCLC
Expression
Ubiquitous expression in brain (RPKM 9.3), thyroid (RPKM 9.3) and 25 other tissues See more
Orthologs

Genomic context

See CLCC1 in Genome Data Viewer
Location:
1p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (108929505..108963484, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (109472130..109506121, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene AKNA domain containing 1 Neighboring gene uncharacterized LOC107985159 Neighboring gene spermatogenesis associated 42 Neighboring gene G protein signaling modulator 2 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 pseudogene Neighboring gene WD repeat domain 47 Neighboring gene ribosomal protein L17 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: AKNAD1

Homology

Clone Names

  • FLJ57956, KIAA0761

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Mitochondria-associated ER Membrane IDA
Inferred from Direct Assay
more info
PubMed 
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chloride channel CLIC-like protein 1
Names
Mid-1-related chloride channel protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048210.3NP_001041675.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001041675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL449266
    Consensus CDS
    CCDS41362.1
    UniProtKB/Swiss-Prot
    Q96S66
    UniProtKB/TrEMBL
    A0A024R0G0
    Conserved Domains (1) summary
    pfam05934
    Location:14551
    MCLC; Mid-1-related chloride channel (MCLC)
  2. NM_001278202.2NP_001265131.1  chloride channel CLIC-like protein 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001265131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL449266
    Consensus CDS
    CCDS60215.1
    UniProtKB/Swiss-Prot
    Q96S66
    Related
    ENSP00000358986.2, ENST00000369969.6
    Conserved Domains (1) summary
    pfam05934
    Location:14430
    MCLC; Mid-1-related chloride channel (MCLC)
  3. NM_001278203.1NP_001265132.1  chloride channel CLIC-like protein 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001265132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks four consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AB018304, AB052918, AL449266, BQ685798
    Consensus CDS
    CCDS60214.1
    UniProtKB/Swiss-Prot
    Q96S66
    Related
    ENSP00000358985.2, ENST00000369968.6
    Conserved Domains (1) summary
    pfam05934
    Location:14366
    MCLC; Mid-1-related chloride channel (MCLC)
  4. NM_001377458.1NP_001364387.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  5. NM_001377459.1NP_001364388.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  6. NM_001377460.1NP_001364389.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  7. NM_001377461.1NP_001364390.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
    Related
    ENSP00000349456.2, ENST00000356970.6
  8. NM_001377462.1NP_001364391.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  9. NM_001377463.1NP_001364392.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  10. NM_001377464.1NP_001364393.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  11. NM_001377465.1NP_001364394.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  12. NM_001377466.1NP_001364395.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  13. NM_001377467.1NP_001364396.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  14. NM_001377468.1NP_001364397.1  chloride channel CLIC-like protein 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  15. NM_001377469.1NP_001364398.1  chloride channel CLIC-like protein 1 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL449266
  16. NM_001377470.1NP_001364399.1  chloride channel CLIC-like protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL449266
  17. NM_015127.5NP_055942.1  chloride channel CLIC-like protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_055942.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 5' UTR and in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL449266
    Consensus CDS
    CCDS793.1
    UniProtKB/Swiss-Prot
    Q96S66
    UniProtKB/TrEMBL
    A0A024R095
    Related
    ENSP00000358987.3, ENST00000369970.7
    Conserved Domains (1) summary
    pfam05934
    Location:14501
    MCLC; Mid-1-related chloride channel (MCLC)

RNA

  1. NR_165299.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL449266

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    108929505..108963484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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