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N4BP3 NEDD4 binding protein 3 [ Homo sapiens (human) ]

Gene ID: 23138, updated on 5-Aug-2022

Summary

Official Symbol
N4BP3provided by HGNC
Official Full Name
NEDD4 binding protein 3provided by HGNC
Primary source
HGNC:HGNC:29852
See related
Ensembl:ENSG00000145911 MIM:619140; AllianceGenome:HGNC:29852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LZTS4
Summary
Predicted to be involved in nervous system development. Predicted to be located in axon and dendrite. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta (RPKM 5.5), esophagus (RPKM 3.2) and 20 other tissues See more
Orthologs
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Genomic context

See N4BP3 in Genome Data Viewer
Location:
5q35.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (178113532..178127034)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (178663763..178676321)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177540533..177553082)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr5.4886 Neighboring gene uncharacterized LOC105377754 Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene Sharpr-MPRA regulatory region 11782 Neighboring gene NHP2 ribonucleoprotein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0341

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015111.2NP_055926.1  NEDD4-binding protein 3

    See identical proteins and their annotated locations for NP_055926.1

    Status: VALIDATED

    Source sequence(s)
    AC136632
    Consensus CDS
    CCDS34307.1
    UniProtKB/Swiss-Prot
    O15049, Q7Z6I3
    Related
    ENSP00000274605.4, ENST00000274605.6
    Conserved Domains (1) summary
    pfam06818
    Location:368526
    Fez1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    178113532..178127034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534473.2XP_011532775.1  NEDD4-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011532775.1

    UniProtKB/Swiss-Prot
    O15049, Q7Z6I3
    Conserved Domains (1) summary
    pfam06818
    Location:368526
    Fez1
  2. XM_011534474.2XP_011532776.1  NEDD4-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011532776.1

    UniProtKB/Swiss-Prot
    O15049, Q7Z6I3
    Conserved Domains (1) summary
    pfam06818
    Location:368526
    Fez1
  3. XM_047416998.1XP_047272954.1  NEDD4-binding protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z6I3
  4. XM_047416997.1XP_047272953.1  NEDD4-binding protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q7Z6I3

RNA

  1. XR_941094.2 RNA Sequence

  2. XR_941093.2 RNA Sequence

  3. XR_007058594.1 RNA Sequence

  4. XR_007058596.1 RNA Sequence

  5. XR_007058597.1 RNA Sequence

  6. XR_007058595.1 RNA Sequence

  7. XR_007058598.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    178663763..178676321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)