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ATP10B ATPase phospholipid transporting 10B (putative) [ Homo sapiens (human) ]

Gene ID: 23120, updated on 19-Jun-2019

Summary

Official Symbol
ATP10Bprovided by HGNC
Official Full Name
ATPase phospholipid transporting 10B (putative)provided by HGNC
Primary source
HGNC:HGNC:13543
See related
Ensembl:ENSG00000118322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPVB
Expression
Biased expression in colon (RPKM 23.9), duodenum (RPKM 11.1) and 7 other tissues See more
Orthologs

Genomic context

See ATP10B in Genome Data Viewer
Location:
5q34
Exon count:
28
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (160563120..160929411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159990127..160279219, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10249 Neighboring gene MIR3142 host gene Neighboring gene microRNA 146a Neighboring gene long intergenic non-protein coding RNA 2159 Neighboring gene uncharacterized LOC105377693

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21477, KIAA0715

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid translocation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable phospholipid-transporting ATPase VB
Names
ATPase, class V, type 10B
P4-ATPase flippase complex alpha subunit ATP10B
NP_001353581.1
NP_001353582.1
NP_001353583.1
NP_001353584.1
NP_001353585.1
NP_001353586.1
NP_001353587.1
NP_079429.2
XP_011532770.1
XP_011532771.1
XP_011532774.1
XP_016864741.1
XP_016864742.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366652.1NP_001353581.1  probable phospholipid-transporting ATPase VB isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008388, AC008456, AC011363, AC091928
    Conserved Domains (1) summary
    cd02073
    Location:681213
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  2. NM_001366653.2NP_001353582.1  probable phospholipid-transporting ATPase VB isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008456, AC011363, AC091928
    Conserved Domains (1) summary
    cl21460
    Location:68455
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  3. NM_001366654.2NP_001353583.1  probable phospholipid-transporting ATPase VB isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008456, AC011363, AC091928
  4. NM_001366655.1NP_001353584.1  probable phospholipid-transporting ATPase VB isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008388, AC008456, AC011363, AC091928
    Conserved Domains (1) summary
    cd02073
    Location:681213
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  5. NM_001366656.2NP_001353585.1  probable phospholipid-transporting ATPase VB isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008456, AC011363, AC091928
    Conserved Domains (1) summary
    cl21460
    Location:68455
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  6. NM_001366657.1NP_001353586.1  probable phospholipid-transporting ATPase VB isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008388, AC008456, AC011363, AC091928
    Conserved Domains (1) summary
    cd02073
    Location:681201
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  7. NM_001366658.2NP_001353587.1  probable phospholipid-transporting ATPase VB isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008456, AC011363
    Conserved Domains (1) summary
    cl21460
    Location:40427
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  8. NM_025153.3NP_079429.2  probable phospholipid-transporting ATPase VB isoform 1

    See identical proteins and their annotated locations for NP_079429.2

    Status: VALIDATED

    Source sequence(s)
    AB018258, AC011363, AK025294, AK090832
    Consensus CDS
    CCDS43394.1
    UniProtKB/Swiss-Prot
    O94823
    Related
    ENSP00000313600.5, ENST00000327245.10
    Conserved Domains (1) summary
    cd02073
    Location:681213
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    160563120..160929411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009252.1XP_016864741.1  probable phospholipid-transporting ATPase VB isoform X2

    Conserved Domains (1) summary
    cd02073
    Location:681201
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  2. XM_011534468.2XP_011532770.1  probable phospholipid-transporting ATPase VB isoform X1

    See identical proteins and their annotated locations for XP_011532770.1

    UniProtKB/Swiss-Prot
    O94823
    Conserved Domains (1) summary
    cd02073
    Location:681213
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  3. XM_011534469.1XP_011532771.1  probable phospholipid-transporting ATPase VB isoform X1

    See identical proteins and their annotated locations for XP_011532771.1

    UniProtKB/Swiss-Prot
    O94823
    Conserved Domains (1) summary
    cd02073
    Location:681213
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  4. XM_017009253.1XP_016864742.1  probable phospholipid-transporting ATPase VB isoform X4

    Conserved Domains (5) summary
    TIGR01652
    Location:661265
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:721798
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:60117
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:10811253
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:10501098
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  5. XM_011534472.2XP_011532774.1  probable phospholipid-transporting ATPase VB isoform X3

    See identical proteins and their annotated locations for XP_011532774.1

    Related
    ENSP00000493802.1, ENST00000642502.1
    Conserved Domains (5) summary
    TIGR01652
    Location:391304
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:693770
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:3287
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:10531292
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:10221070
    HAD_like; Haloacid Dehalogenase-like Hydrolases
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