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SWAP70 switching B cell complex subunit SWAP70 [ Homo sapiens (human) ]

Gene ID: 23075, updated on 7-Dec-2018

Summary

Official Symbol
SWAP70provided by HGNC
Official Full Name
switching B cell complex subunit SWAP70provided by HGNC
Primary source
HGNC:HGNC:17070
See related
Ensembl:ENSG00000133789 MIM:604762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC321; SWAP-70
Expression
Ubiquitous expression in lymph node (RPKM 33.7), spleen (RPKM 30.6) and 24 other tissues See more
Orthologs

Genomic context

See SWAP70 in Genome Data Viewer
Location:
11p15.4
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (9664077..9752991)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9685624..9774508)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a pseudogene 65 Neighboring gene ribosomal protein L21 pseudogene 97 Neighboring gene RNA, 7SK small nuclear pseudogene 50 Neighboring gene uncharacterized LOC105369149 Neighboring gene uncharacterized LOC440028 Neighboring gene SBF2 antisense RNA 1 Neighboring gene SET binding factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human SWAP switching B-cell complex 70kDa subunit (SWAP70) at amino acid residues 566-567 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39540, KIAA0640

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 
isotype switching IEA
Inferred from Electronic Annotation
more info
 
negative regulation of actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell-cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-serine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mast cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
switch-associated protein 70
Names
SWAP switching B-cell complex 70kDa subunit
SWAP switching B-cell complex subunit 70

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297714.1NP_001284643.1  switch-associated protein 70 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC026250, AI693686, AK096859, BC000616
    Consensus CDS
    CCDS73257.1
    UniProtKB/Swiss-Prot
    Q9UH65
    UniProtKB/TrEMBL
    B3KUB9, E7EMB1
    Related
    ENSP00000399056.2, ENST00000447399.6
    Conserved Domains (2) summary
    cd13273
    Location:146255
    PH_SWAP-70; Switch-associated protein-70 Pleckstrin homology (PH) domain
    pfam00169
    Location:153248
    PH; PH domain
  2. NM_015055.4NP_055870.2  switch-associated protein 70 isoform 1

    See identical proteins and their annotated locations for NP_055870.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC026250, AI693686, AK096859, BC000616
    Consensus CDS
    CCDS31426.1
    UniProtKB/Swiss-Prot
    Q9UH65
    UniProtKB/TrEMBL
    B3KUB9
    Related
    ENSP00000315630.6, ENST00000318950.10
    Conserved Domains (2) summary
    cd13273
    Location:204313
    PH_SWAP-70; Switch-associated protein-70 Pleckstrin homology (PH) domain
    cl25732
    Location:332549
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    9664077..9752991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252830.4XP_005252887.1  switch-associated protein 70 isoform X1

    Conserved Domains (2) summary
    cd13273
    Location:55164
    PH_SWAP-70; Switch-associated protein-70 Pleckstrin homology (PH) domain
    pfam00169
    Location:62157
    PH; PH domain
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