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CLUAP1 clusterin associated protein 1 [ Homo sapiens (human) ]

Gene ID: 23059, updated on 8-Oct-2018

Summary

Official Symbol
CLUAP1provided by HGNC
Official Full Name
clusterin associated protein 1provided by HGNC
Primary source
HGNC:HGNC:19009
See related
Ensembl:ENSG00000103351 MIM:616787; Vega:OTTHUMG00000177581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAP22; IFT38; CFAP22
Summary
The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Broad expression in testis (RPKM 8.8), endometrium (RPKM 6.3) and 25 other tissues See more
Orthologs

Genomic context

See CLUAP1 in Genome Data Viewer
Location:
16p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (3500931..3539048)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3550945..3589048)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 60, NatF catalytic subunit Neighboring gene microRNA 6126 Neighboring gene chromosome 16 open reading frame 90 Neighboring gene ribosomal protein L18 pseudogene 12 Neighboring gene uncharacterized LOC101929732 Neighboring gene NLR family CARD domain containing 3 Neighboring gene uncharacterized LOC105371060 Neighboring gene SLX4 structure-specific endonuclease subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • Intraflagellar transport, organism-specific biosystem (from REACTOME)
    Intraflagellar transport, organism-specific biosystemIntraflagellar transport (IFT) is a motor-based process that controls the anterograde and retrograde transport of large protein complexes, ciliary cargo and structural components along the ciliary ax...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13297, KIAA0643

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intraciliary transport involved in cilium assembly TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ciliary tip TAS
Traceable Author Statement
more info
 
cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
clusterin-associated protein 1
Names
cilia and flagella associated protein 22
flagellar associated protein 22, qilin-like protein, homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047131.1 RefSeqGene

    Range
    5001..43104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330454.1NP_001317383.1  clusterin-associated protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3)
    Source sequence(s)
    AC004224, AC004494, BQ446386
    Consensus CDS
    CCDS81942.1
    UniProtKB/TrEMBL
    J3KNW5
    Related
    ENSP00000344392.5, ENST00000341633.9
  2. NM_015041.2NP_055856.1  clusterin-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB089691, AC004494, AK023319, BQ446386, DA502615, T49451
    Consensus CDS
    CCDS32381.1
    UniProtKB/Swiss-Prot
    Q96AJ1
    Related
    ENSP00000460850.1, OTTHUMP00000257140, ENST00000576634.5, OTTHUMT00000437883
    Conserved Domains (2) summary
    pfam06409
    Location:210278
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam10234
    Location:19278
    Cluap1; Clusterin-associated protein-1
  3. NM_024793.2NP_079069.1  clusterin-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_079069.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC004494, AK023319, AK023359, BQ446386, T49451
    Consensus CDS
    CCDS45398.1
    UniProtKB/Swiss-Prot
    Q96AJ1
    Related
    ENSP00000460889.1, OTTHUMP00000257147, ENST00000572600.5, OTTHUMT00000437890
    Conserved Domains (1) summary
    pfam06409
    Location:44112
    NPIP; Nuclear pore complex interacting protein (NPIP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    3500931..3539048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023073.1XP_016878562.1  clusterin-associated protein 1 isoform X1

  2. XM_006720867.3XP_006720930.1  clusterin-associated protein 1 isoform X2

    Conserved Domains (2) summary
    pfam06409
    Location:138206
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam10234
    Location:1206
    Cluap1; Clusterin-associated protein-1

RNA

  1. XR_001751874.2 RNA Sequence

  2. XR_002957794.1 RNA Sequence

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