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CLUAP1 clusterin associated protein 1 [ Homo sapiens (human) ]

Gene ID: 23059, updated on 28-Sep-2022

Summary

Official Symbol
CLUAP1provided by HGNC
Official Full Name
clusterin associated protein 1provided by HGNC
Primary source
HGNC:HGNC:19009
See related
Ensembl:ENSG00000103351 MIM:616787; AllianceGenome:HGNC:19009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAP22; IFT38; CFAP22
Summary
The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Broad expression in testis (RPKM 8.8), endometrium (RPKM 6.3) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See CLUAP1 in Genome Data Viewer
Location:
16p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3495427..3539048)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3528262..3566307)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3551004..3589048)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene N-alpha-acetyltransferase 60, NatF catalytic subunit Neighboring gene Sharpr-MPRA regulatory region 11363 Neighboring gene microRNA 6126 Neighboring gene chromosome 16 open reading frame 90 Neighboring gene ribosomal protein L18 pseudogene 12 Neighboring gene uncharacterized LOC101929732 Neighboring gene NLR family CARD domain containing 3 Neighboring gene uncharacterized LOC124903632

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13297, KIAA0643

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axoneme assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cilium assembly IC
Inferred by Curator
more info
PubMed 
involved_in floor plate formation IEA
Inferred from Electronic Annotation
more info
 
involved_in heart looping IEA
Inferred from Electronic Annotation
more info
 
involved_in intraciliary anterograde transport IC
Inferred by Curator
more info
PubMed 
involved_in left/right pattern formation IEA
Inferred from Electronic Annotation
more info
 
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ciliary base IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary tip TAS
Traceable Author Statement
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cilium IC
Inferred by Curator
more info
PubMed 
located_in cilium TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
part_of intraciliary transport particle A IEA
Inferred from Electronic Annotation
more info
 
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of intraciliary transport particle B IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
clusterin-associated protein 1
Names
cilia and flagella associated protein 22
flagellar associated protein 22, qilin-like protein, homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047131.2 RefSeqGene

    Range
    10579..48623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330454.2NP_001317383.1  clusterin-associated protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3)
    Source sequence(s)
    AC004224, AC004494, BQ446386
    Consensus CDS
    CCDS81942.1
    UniProtKB/TrEMBL
    J3KNW5
    Related
    ENSP00000344392.5, ENST00000341633.9
  2. NM_015041.3NP_055856.1  clusterin-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB089691, AC004494, AK023319, BQ446386, T49451
    Consensus CDS
    CCDS32381.1
    UniProtKB/Swiss-Prot
    Q96AJ1, Q9H8T1
    Related
    ENSP00000460850.1, ENST00000576634.6
    Conserved Domains (2) summary
    pfam06409
    Location:210278
    NPIP; Nuclear pore complex interacting protein (NPIP)
    pfam10234
    Location:19278
    Cluap1; Clusterin-associated protein-1
  3. NM_024793.3NP_079069.1  clusterin-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_079069.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC004494, AK023319, AK023359, BQ446386, T49451
    Consensus CDS
    CCDS45398.1
    UniProtKB/Swiss-Prot
    Q96AJ1
    Related
    ENSP00000460889.1, ENST00000572600.5
    Conserved Domains (1) summary
    pfam06409
    Location:44112
    NPIP; Nuclear pore complex interacting protein (NPIP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3495427..3539048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433797.1XP_047289753.1  clusterin-associated protein 1 isoform X1

  2. XM_047433800.1XP_047289756.1  clusterin-associated protein 1 isoform X5

  3. XM_047433798.1XP_047289754.1  clusterin-associated protein 1 isoform X2

  4. XM_047433799.1XP_047289755.1  clusterin-associated protein 1 isoform X3

  5. XM_017023073.2XP_016878562.1  clusterin-associated protein 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3528262..3566307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)