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FOXM1 forkhead box M1 [ Homo sapiens (human) ]

Gene ID: 2305, updated on 13-Jan-2019

Summary

Official Symbol
FOXM1provided by HGNC
Official Full Name
forkhead box M1provided by HGNC
Primary source
HGNC:HGNC:3818
See related
Ensembl:ENSG00000111206 MIM:602341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPP2; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11; TRIDENT; MPHOSPH2
Summary
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Expression
Broad expression in testis (RPKM 16.1), bone marrow (RPKM 11.2) and 16 other tissues See more
Orthologs

Genomic context

See FOXM1 in Genome Data Viewer
Location:
12p13.33
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (2857680..2877155, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (2966846..2986321, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene testis expressed 52 Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene tubby like protein 3 Neighboring gene RNA, U6 small nuclear 1315, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle TAS
Traceable Author Statement
more info
 
regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
forkhead box protein M1
Names
Forkhead, drosophila, homolog-like 16
HNF-3/fork-head homolog 11
M-phase phosphoprotein 2
MPM-2 reactive phosphoprotein 2
a novel forkhead box M1 isoform FOXM1D
forkhead box M1-D
forkhead-related protein FKHL16
hepatocyte nuclear factor 3 forkhead homolog 11
transcription factor Trident
winged-helix factor from INS-1 cells

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029590.1 RefSeqGene

    Range
    5001..24475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243088.1NP_001230017.1  forkhead box protein M1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK313845, AW780338, DB137846, U74612
    Consensus CDS
    CCDS76506.1
    UniProtKB/Swiss-Prot
    Q08050
    UniProtKB/TrEMBL
    A0A0D9SFF0
    Related
    ENSP00000486536.1, ENST00000627656.2
    Conserved Domains (1) summary
    cd00059
    Location:235310
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  2. NM_001243089.1NP_001230018.1  forkhead box protein M1 isoform 5

    See identical proteins and their annotated locations for NP_001230018.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK291206, AW780338, DB137846, U83113
    UniProtKB/Swiss-Prot
    Q08050
    UniProtKB/TrEMBL
    A8K591
    Conserved Domains (1) summary
    cd00059
    Location:235310
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  3. NM_021953.3NP_068772.2  forkhead box protein M1 isoform 2

    See identical proteins and their annotated locations for NP_068772.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AW780338, DB137846, U83113
    Consensus CDS
    CCDS8515.1
    UniProtKB/Swiss-Prot
    Q08050
    UniProtKB/TrEMBL
    Q53Y49
    Related
    ENSP00000352901.3, ENST00000359843.7
    Conserved Domains (2) summary
    cd00059
    Location:236311
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    cl28033
    Location:402711
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  4. NM_202002.2NP_973731.1  forkhead box protein M1 isoform 1

    See identical proteins and their annotated locations for NP_973731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AW780338, DB137846, U74612
    Consensus CDS
    CCDS8516.1
    UniProtKB/Swiss-Prot
    Q08050
    Related
    ENSP00000342307.2, ENST00000342628.6
    Conserved Domains (2) summary
    cd00059
    Location:236311
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    cl28033
    Location:504749
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  5. NM_202003.2NP_973732.1  forkhead box protein M1 isoform 3

    See identical proteins and their annotated locations for NP_973732.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AW780338, DB137846, U74613
    Consensus CDS
    CCDS8517.1
    UniProtKB/Swiss-Prot
    Q08050
    Related
    ENSP00000354492.3, ENST00000361953.7
    Conserved Domains (1) summary
    cd00059
    Location:236311
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    2857680..2877155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520930.3XP_011519232.1  forkhead box protein M1 isoform X2

    Conserved Domains (1) summary
    cd00059
    Location:235310
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  2. XM_011520931.3XP_011519233.1  forkhead box protein M1 isoform X3

    Conserved Domains (1) summary
    cd00059
    Location:236311
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  3. XM_005253676.4XP_005253733.1  forkhead box protein M1 isoform X1

    Conserved Domains (1) summary
    cd00059
    Location:236311
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  4. XM_011520934.3XP_011519236.1  forkhead box protein M1 isoform X6

    Conserved Domains (1) summary
    cd00059
    Location:236311
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  5. XM_011520935.1XP_011519237.1  forkhead box protein M1 isoform X7

    Conserved Domains (1) summary
    cd00059
    Location:236311
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  6. XM_011520933.1XP_011519235.1  forkhead box protein M1 isoform X5

    Conserved Domains (1) summary
    cd00059
    Location:236311
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  7. XM_011520932.1XP_011519234.1  forkhead box protein M1 isoform X4

    Conserved Domains (1) summary
    cd00059
    Location:236311
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RNA

  1. XR_931507.1 RNA Sequence

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