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Foxm1 forkhead box M1 [ Mus musculus (house mouse) ]

Gene ID: 14235, updated on 10-Mar-2024

Summary

Official Symbol
Foxm1provided by MGI
Official Full Name
forkhead box M1provided by MGI
Primary source
MGI:MGI:1347487
See related
Ensembl:ENSMUSG00000001517 AllianceGenome:MGI:1347487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WIN; Mpm2; Fkh16; Foxm1b; HFH-11B; MPHOSPH2
Summary
Enables transcription cis-regulatory region binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of double-strand break repair; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including liver development; positive regulation of transcription by RNA polymerase II; and vasculogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study hepatocellular carcinoma; lung cancer; and type 2 diabetes mellitus. Orthologous to human FOXM1 (forkhead box M1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 46.4), limb E14.5 (RPKM 38.1) and 20 other tissues See more
Orthologs
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Genomic context

See Foxm1 in Genome Data Viewer
Location:
6 F3; 6 62.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128339957..128352849)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128362994..128375886)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TUB like protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E4867 Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene STARR-positive B cell enhancer ABC_E8833 Neighboring gene testis expressed 52 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E4868 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4869 Neighboring gene FK506 binding protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
forkhead box protein M1
Names
forkhead homolog 16
trident
winged-helix transcription factor Trident

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008021.4NP_032047.4  forkhead box protein M1

    See identical proteins and their annotated locations for NP_032047.4

    Status: VALIDATED

    Source sequence(s)
    BC065067, BU702111
    Consensus CDS
    CCDS20570.1
    UniProtKB/TrEMBL
    Q6P1H7, Q8C7V5
    Related
    ENSMUSP00000073041.7, ENSMUST00000073316.13
    Conserved Domains (1) summary
    cd00059
    Location:234309
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    128339957..128352849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)