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KIF21B kinesin family member 21B [ Homo sapiens (human) ]

Gene ID: 23046, updated on 5-May-2024

Summary

Official Symbol
KIF21Bprovided by HGNC
Official Full Name
kinesin family member 21Bprovided by HGNC
Primary source
HGNC:HGNC:29442
See related
Ensembl:ENSG00000116852 MIM:608322; AllianceGenome:HGNC:29442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Biased expression in bone marrow (RPKM 12.6), brain (RPKM 10.5) and 11 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
1q32.1
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (200969390..201023714, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (200226336..200280656, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200938518..200992842, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200859988-200860816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200863922-200864432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200864433-200864944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200864945-200865455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200866179-200866766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200866767-200867356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1682 Neighboring gene innate immunity activator Neighboring gene RNA, U6 small nuclear 704, pseudogene Neighboring gene maestro heat like repeat family member 3, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2304 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:200945792-200946991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200969230-200969730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200985675-200986222 Neighboring gene Sharpr-MPRA regulatory region 10908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200991037-200991644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1685 Neighboring gene uncharacterized LOC101929305 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:200993410-200993567 Neighboring gene Sharpr-MPRA regulatory region 14143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201021057-201021557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201022145-201023102 Neighboring gene calcium voltage-gated channel subunit alpha1 S Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201028065-201028818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201031613-201032386 Neighboring gene uncharacterized LOC124904481

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
EBI GWAS Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ16314

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
kinesin-like protein KIF21B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047130.1 RefSeqGene

    Range
    4987..59311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252100.2NP_001239029.1  kinesin-like protein KIF21B isoform 1

    See identical proteins and their annotated locations for NP_001239029.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB007918, AL358473, AM177180, BC052964
    Consensus CDS
    CCDS58056.1
    UniProtKB/Swiss-Prot
    B2RP62, B7ZMI0, O75037, Q5T4J3
    UniProtKB/TrEMBL
    Q2UVF0
    Related
    ENSP00000411831.2, ENST00000422435.2
    Conserved Domains (8) summary
    smart00129
    Location:9377
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13061614
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:13051613
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7371
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam12474
    Location:660794
    PKK; Polo kinase kinase
    pfam16034
    Location:678806
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:13121346
    7WD40; WD40 repeat [structural motif]
    cl09111
    Location:9541102
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. NM_001252102.2NP_001239031.1  kinesin-like protein KIF21B isoform 3

    See identical proteins and their annotated locations for NP_001239031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB007918, AL358473, BC052964, BC137281, DR002414
    Consensus CDS
    CCDS58055.1
    UniProtKB/TrEMBL
    Q2UVF0
    Related
    ENSP00000433808.1, ENST00000461742.7
    Conserved Domains (4) summary
    cd00200
    Location:13051613
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7371
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    sd00039
    Location:13121346
    7WD40; WD40 repeat [structural motif]
    cl25732
    Location:3661094
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001252103.2NP_001239032.1  kinesin-like protein KIF21B isoform 4

    See identical proteins and their annotated locations for NP_001239032.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR, lacks an in-frame exon in the coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB007918, AL358473, BC052964, BC137281, BC144557, DR002414
    Consensus CDS
    CCDS58054.1
    UniProtKB/TrEMBL
    Q2UVF0
    Related
    ENSP00000353724.5, ENST00000360529.9
    Conserved Domains (8) summary
    smart00129
    Location:9377
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:12931602
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:12921600
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7371
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam12474
    Location:660794
    PKK; Polo kinase kinase
    pfam16034
    Location:678806
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:12991333
    7WD40; WD40 repeat [structural motif]
    cl09111
    Location:9541102
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  4. NM_017596.4NP_060066.2  kinesin-like protein KIF21B isoform 2

    See identical proteins and their annotated locations for NP_060066.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB007918, AL358473, BC052964
    Consensus CDS
    CCDS30965.1
    UniProtKB/TrEMBL
    Q2UVF0
    Related
    ENSP00000328494.2, ENST00000332129.6
    Conserved Domains (8) summary
    smart00129
    Location:9377
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:12931601
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:12921600
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7371
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam12474
    Location:660794
    PKK; Polo kinase kinase
    pfam16034
    Location:678806
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:12991333
    7WD40; WD40 repeat [structural motif]
    cl09111
    Location:9541102
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    200969390..201023714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000731.2XP_016856220.1  kinesin-like protein KIF21B isoform X1

    UniProtKB/TrEMBL
    Q2UVF0
  2. XM_017000732.2XP_016856221.1  kinesin-like protein KIF21B isoform X2

  3. XM_047449818.1XP_047305774.1  kinesin-like protein KIF21B isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    200226336..200280656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335269.1XP_054191244.1  kinesin-like protein KIF21B isoform X1

  2. XM_054335270.1XP_054191245.1  kinesin-like protein KIF21B isoform X2

  3. XM_054335271.1XP_054191246.1  kinesin-like protein KIF21B isoform X3