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KIF21B kinesin family member 21B [ Homo sapiens (human) ]

Gene ID: 23046, updated on 2-Oct-2018

Summary

Official Symbol
KIF21Bprovided by HGNC
Official Full Name
kinesin family member 21Bprovided by HGNC
Primary source
HGNC:HGNC:29442
See related
Ensembl:ENSG00000116852 MIM:608322; Vega:OTTHUMG00000035787
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Biased expression in bone marrow (RPKM 12.6), brain (RPKM 10.5) and 11 other tissues See more
Orthologs

Genomic context

See KIF21B in Genome Data Viewer
Location:
1q32.1
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (200969386..201023700, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200938514..200992828, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene innate immunity activator Neighboring gene RNA, U6 small nuclear 704, pseudogene Neighboring gene maestro heat like repeat family member 3, pseudogene Neighboring gene uncharacterized LOC101929305 Neighboring gene calcium voltage-gated channel subunit alpha1 S Neighboring gene achaete-scute family bHLH transcription factor 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
NHGRI GWA Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
NHGRI GWA Catalog

Pathways from BioSystems

  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16314

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF21B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047130.1 RefSeqGene

    Range
    5001..59315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252100.1NP_001239029.1  kinesin-like protein KIF21B isoform 1

    See identical proteins and their annotated locations for NP_001239029.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB007918, AM177180, BC052964, R42155
    Consensus CDS
    CCDS58056.1
    UniProtKB/Swiss-Prot
    O75037
    UniProtKB/TrEMBL
    Q2UVF0
    Related
    ENSP00000411831.2, OTTHUMP00000228889, ENST00000422435.2, OTTHUMT00000382635
    Conserved Domains (8) summary
    smart00129
    Location:9377
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13061614
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:13051613
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7371
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam12474
    Location:660794
    PKK; Polo kinase kinase
    pfam16034
    Location:678806
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:13121346
    7WD40; WD40 repeat [structural motif]
    cl09111
    Location:9541102
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. NM_001252102.1NP_001239031.1  kinesin-like protein KIF21B isoform 3

    See identical proteins and their annotated locations for NP_001239031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB007918, BC052964, BC137281, DR002414, R42155
    Consensus CDS
    CCDS58055.1
    UniProtKB/Swiss-Prot
    O75037
    Related
    ENSP00000433808.1, OTTHUMP00000228888, ENST00000461742.6, OTTHUMT00000098719
    Conserved Domains (4) summary
    cd00200
    Location:13051613
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7371
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    sd00039
    Location:13121346
    7WD40; WD40 repeat [structural motif]
    cl25732
    Location:3661094
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001252103.1NP_001239032.1  kinesin-like protein KIF21B isoform 4

    See identical proteins and their annotated locations for NP_001239032.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR, lacks an in-frame exon in the coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB007918, BC052964, BC137281, BC144557, DR002414, R42155
    Consensus CDS
    CCDS58054.1
    UniProtKB/Swiss-Prot
    O75037
    Related
    ENSP00000353724.5, OTTHUMP00000228887, ENST00000360529.9, OTTHUMT00000382634
    Conserved Domains (8) summary
    smart00129
    Location:9377
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:12931602
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:12921600
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7371
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam12474
    Location:660794
    PKK; Polo kinase kinase
    pfam16034
    Location:678806
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:12991333
    7WD40; WD40 repeat [structural motif]
    cl09111
    Location:9541102
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  4. NM_017596.3NP_060066.2  kinesin-like protein KIF21B isoform 2

    See identical proteins and their annotated locations for NP_060066.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB007918, BC052964, R42155
    Consensus CDS
    CCDS30965.1
    UniProtKB/Swiss-Prot
    O75037
    Related
    ENSP00000328494.2, OTTHUMP00000033935, ENST00000332129.6, OTTHUMT00000087055
    Conserved Domains (8) summary
    smart00129
    Location:9377
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:12931601
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:12921600
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7371
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam12474
    Location:660794
    PKK; Polo kinase kinase
    pfam16034
    Location:678806
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:12991333
    7WD40; WD40 repeat [structural motif]
    cl09111
    Location:9541102
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    200969386..201023700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000731.1XP_016856220.1  kinesin-like protein KIF21B isoform X1

  2. XM_017000732.1XP_016856221.1  kinesin-like protein KIF21B isoform X2

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