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Kif21b kinesin family member 21B [ Mus musculus (house mouse) ]

Gene ID: 16565, updated on 18-Apr-2024

Summary

Official Symbol
Kif21bprovided by MGI
Official Full Name
kinesin family member 21Bprovided by MGI
Primary source
MGI:MGI:109234
See related
Ensembl:ENSMUSG00000041642 AllianceGenome:MGI:109234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0449; 2610511N21Rik
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cell projection; cytoplasmic vesicle; and cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human KIF21B (kinesin family member 21B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 74.1), whole brain E14.5 (RPKM 48.8) and 15 other tissues See more
Orthologs
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Genomic context

Location:
1 E4; 1 59.61 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136059128..136105739)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136131390..136178001)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1S subunit Neighboring gene STARR-seq mESC enhancer starr_02400 Neighboring gene STARR-positive B cell enhancer ABC_E2562 Neighboring gene STARR-positive B cell enhancer ABC_E1562 Neighboring gene STARR-positive B cell enhancer mm9_chr1:138036481-138036781 Neighboring gene predicted gene 15850 Neighboring gene maestro heat-like repeat family member 3 Neighboring gene innate immunity activator Neighboring gene predicted gene 3878

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • KIAA0449

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic endosome IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF21B
Names
N-5 kinesin
kinesin-like protein KIF6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039472.2NP_001034561.1  kinesin-like protein KIF21B

    See identical proteins and their annotated locations for NP_001034561.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC124550
    Consensus CDS
    CCDS15324.1
    UniProtKB/TrEMBL
    E9Q0A4, F8VQE2
    Related
    ENSMUSP00000074661.5, ENSMUST00000075164.11
    Conserved Domains (8) summary
    smart00129
    Location:9378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:13081617
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:13021615
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam12474
    Location:661795
    PKK; Polo kinase kinase
    pfam16034
    Location:679807
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:13141348
    7WD40; WD40 repeat [structural motif]
    cl09111
    Location:9651101
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RNA

  1. NR_153829.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC124550
    Related
    ENSMUST00000130864.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    136059128..136105739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019962.2: Suppressed sequence

    Description
    NM_019962.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_177126.2: Suppressed sequence

    Description
    NM_177126.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.