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LIMCH1 LIM and calponin homology domains 1 [ Homo sapiens (human) ]

Gene ID: 22998, updated on 2-Nov-2024

Summary

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Official Symbol
LIMCH1provided by HGNC
Official Full Name
LIM and calponin homology domains 1provided by HGNC
Primary source
HGNC:HGNC:29191
See related
Ensembl:ENSG00000064042 MIM:617750; AllianceGenome:HGNC:29191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LMO7B; LIMCH1A
Summary
Enables myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in myosin II complex and stress fiber. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung (RPKM 19.3), spleen (RPKM 14.7) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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See LIMCH1 in Genome Data Viewer
Location:
4p13
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (41359607..41700044)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (41333394..41673808)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (41361624..41702061)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr4:41244640-41244866 Neighboring gene UCHL1 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:41259655-41260155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:41290173-41290673 Neighboring gene ubiquitin C-terminal hydrolase L1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:41329658-41330318 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:41364841-41365502 Neighboring gene ribosomal protein L12 pseudogene 20 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:41434604-41435306 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:41435307-41436010 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:41527060-41527659 Neighboring gene uncharacterized LOC105374423 Neighboring gene uncharacterized LOC105374421 Neighboring gene paired like homeobox 2b polyalanine repeat instability region Neighboring gene olfactory receptor family 5 subfamily M member 14 pseudogene Neighboring gene PHOX2B antisense RNA 1 Neighboring gene paired like homeobox 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LIMCH1 as a New Potential Metastasis Predictor in Breast Cancer. Alifanov VV, et al. Asian Pac J Cancer Prev, 2022 Nov 1. PMID 36444609, Free PMC Article
  2. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Bersini S, et al. Life Sci Alliance, 2020 Jan. PMID 31959624, Free PMC Article
  3. A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease. Halle MK, et al. Br J Cancer, 2021 May. PMID 33723390, Free PMC Article
  4. LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration. Lin YH, et al. Mol Biol Cell, 2017 Apr 15. PMID 28228547, Free PMC Article
  5. LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease. Karlsson T, et al. Lung Cancer, 2018 Nov. PMID 30429017

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LIMCH1 as a New Potential Metastasis Predictor in Breast Cancer.
    Title: LIMCH1 as a New Potential Metastasis Predictor in Breast Cancer.
  2. A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease.
    Title: A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease.
  3. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.
    Title: Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.
  4. LMO7 and LIMCH1 co-localized and co-immunoprecipitated.
    Title: LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease.
  5. LIMCH1 is a negative regulator involved in a new molecular mechanism for the pathogenesis of lung cancer with HUWE1 and p53
    Title: LIMCH1 suppress the growth of lung cancer by interacting with HUWE1 to sustain p53 stability.
  6. Data suggest that LIMCH1 plays a positive role in regulation of NM-II activity through effects on MRLC during cell migration.
    Title: LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration.
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
EBI GWAS Catalog
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43014, MGC72127, DKFZp434I0312, DKFZp686B2470, DKFZp686G2094, DKFZp781C1754, DKFZp781I1455, DKFZp686A01247, DKFZp686G18243

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin II head/neck binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin II head/neck binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin II head/neck binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic actin-based contraction involved in cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of focal adhesion assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of myosin II complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
LIM and calponin homology domains-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112717.4 → NP_001106188.1  LIM and calponin homology domains-containing protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AB029025, AC105389, AK026815, BX537916, CR749205, CR933645
    Consensus CDS
    CCDS54763.1
    UniProtKB/TrEMBL
    B7Z5Q8
    Related
    ENSP00000424645.1, ENST00000512946.5
    Conserved Domains (4) summary
    smart00132
    Location:987 → 1044
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd21278
    Location:23 → 140
    CH_LIMCH1; calponin homology (CH) domain found in LIM and calponin homology domains-containing protein 1
    pfam15949
    Location:250 → 418
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:771 → 808
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001112718.4 → NP_001106189.1  LIM and calponin homology domains-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AB029025, AC105389, AK026815, BX537916, CR749205, CR936664
    Consensus CDS
    CCDS54764.1
    UniProtKB/TrEMBL
    B7Z5Q8
    Related
    ENSP00000424825.1, ENST00000508501.5
    Conserved Domains (4) summary
    smart00132
    Location:986 → 1043
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd21278
    Location:23 → 140
    CH_LIMCH1; calponin homology (CH) domain found in LIM and calponin homology domains-containing protein 1
    pfam15949
    Location:250 → 418
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:770 → 807
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. NM_001112719.4 → NP_001106190.1  LIM and calponin homology domains-containing protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC105389, AK026815, BX537916, CR749205, CR936661
    Consensus CDS
    CCDS47047.1
    UniProtKB/TrEMBL
    B7Z5Q8
    Related
    ENSP00000379840.3, ENST00000396595.7
    Conserved Domains (3) summary
    smart00132
    Location:832 → 889
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96 → 264
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:616 → 653
    GBP_C; Guanylate-binding protein, C-terminal domain

  4. NM_001112720.4 → NP_001106191.1  LIM and calponin homology domains-containing protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, uses an alternate in-frame splice site, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC105389, AK026815, BX537916, CR749205, CR936664, DA786971
    Consensus CDS
    CCDS54765.1
    UniProtKB/TrEMBL
    B7Z5Q8
    Related
    ENSP00000371172.4, ENST00000381753.8
    Conserved Domains (3) summary
    smart00132
    Location:820 → 877
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96 → 252
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:604 → 641
    GBP_C; Guanylate-binding protein, C-terminal domain

  5. NM_001289122.3 → NP_001276051.1  LIM and calponin homology domains-containing protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AB029025, AK026815, BX537916, CR749205, CR936601, CR936658
    Consensus CDS
    CCDS75119.1
    UniProtKB/TrEMBL
    B7Z5Q8
    Related
    ENSP00000424437.1, ENST00000512820.5
    Conserved Domains (5) summary
    pfam06390
    Location:608 → 813
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00132
    Location:999 → 1056
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250 → 405
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:783 → 820
    GBP_C; Guanylate-binding protein, C-terminal domain

  6. NM_001289124.2 → NP_001276053.1  LIM and calponin homology domains-containing protein 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AK026815, BX537916, CR749205, CR936601, CR936610
    Consensus CDS
    CCDS75121.1
    UniProtKB/TrEMBL
    B7Z5Q8
    Related
    ENSP00000425222.1, ENST00000513024.5
    Conserved Domains (3) summary
    smart00132
    Location:840 → 897
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:91 → 246
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:624 → 661
    GBP_C; Guanylate-binding protein, C-terminal domain

  7. NM_001330672.2 → NP_001317601.1  LIM and calponin homology domains-containing protein 1 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream start codon and multiple internal differences, including a large novel segment. The resulting isoform (h) has a longer overall length, but has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AB029025, AC105389, AC108050, AC124009, AK026815, AL831962, BX537916, CR749205, DC325132
    Consensus CDS
    CCDS82919.1
    UniProtKB/TrEMBL
    G5EA03
    Related
    ENSP00000425631.1, ENST00000503057.6
    Conserved Domains (3) summary
    smart00132
    Location:1397 → 1454
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:654 → 802
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1155 → 1192
    GBP_C; Guanylate-binding protein, C-terminal domain

  8. NM_001330674.2 → NP_001317603.1  LIM and calponin homology domains-containing protein 1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AK026815, AK294774, AK299835, BX537916, CR749205, CR936658
    Consensus CDS
    CCDS82920.1
    UniProtKB/TrEMBL
    B7Z2J4, E9PDJ9
    Related
    ENSP00000422864.1, ENST00000509277.5
    Conserved Domains (3) summary
    smart00132
    Location:846 → 903
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96 → 251
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:604 → 641
    GBP_C; Guanylate-binding protein, C-terminal domain

  9. NM_001330784.2 → NP_001317713.1  LIM and calponin homology domains-containing protein 1 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC105389, AC108050, AK026815, BX537916, CR749205, CR936658
    Consensus CDS
    CCDS87221.1
    UniProtKB/TrEMBL
    B7Z5Q8, D6RD46
    Related
    ENSP00000427045.1, ENST00000512632.5

  10. NM_001330786.2 → NP_001317715.1  LIM and calponin homology domains-containing protein 1 isoform k

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) represents use of an alternate promoter and initiates translation at a downstream start codon compared to variant 1.
    Source sequence(s)
    AC105389, AK026815, BC023546, BX537916, CR749205, DC325132
    Consensus CDS
    CCDS87222.1
    UniProtKB/TrEMBL
    B7Z5Q8
    Related
    ENSP00000421242.1, ENST00000511496.5

  11. NM_001330787.2 → NP_001317716.1  LIM and calponin homology domains-containing protein 1 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050, AC124009
    UniProtKB/TrEMBL
    H0Y8P3

  12. NM_001330788.2 → NP_001317717.1  LIM and calponin homology domains-containing protein 1 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050, AC124009
    UniProtKB/TrEMBL
    H0Y8P3

  13. NM_001330789.2 → NP_001317718.1  LIM and calponin homology domains-containing protein 1 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050, AC124009
    UniProtKB/TrEMBL
    B7Z5Q8

  14. NM_001330790.2 → NP_001317719.1  LIM and calponin homology domains-containing protein 1 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050, AC124009
    UniProtKB/TrEMBL
    H0Y8P3

  15. NM_001330791.2 → NP_001317720.1  LIM and calponin homology domains-containing protein 1 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050
    UniProtKB/TrEMBL
    B7Z2J4
    Conserved Domains (4) summary
    smart00132
    Location:1000 → 1057
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250 → 405
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:758 → 795
    GBP_C; Guanylate-binding protein, C-terminal domain

  16. NM_001330792.2 → NP_001317721.1  LIM and calponin homology domains-containing protein 1 isoform q

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050
    UniProtKB/TrEMBL
    B7Z5Q8
    Conserved Domains (4) summary
    smart00132
    Location:974 → 1031
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250 → 405
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:758 → 795
    GBP_C; Guanylate-binding protein, C-terminal domain

  17. NM_001330793.2 → NP_001317722.1  LIM and calponin homology domains-containing protein 1 isoform r

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AC105389, AC108050, AC124009
    UniProtKB/TrEMBL
    H0Y8P3
    Related
    ENSP00000421656.1, ENST00000508466.1

  18. NM_001330982.2 → NP_001317911.1  LIM and calponin homology domains-containing protein 1 isoform s

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AC105389, AC108050, AC124009
    UniProtKB/TrEMBL
    B7Z5Q8

  19. NM_001330983.1 → NP_001317912.1  LIM and calponin homology domains-containing protein 1 isoform t

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AC105389, AC108050, AC124009
    UniProtKB/TrEMBL
    H0Y8P3
    Conserved Domains (3) summary
    smart00132
    Location:861 → 918
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96 → 263
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:616 → 653
    GBP_C; Guanylate-binding protein, C-terminal domain

  20. NM_014988.5 → NP_055803.2  LIM and calponin homology domains-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_055803.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a).
    Source sequence(s)
    AB029025, AC105389, AK026815, BX537916, CR749205
    Consensus CDS
    CCDS33977.1
    UniProtKB/Swiss-Prot
    A8MXC3, E9PHM7, Q503B5, Q5CZB1, Q5CZB6, Q5H9S8, Q68E07, Q6PJ44, Q7Z3G5, Q8N3S9, Q8N6M2, Q9UPQ0
    UniProtKB/TrEMBL
    H0Y8P3
    Related
    ENSP00000316891.7, ENST00000313860.12
    Conserved Domains (4) summary
    smart00132
    Location:1013 → 1070
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250 → 417
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:771 → 808
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    41359607..41700044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513642.2 → XP_011511944.1  LIM and calponin homology domains-containing protein 1 isoform X1

    Conserved Domains (4) summary
    smart00132
    Location:1585 → 1642
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813 → 961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1340 → 1377
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_011513644.2 → XP_011511946.1  LIM and calponin homology domains-containing protein 1 isoform X3

    Conserved Domains (4) summary
    smart00132
    Location:1582 → 1639
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813 → 961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1340 → 1377
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. XM_011513646.2 → XP_011511948.1  LIM and calponin homology domains-containing protein 1 isoform X10

    Conserved Domains (4) summary
    smart00132
    Location:1556 → 1613
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813 → 961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1340 → 1377
    GBP_C; Guanylate-binding protein, C-terminal domain

  4. XM_011513643.2 → XP_011511945.1  LIM and calponin homology domains-containing protein 1 isoform X2

    Conserved Domains (4) summary
    smart00132
    Location:1584 → 1641
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813 → 961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1339 → 1376
    GBP_C; Guanylate-binding protein, C-terminal domain

  5. XM_017007894.2 → XP_016863383.1  LIM and calponin homology domains-containing protein 1 isoform X4

  6. XM_047449833.1 → XP_047305789.1  LIM and calponin homology domains-containing protein 1 isoform X11

  7. XM_011513645.2 → XP_011511947.1  LIM and calponin homology domains-containing protein 1 isoform X8

    Conserved Domains (3) summary
    smart00132
    Location:1557 → 1614
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813 → 961
    DUF4757; Domain of unknown function (DUF4757)

  8. XM_017007896.2 → XP_016863385.1  LIM and calponin homology domains-containing protein 1 isoform X15

  9. XM_005248057.2 → XP_005248114.1  LIM and calponin homology domains-containing protein 1 isoform X5

    Conserved Domains (4) summary
    smart00132
    Location:1560 → 1617
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813 → 961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1315 → 1352
    GBP_C; Guanylate-binding protein, C-terminal domain

  10. XM_017007895.2 → XP_016863384.1  LIM and calponin homology domains-containing protein 1 isoform X7

  11. XM_047449834.1 → XP_047305790.1  LIM and calponin homology domains-containing protein 1 isoform X13

  12. XM_005248058.2 → XP_005248115.1  LIM and calponin homology domains-containing protein 1 isoform X6

    Conserved Domains (4) summary
    smart00132
    Location:1559 → 1616
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813 → 961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1314 → 1351
    GBP_C; Guanylate-binding protein, C-terminal domain

  13. XM_005248060.2 → XP_005248117.1  LIM and calponin homology domains-containing protein 1 isoform X9

    Conserved Domains (4) summary
    smart00132
    Location:1556 → 1613
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813 → 961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1314 → 1351
    GBP_C; Guanylate-binding protein, C-terminal domain

  14. XM_006713996.2 → XP_006714059.1  LIM and calponin homology domains-containing protein 1 isoform X14

    Conserved Domains (4) summary
    smart00132
    Location:1530 → 1587
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813 → 961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:1314 → 1351
    GBP_C; Guanylate-binding protein, C-terminal domain

  15. XM_005248061.2 → XP_005248118.1  LIM and calponin homology domains-containing protein 1 isoform X12

    Conserved Domains (3) summary
    smart00132
    Location:1532 → 1589
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813 → 961
    DUF4757; Domain of unknown function (DUF4757)

  16. XM_011513653.2 → XP_011511955.1  LIM and calponin homology domains-containing protein 1 isoform X16

    UniProtKB/TrEMBL
    H0Y8P3
    Conserved Domains (4) summary
    smart00132
    Location:1041 → 1098
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250 → 417
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:796 → 833
    GBP_C; Guanylate-binding protein, C-terminal domain

  17. XM_047449835.1 → XP_047305791.1  LIM and calponin homology domains-containing protein 1 isoform X19

  18. XM_017007898.2 → XP_016863387.1  LIM and calponin homology domains-containing protein 1 isoform X18

    UniProtKB/TrEMBL
    H0Y8P3

  19. XM_017007900.2 → XP_016863389.1  LIM and calponin homology domains-containing protein 1 isoform X24

    UniProtKB/TrEMBL
    H0Y8P3

  20. XM_011513654.2 → XP_011511956.1  LIM and calponin homology domains-containing protein 1 isoform X17

    UniProtKB/TrEMBL
    B7Z2J4
    Conserved Domains (4) summary
    smart00132
    Location:1029 → 1086
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250 → 405
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:784 → 821
    GBP_C; Guanylate-binding protein, C-terminal domain

  21. XM_047449838.1 → XP_047305794.1  LIM and calponin homology domains-containing protein 1 isoform X23

  22. XM_024453937.2 → XP_024309705.1  LIM and calponin homology domains-containing protein 1 isoform X20

    UniProtKB/TrEMBL
    B7Z2J4
    Conserved Domains (4) summary
    smart00132
    Location:1004 → 1061
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26 → 138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250 → 406
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:759 → 796
    GBP_C; Guanylate-binding protein, C-terminal domain

  23. XM_047449837.1 → XP_047305793.1  LIM and calponin homology domains-containing protein 1 isoform X22

  24. XM_047449840.1 → XP_047305796.1  LIM and calponin homology domains-containing protein 1 isoform X26

  25. XM_047449836.1 → XP_047305792.1  LIM and calponin homology domains-containing protein 1 isoform X21

  26. XM_047449839.1 → XP_047305795.1  LIM and calponin homology domains-containing protein 1 isoform X25

  27. XM_047449841.1 → XP_047305797.1  LIM and calponin homology domains-containing protein 1 isoform X27

  28. XM_017007903.2 → XP_016863392.1  LIM and calponin homology domains-containing protein 1 isoform X28

    UniProtKB/TrEMBL
    H0Y8P3

  29. XM_047449842.1 → XP_047305798.1  LIM and calponin homology domains-containing protein 1 isoform X30

  30. XM_024453938.2 → XP_024309706.1  LIM and calponin homology domains-containing protein 1 isoform X33

    UniProtKB/TrEMBL
    B7Z5Q8
    Conserved Domains (2) summary
    smart00132
    Location:805 → 862
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96 → 264
    DUF4757; Domain of unknown function (DUF4757)

  31. XM_011513655.2 → XP_011511957.1  LIM and calponin homology domains-containing protein 1 isoform X29

    UniProtKB/TrEMBL
    B7Z2J4
    Conserved Domains (3) summary
    smart00132
    Location:875 → 932
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96 → 251
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:630 → 667
    GBP_C; Guanylate-binding protein, C-terminal domain

  32. XM_047449843.1 → XP_047305799.1  LIM and calponin homology domains-containing protein 1 isoform X31

  33. XM_047449844.1 → XP_047305800.1  LIM and calponin homology domains-containing protein 1 isoform X32

  34. XM_047449845.1 → XP_047305801.1  LIM and calponin homology domains-containing protein 1 isoform X34

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    41333394..41673808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349282.1 → XP_054205257.1  LIM and calponin homology domains-containing protein 1 isoform X1

  2. XM_054349284.1 → XP_054205259.1  LIM and calponin homology domains-containing protein 1 isoform X3

  3. XM_054349291.1 → XP_054205266.1  LIM and calponin homology domains-containing protein 1 isoform X10

  4. XM_054349283.1 → XP_054205258.1  LIM and calponin homology domains-containing protein 1 isoform X2

  5. XM_054349285.1 → XP_054205260.1  LIM and calponin homology domains-containing protein 1 isoform X4

  6. XM_054349292.1 → XP_054205267.1  LIM and calponin homology domains-containing protein 1 isoform X11

  7. XM_054349289.1 → XP_054205264.1  LIM and calponin homology domains-containing protein 1 isoform X8

  8. XM_054349296.1 → XP_054205271.1  LIM and calponin homology domains-containing protein 1 isoform X15

  9. XM_054349286.1 → XP_054205261.1  LIM and calponin homology domains-containing protein 1 isoform X5

  10. XM_054349288.1 → XP_054205263.1  LIM and calponin homology domains-containing protein 1 isoform X7

  11. XM_054349294.1 → XP_054205269.1  LIM and calponin homology domains-containing protein 1 isoform X13

  12. XM_054349287.1 → XP_054205262.1  LIM and calponin homology domains-containing protein 1 isoform X6

  13. XM_054349290.1 → XP_054205265.1  LIM and calponin homology domains-containing protein 1 isoform X9

  14. XM_054349295.1 → XP_054205270.1  LIM and calponin homology domains-containing protein 1 isoform X14

  15. XM_054349293.1 → XP_054205268.1  LIM and calponin homology domains-containing protein 1 isoform X12

  16. XM_054349297.1 → XP_054205272.1  LIM and calponin homology domains-containing protein 1 isoform X16

  17. XM_054349300.1 → XP_054205275.1  LIM and calponin homology domains-containing protein 1 isoform X19

  18. XM_054349299.1 → XP_054205274.1  LIM and calponin homology domains-containing protein 1 isoform X18

  19. XM_054349305.1 → XP_054205280.1  LIM and calponin homology domains-containing protein 1 isoform X24

  20. XM_054349298.1 → XP_054205273.1  LIM and calponin homology domains-containing protein 1 isoform X17

  21. XM_054349304.1 → XP_054205279.1  LIM and calponin homology domains-containing protein 1 isoform X23

  22. XM_054349301.1 → XP_054205276.1  LIM and calponin homology domains-containing protein 1 isoform X20

  23. XM_054349303.1 → XP_054205278.1  LIM and calponin homology domains-containing protein 1 isoform X22

  24. XM_054349307.1 → XP_054205282.1  LIM and calponin homology domains-containing protein 1 isoform X26

  25. XM_054349302.1 → XP_054205277.1  LIM and calponin homology domains-containing protein 1 isoform X21

  26. XM_054349306.1 → XP_054205281.1  LIM and calponin homology domains-containing protein 1 isoform X25

  27. XM_054349308.1 → XP_054205283.1  LIM and calponin homology domains-containing protein 1 isoform X27

  28. XM_054349309.1 → XP_054205284.1  LIM and calponin homology domains-containing protein 1 isoform X28

  29. XM_054349311.1 → XP_054205286.1  LIM and calponin homology domains-containing protein 1 isoform X30

  30. XM_054349314.1 → XP_054205289.1  LIM and calponin homology domains-containing protein 1 isoform X33

  31. XM_054349310.1 → XP_054205285.1  LIM and calponin homology domains-containing protein 1 isoform X29

  32. XM_054349312.1 → XP_054205287.1  LIM and calponin homology domains-containing protein 1 isoform X31

  33. XM_054349313.1 → XP_054205288.1  LIM and calponin homology domains-containing protein 1 isoform X32

  34. XM_054349315.1 → XP_054205290.1  LIM and calponin homology domains-containing protein 1 isoform X34

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UPQ0.4 GenPept UniProtKB/Swiss-Prot:Q9UPQ0

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