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LIMCH1 LIM and calponin homology domains 1 [ Homo sapiens (human) ]

Gene ID: 22998, updated on 12-Oct-2019

Summary

Official Symbol
LIMCH1provided by HGNC
Official Full Name
LIM and calponin homology domains 1provided by HGNC
Primary source
HGNC:HGNC:29191
See related
Ensembl:ENSG00000064042 MIM:617750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LMO7B; LIMCH1A
Expression
Broad expression in lung (RPKM 19.3), spleen (RPKM 14.7) and 20 other tissues See more
Orthologs

Genomic context

See LIMCH1 in Genome Data Viewer
Location:
4p13
Exon count:
38
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (41359607..41700044)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (41362802..41702061)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UCHL1 antisense RNA 1 (head to head) Neighboring gene ubiquitin C-terminal hydrolase L1 Neighboring gene ribosomal protein L12 pseudogene 20 Neighboring gene uncharacterized LOC105374423 Neighboring gene uncharacterized LOC105374421 Neighboring gene paired like homeobox 2b polyalanine repeat instability region Neighboring gene olfactory receptor family 5 subfamily M member 14 pseudogene Neighboring gene paired like homeobox 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
NHGRI GWA Catalog
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43014, MGC72127, DKFZp434I0312, DKFZp686B2470, DKFZp686G2094, DKFZp781C1754, DKFZp781I1455, DKFZp686A01247, DKFZp686G18243

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
myosin II head/neck binding IDA
Inferred from Direct Assay
more info
PubMed 
myosin II head/neck binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with myosin II complex IDA
Inferred from Direct Assay
more info
PubMed 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
LIM and calponin homology domains-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112717.4NP_001106188.1  LIM and calponin homology domains-containing protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AB029025, AC105389, AK026815, BX537916, CR749205, CR933645
    Consensus CDS
    CCDS54763.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    Related
    ENSP00000424645.1, ENST00000512946.5
    Conserved Domains (4) summary
    smart00132
    Location:9871044
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250417
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:771808
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_001112718.4NP_001106189.1  LIM and calponin homology domains-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AB029025, AC105389, AK026815, BX537916, CR749205, CR936664
    Consensus CDS
    CCDS54764.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    Related
    ENSP00000424825.1, ENST00000508501.5
    Conserved Domains (4) summary
    smart00132
    Location:9861043
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250417
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:770807
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_001112719.3NP_001106190.1  LIM and calponin homology domains-containing protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC105389, AK026815, AK294774, BX537916, CR749205, CR936661
    Consensus CDS
    CCDS47047.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    UniProtKB/TrEMBL
    B7Z2J4
    Related
    ENSP00000379840.3, ENST00000396595.7
    Conserved Domains (3) summary
    smart00132
    Location:832889
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96263
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:616653
    GBP_C; Guanylate-binding protein, C-terminal domain
  4. NM_001112720.3NP_001106191.1  LIM and calponin homology domains-containing protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, uses an alternate in-frame splice site, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC105389, AK026815, AK294774, BX537916, CR749205, CR936664, DA786971
    Consensus CDS
    CCDS54765.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    UniProtKB/TrEMBL
    B7Z2J4
    Related
    ENSP00000371172.4, ENST00000381753.8
    Conserved Domains (3) summary
    smart00132
    Location:820877
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96251
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:604641
    GBP_C; Guanylate-binding protein, C-terminal domain
  5. NM_001289122.3NP_001276051.1  LIM and calponin homology domains-containing protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AB029025, AK026815, BX537916, CR749205, CR936601, CR936658
    Consensus CDS
    CCDS75119.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    Related
    ENSP00000424437.1, ENST00000512820.5
    Conserved Domains (5) summary
    pfam06390
    Location:608813
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    smart00132
    Location:9991056
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250405
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:783820
    GBP_C; Guanylate-binding protein, C-terminal domain
  6. NM_001289124.2NP_001276053.1  LIM and calponin homology domains-containing protein 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AK026815, BX537916, CR749205, CR936601, CR936610
    Consensus CDS
    CCDS75121.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    Related
    ENSP00000425222.1, ENST00000513024.5
    Conserved Domains (3) summary
    smart00132
    Location:840897
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:91246
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:624661
    GBP_C; Guanylate-binding protein, C-terminal domain
  7. NM_001330672.2NP_001317601.1  LIM and calponin homology domains-containing protein 1 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream start codon and multiple internal differences, including a large novel segment. The resulting isoform (h) has a longer overall length, but has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AB029025, AC105389, AC108050, AC124009, AK026815, AL831962, BX537916, CR749205, DC325132
    Consensus CDS
    CCDS82919.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    UniProtKB/TrEMBL
    G5EA03
    Related
    ENSP00000425631.1, ENST00000503057.6
    Conserved Domains (3) summary
    smart00132
    Location:13971454
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:654802
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:11551192
    GBP_C; Guanylate-binding protein, C-terminal domain
  8. NM_001330674.1NP_001317603.1  LIM and calponin homology domains-containing protein 1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AK026815, AK294774, AK299835, BX537916, CR749205, CR936658
    Consensus CDS
    CCDS82920.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    UniProtKB/TrEMBL
    B7Z2J4, B7Z656, E9PDJ9
    Related
    ENSP00000422864.1, ENST00000509277.5
    Conserved Domains (3) summary
    smart00132
    Location:846903
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96251
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:604641
    GBP_C; Guanylate-binding protein, C-terminal domain
  9. NM_001330784.2NP_001317713.1  LIM and calponin homology domains-containing protein 1 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC105389, AC108050, AK026815, BX537916, CR749205, CR936658
    Consensus CDS
    CCDS87221.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    UniProtKB/TrEMBL
    D6RD46
    Related
    ENSP00000427045.1, ENST00000512632.5
  10. NM_001330786.2NP_001317715.1  LIM and calponin homology domains-containing protein 1 isoform k

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) represents use of an alternate promoter and initiates translation at a downstream start codon compared to variant 1.
    Source sequence(s)
    AC105389, AK026815, BC023546, BX537916, CR749205, DC325132
    Consensus CDS
    CCDS87222.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    Related
    ENSP00000421242.1, ENST00000511496.5
  11. NM_001330787.2NP_001317716.1  LIM and calponin homology domains-containing protein 1 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050, AC124009
  12. NM_001330788.2NP_001317717.1  LIM and calponin homology domains-containing protein 1 isoform m

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050, AC124009
  13. NM_001330789.2NP_001317718.1  LIM and calponin homology domains-containing protein 1 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050, AC124009
  14. NM_001330790.2NP_001317719.1  LIM and calponin homology domains-containing protein 1 isoform o

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050, AC124009
  15. NM_001330791.2NP_001317720.1  LIM and calponin homology domains-containing protein 1 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050
    Conserved Domains (4) summary
    smart00132
    Location:10001057
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250405
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:758795
    GBP_C; Guanylate-binding protein, C-terminal domain
  16. NM_001330792.2NP_001317721.1  LIM and calponin homology domains-containing protein 1 isoform q

    Status: VALIDATED

    Source sequence(s)
    AC095043, AC105389, AC108050
    Conserved Domains (4) summary
    smart00132
    Location:9741031
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250405
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:758795
    GBP_C; Guanylate-binding protein, C-terminal domain
  17. NM_001330793.1NP_001317722.1  LIM and calponin homology domains-containing protein 1 isoform r

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AC105389, AC108050, AC124009
    Related
    ENSP00000421656.1, ENST00000508466.1
  18. NM_001330982.1NP_001317911.1  LIM and calponin homology domains-containing protein 1 isoform s

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AC105389, AC108050, AC124009
  19. NM_001330983.1NP_001317912.1  LIM and calponin homology domains-containing protein 1 isoform t

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) represents use of an alternate promoter compared to variant 1.
    Source sequence(s)
    AC105389, AC108050, AC124009
    Conserved Domains (3) summary
    smart00132
    Location:861918
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96263
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:616653
    GBP_C; Guanylate-binding protein, C-terminal domain
  20. NM_014988.5NP_055803.2  LIM and calponin homology domains-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_055803.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a).
    Source sequence(s)
    AB029025, AC105389, AK026815, BX537916, CR749205
    Consensus CDS
    CCDS33977.1
    UniProtKB/Swiss-Prot
    Q9UPQ0
    Related
    ENSP00000316891.7, ENST00000313860.11
    Conserved Domains (4) summary
    smart00132
    Location:10131070
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250417
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:771808
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    41359607..41700044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513642.1XP_011511944.1  LIM and calponin homology domains-containing protein 1 isoform X1

    Conserved Domains (4) summary
    smart00132
    Location:15851642
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:13401377
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. XM_011513644.1XP_011511946.1  LIM and calponin homology domains-containing protein 1 isoform X3

    Conserved Domains (4) summary
    smart00132
    Location:15821639
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:13401377
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. XM_011513646.1XP_011511948.1  LIM and calponin homology domains-containing protein 1 isoform X10

    Conserved Domains (4) summary
    smart00132
    Location:15561613
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:13401377
    GBP_C; Guanylate-binding protein, C-terminal domain
  4. XM_011513643.1XP_011511945.1  LIM and calponin homology domains-containing protein 1 isoform X2

    Conserved Domains (4) summary
    smart00132
    Location:15841641
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:13391376
    GBP_C; Guanylate-binding protein, C-terminal domain
  5. XM_017007894.1XP_016863383.1  LIM and calponin homology domains-containing protein 1 isoform X4

  6. XM_011513645.1XP_011511947.1  LIM and calponin homology domains-containing protein 1 isoform X8

    Conserved Domains (3) summary
    smart00132
    Location:15571614
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813961
    DUF4757; Domain of unknown function (DUF4757)
  7. XM_017007896.1XP_016863385.1  LIM and calponin homology domains-containing protein 1 isoform X13

  8. XM_005248057.1XP_005248114.1  LIM and calponin homology domains-containing protein 1 isoform X5

    Conserved Domains (4) summary
    smart00132
    Location:15601617
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:13151352
    GBP_C; Guanylate-binding protein, C-terminal domain
  9. XM_017007895.1XP_016863384.1  LIM and calponin homology domains-containing protein 1 isoform X7

  10. XM_005248058.1XP_005248115.1  LIM and calponin homology domains-containing protein 1 isoform X6

    Conserved Domains (4) summary
    smart00132
    Location:15591616
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:13141351
    GBP_C; Guanylate-binding protein, C-terminal domain
  11. XM_005248060.1XP_005248117.1  LIM and calponin homology domains-containing protein 1 isoform X9

    Conserved Domains (4) summary
    smart00132
    Location:15561613
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:13141351
    GBP_C; Guanylate-binding protein, C-terminal domain
  12. XM_006713996.1XP_006714059.1  LIM and calponin homology domains-containing protein 1 isoform X12

    Conserved Domains (4) summary
    smart00132
    Location:15301587
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813961
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:13141351
    GBP_C; Guanylate-binding protein, C-terminal domain
  13. XM_005248061.1XP_005248118.1  LIM and calponin homology domains-containing protein 1 isoform X11

    Conserved Domains (3) summary
    smart00132
    Location:15321589
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:813961
    DUF4757; Domain of unknown function (DUF4757)
  14. XM_017007897.1XP_016863386.1  LIM and calponin homology domains-containing protein 1 isoform X15

  15. XM_011513648.1XP_011511950.1  LIM and calponin homology domains-containing protein 1 isoform X14

    Conserved Domains (4) summary
    smart00132
    Location:15041561
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:732880
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:12591296
    GBP_C; Guanylate-binding protein, C-terminal domain
  16. XM_011513653.1XP_011511955.1  LIM and calponin homology domains-containing protein 1 isoform X18

    Conserved Domains (4) summary
    smart00132
    Location:10411098
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250417
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:796833
    GBP_C; Guanylate-binding protein, C-terminal domain
  17. XM_017007898.1XP_016863387.1  LIM and calponin homology domains-containing protein 1 isoform X20

  18. XM_017007900.1XP_016863389.1  LIM and calponin homology domains-containing protein 1 isoform X22

  19. XM_011513654.1XP_011511956.1  LIM and calponin homology domains-containing protein 1 isoform X19

    Conserved Domains (4) summary
    smart00132
    Location:10291086
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250405
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:784821
    GBP_C; Guanylate-binding protein, C-terminal domain
  20. XM_024453937.1XP_024309705.1  LIM and calponin homology domains-containing protein 1 isoform X21

    Conserved Domains (4) summary
    smart00132
    Location:10041061
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    cd00014
    Location:26138
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15949
    Location:250406
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:759796
    GBP_C; Guanylate-binding protein, C-terminal domain
  21. XM_011513651.2XP_011511953.1  LIM and calponin homology domains-containing protein 1 isoform X17

    See identical proteins and their annotated locations for XP_011511953.1

    Conserved Domains (3) summary
    smart00132
    Location:14261483
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:654802
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:11811218
    GBP_C; Guanylate-binding protein, C-terminal domain
  22. XM_011513649.1XP_011511951.1  LIM and calponin homology domains-containing protein 1 isoform X16

    Conserved Domains (3) summary
    smart00132
    Location:14311488
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:659807
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:11861223
    GBP_C; Guanylate-binding protein, C-terminal domain
  23. XM_017007903.1XP_016863392.1  LIM and calponin homology domains-containing protein 1 isoform X23

  24. XM_024453938.1XP_024309706.1  LIM and calponin homology domains-containing protein 1 isoform X25

    Conserved Domains (2) summary
    smart00132
    Location:805862
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96264
    DUF4757; Domain of unknown function (DUF4757)
  25. XM_011513655.1XP_011511957.1  LIM and calponin homology domains-containing protein 1 isoform X24

    Conserved Domains (3) summary
    smart00132
    Location:875932
    LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    pfam15949
    Location:96251
    DUF4757; Domain of unknown function (DUF4757)
    cl20817
    Location:630667
    GBP_C; Guanylate-binding protein, C-terminal domain
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