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MAST1 microtubule associated serine/threonine kinase 1 [ Homo sapiens (human) ]

Gene ID: 22983, updated on 11-Sep-2019

Summary

Official Symbol
MAST1provided by HGNC
Official Full Name
microtubule associated serine/threonine kinase 1provided by HGNC
Primary source
HGNC:HGNC:19034
See related
Ensembl:ENSG00000105613 MIM:612256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAST; MCCCHCM
Summary
This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]
Expression
Biased expression in brain (RPKM 10.3), testis (RPKM 1.3) and 1 other tissue See more
Orthologs

Genomic context

See MAST1 in Genome Data Viewer
Location:
19p13.13
Exon count:
26
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (12838515..12874952)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12949259..12985766)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribonuclease H2 subunit A Neighboring gene uncharacterized LOC105372281 Neighboring gene retbindin Neighboring gene microRNA 6794 Neighboring gene Sharpr-MPRA regulatory region 6054 Neighboring gene deoxyribonuclease 2, lysosomal Neighboring gene Kruppel like factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0973

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
microtubule-associated serine/threonine-protein kinase 1
Names
syntrophin associated serine/threonine kinase
syntrophin-associated serine/threonine-protein kinase
NP_055790.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054729.1 RefSeqGene

    Range
    9585..46022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014975.3NP_055790.1  microtubule-associated serine/threonine-protein kinase 1

    See identical proteins and their annotated locations for NP_055790.1

    Status: REVIEWED

    Source sequence(s)
    AB023190, AC020934, BM681304, DA769770
    Consensus CDS
    CCDS32921.1
    UniProtKB/Swiss-Prot
    Q9Y2H9
    Related
    ENSP00000251472.3, ENST00000251472.9
    Conserved Domains (4) summary
    smart00220
    Location:374647
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9681050
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:373652
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:61337
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    12838515..12874952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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