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Mast1 microtubule associated serine/threonine kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 56527, updated on 5-Mar-2024

Summary

Official Symbol
Mast1provided by MGI
Official Full Name
microtubule associated serine/threonine kinase 1provided by MGI
Primary source
MGI:MGI:1861901
See related
Ensembl:ENSMUSG00000053693 AllianceGenome:MGI:1861901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SAST; SAST170; 9430008B02Rik
Summary
Enables microtubule binding activity. Involved in brain development and cytoskeleton organization. Located in membrane; neuron projection; and neuronal cell body. Is expressed in nervous system; neural retina; and skeletal muscle. Used to study mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Human ortholog(s) of this gene implicated in mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to human MAST1 (microtubule associated serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 40.5), CNS E18 (RPKM 36.2) and 6 other tissues See more
Orthologs
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Genomic context

See Mast1 in Genome Data Viewer
Location:
8 C3; 8 41.32 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85638482..85672811, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84911853..84946177, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene glutaryl-Coenzyme A dehydrogenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87427053-87427162 Neighboring gene STARR-positive B cell enhancer ABC_E1373 Neighboring gene Kruppel-like transcription factor 1 (erythroid) Neighboring gene deoxyribonuclease II alpha Neighboring gene predicted gene, 38426 Neighboring gene retbindin Neighboring gene STARR-positive B cell enhancer ABC_E6668 Neighboring gene ribonuclease H2, large subunit Neighboring gene STARR-positive B cell enhancer ABC_E2269

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
microtubule-associated serine/threonine-protein kinase 1
Names
syntrophin associated serine/threonine kinase
syntrophin-associated serine-threonine protein kinase
NP_064329.2
XP_006531279.1
XP_006531280.1
XP_030099555.1
XP_036010090.1
XP_036010091.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019945.2NP_064329.2  microtubule-associated serine/threonine-protein kinase 1

    See identical proteins and their annotated locations for NP_064329.2

    Status: VALIDATED

    Source sequence(s)
    AY312167, BC054524, BU701555
    Consensus CDS
    CCDS40415.1
    UniProtKB/Swiss-Prot
    Q7TQG9, Q80TN0, Q9R1L5
    Related
    ENSMUSP00000105363.3, ENSMUST00000109741.9
    Conserved Domains (4) summary
    PHA03247
    Location:12051566
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9701052
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:61337
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85638482..85672811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154197.1XP_036010090.1  microtubule-associated serine/threonine-protein kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TQG9, Q80TN0, Q9R1L5
    Conserved Domains (4) summary
    PHA03247
    Location:12051566
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9701052
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:61337
    DUF1908; Domain of unknown function (DUF1908)
  2. XM_006531216.5XP_006531279.1  microtubule-associated serine/threonine-protein kinase 1 isoform X3

    Conserved Domains (4) summary
    PHA03247
    Location:12011562
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9661048
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:371650
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57333
    DUF1908; Domain of unknown function (DUF1908)
  3. XM_006531217.5XP_006531280.1  microtubule-associated serine/threonine-protein kinase 1 isoform X2

    Conserved Domains (4) summary
    PHA03247
    Location:12001561
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:9651047
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:370649
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:56332
    DUF1908; Domain of unknown function (DUF1908)
  4. XM_030243695.1XP_030099555.1  microtubule-associated serine/threonine-protein kinase 1 isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:497858
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:262344
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  5. XM_036154198.1XP_036010091.1  microtubule-associated serine/threonine-protein kinase 1 isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:497858
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:262344
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...