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TRIM32 tripartite motif containing 32 [ Homo sapiens (human) ]

Gene ID: 22954, updated on 20-Sep-2018

Summary

Official Symbol
TRIM32provided by HGNC
Official Full Name
tripartite motif containing 32provided by HGNC
Primary source
HGNC:HGNC:16380
See related
Ensembl:ENSG00000119401 MIM:602290; Vega:OTTHUMG00000021026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HT2A; BBS11; TATIP; LGMD2H
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 1.6), adrenal (RPKM 1.5) and 24 other tissues See more
Orthologs

Genomic context

See TRIM32 in Genome Data Viewer
Location:
9q33.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (116687302..116701300)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (119360147..119463579)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene astrotactin 2 Neighboring gene uncharacterized LOC107987015 Neighboring gene uncharacterized LOC105376240 Neighboring gene uncharacterized LOC105376239 Neighboring gene uncharacterized LOC105376238

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat expression upregulates TRIM32 expression driving proliferation arrest in human neuronal precursor cells PubMed
tat HIV-1 Tat relocalizes TRIM32 into the nucleus of human neural precursor cells, which causes an increase in ubiquitination of c-Myc PubMed
tat HT2A specifically and precisely binds to the activation domain of HIV-1 Tat (amino acids 1-48), suggesting a role for HT2A in mediating the biological activity of Tat during HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
    Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemPresence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Regulation of innate immune responses to cytosolic DNA, organism-specific biosystem (from REACTOME)
    Regulation of innate immune responses to cytosolic DNA, organism-specific biosystemInnate immune responses are coordinated and regulated to provide an efficient first line of defense against pathogens and at the same time to prevent host self-damage. Here we present some regulatory...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Tat protein binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
myosin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
translation initiation factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin ubiquitination IEA
Inferred from Electronic Annotation
more info
 
axon development IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
muscle cell cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral release from host cell IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chemokine (C-C motif) ligand 20 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-17-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of type I interferon production TAS
Traceable Author Statement
more info
 
response to UV ISS
Inferred from Sequence or Structural Similarity
more info
 
response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
 
tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with striated muscle myosin thick filament ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM32
Names
72 kDa Tat-interacting protein
RING-type E3 ubiquitin transferase TRIM32
TAT-interactive protein, 72-KD
tripartite motif-containing protein 32
zinc-finger protein HT2A
NP_001093149.1
NP_036342.2
XP_005251870.1
XP_011516700.1
XP_016869975.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011619.1 RefSeqGene

    Range
    5001..18999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_211

mRNA and Protein(s)

  1. NM_001099679.1NP_001093149.1  E3 ubiquitin-protein ligase TRIM32

    See identical proteins and their annotated locations for NP_001093149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL133284, BC003154, BI544919, BX091494
    Consensus CDS
    CCDS6817.1
    UniProtKB/Swiss-Prot
    Q13049
    UniProtKB/TrEMBL
    A0A024R843
    Related
    ENSP00000363095.1, OTTHUMP00000022763, ENST00000373983.2, OTTHUMT00000055466
    Conserved Domains (3) summary
    smart00336
    Location:98138
    BBOX; B-Box-type zinc finger
    cd14961
    Location:362644
    NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
    cd16587
    Location:1965
    RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
  2. NM_012210.3NP_036342.2  E3 ubiquitin-protein ligase TRIM32

    See identical proteins and their annotated locations for NP_036342.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL133284, BI544919, BX091494, DN991209
    Consensus CDS
    CCDS6817.1
    UniProtKB/Swiss-Prot
    Q13049
    UniProtKB/TrEMBL
    A0A024R843
    Related
    ENSP00000408292.1, ENST00000450136.1
    Conserved Domains (3) summary
    smart00336
    Location:98138
    BBOX; B-Box-type zinc finger
    cd14961
    Location:362644
    NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
    cd16587
    Location:1965
    RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    116687302..116701300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014486.1XP_016869975.1  E3 ubiquitin-protein ligase TRIM32 isoform X1

    UniProtKB/Swiss-Prot
    Q13049
    UniProtKB/TrEMBL
    A0A024R843
    Conserved Domains (3) summary
    smart00336
    Location:98138
    BBOX; B-Box-type zinc finger
    cd14961
    Location:362644
    NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
    cd16587
    Location:1965
    RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
  2. XM_005251813.4XP_005251870.1  E3 ubiquitin-protein ligase TRIM32 isoform X1

    See identical proteins and their annotated locations for XP_005251870.1

    UniProtKB/Swiss-Prot
    Q13049
    UniProtKB/TrEMBL
    A0A024R843
    Conserved Domains (3) summary
    smart00336
    Location:98138
    BBOX; B-Box-type zinc finger
    cd14961
    Location:362644
    NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
    cd16587
    Location:1965
    RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
  3. XM_011518398.2XP_011516700.1  E3 ubiquitin-protein ligase TRIM32 isoform X1

    See identical proteins and their annotated locations for XP_011516700.1

    UniProtKB/Swiss-Prot
    Q13049
    UniProtKB/TrEMBL
    A0A024R843
    Conserved Domains (3) summary
    smart00336
    Location:98138
    BBOX; B-Box-type zinc finger
    cd14961
    Location:362644
    NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
    cd16587
    Location:1965
    RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins
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