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SIRT2 sirtuin 2 [ Homo sapiens (human) ]

Gene ID: 22933, updated on 5-Dec-2021

Summary

Official Symbol
SIRT2provided by HGNC
Official Full Name
sirtuin 2provided by HGNC
Primary source
HGNC:HGNC:10886
See related
Ensembl:ENSG00000068903 MIM:604480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2; SIR2L; SIR2L2
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in brain (RPKM 37.1), ovary (RPKM 15.7) and 25 other tissues See more
Orthologs
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Genomic context

See SIRT2 in Genome Data Viewer
Location:
19q13.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38878555..38899733, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39369195..39390258, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3140 Neighboring gene Ras and Rab interactor like Neighboring gene NFKB inhibitor beta Neighboring gene coiled-coil glutamate rich protein 2 Neighboring gene seryl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35621, FLJ37491

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+ binding IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent histone deacetylase activity (H4-K16 specific) IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NAD-dependent protein deacetylase activity TAS
Traceable Author Statement
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to caloric restriction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to epinephrine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hepatocyte growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heterochromatin assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in histone H3 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H4 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone deacetylation TAS
Traceable Author Statement
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic nuclear membrane reassembly TAS
Traceable Author Statement
more info
 
involved_in myelination in peripheral nervous system ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of NLRP3 inflammasome complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of oligodendrocyte progenitor proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of striated muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of attachment of spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of oocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rDNA heterochromatin assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of exit from mitosis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to redox state NAS
Non-traceable Author Statement
more info
PubMed 
involved_in substantia nigra development HEP PubMed 
involved_in subtelomeric heterochromatin assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in tubulin deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Schmidt-Lanterman incisure ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin silencing complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in glial cell projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in heterochromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in juxtaparanode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lateral loop ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in meiotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in paranodal junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in paranode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-2
Names
NAD-dependent deacetylase sirtuin-2
SIR2-like protein 2
regulatory protein SIR2 homolog 2
silent information regulator 2
sir2-related protein type 2
sirtuin type 2
NP_001180215.1
NP_036369.2
NP_085096.1
XP_006723174.1
XP_011524956.1
XP_011524957.1
XP_016881989.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193286.2NP_001180215.1  NAD-dependent protein deacetylase sirtuin-2 isoform 3

    See identical proteins and their annotated locations for NP_001180215.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, and also lacks a big segment in the 3' region, resulting in a frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, and a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AF131800, BF529906, DA541045
    Consensus CDS
    CCDS74361.1
    UniProtKB/Swiss-Prot
    Q8IXJ6
    UniProtKB/TrEMBL
    A0A0A0MRF5
    Related
    ENSP00000351809.6, ENST00000358931.9
    Conserved Domains (1) summary
    cd01408
    Location:40228
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  2. NM_012237.4NP_036369.2  NAD-dependent protein deacetylase sirtuin-2 isoform 1

    See identical proteins and their annotated locations for NP_036369.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF083107, BF529906
    Consensus CDS
    CCDS12523.1
    UniProtKB/Swiss-Prot
    Q8IXJ6
    Related
    ENSP00000249396.7, ENST00000249396.12
    Conserved Domains (1) summary
    cd01408
    Location:77331
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  3. NM_030593.3NP_085096.1  NAD-dependent protein deacetylase sirtuin-2 isoform 2

    See identical proteins and their annotated locations for NP_085096.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    BC003012
    Consensus CDS
    CCDS46069.1
    UniProtKB/Swiss-Prot
    Q8IXJ6
    UniProtKB/TrEMBL
    A0A024R0G8
    Related
    ENSP00000375931.2, ENST00000392081.6
    Conserved Domains (2) summary
    cd01408
    Location:40294
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
    pfam16602
    Location:313351
    USP19_linker; Linker region of USP19 deubiquitinase

RNA

  1. NR_034146.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the 5' two exons but has an alternate 5' segment, resulting in an upstream open reading frame (uORF) with strong Kozak signal, as compared to variant 1. The uORF overlaps the downstream ORF (dORF), and inhibits the protein translation from the dORF. Therefore, this transcript is a nonsense-mediated mRNA decay candidate and can not make a functional protein.
    Source sequence(s)
    AK290716, BF346568, BF529906

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38878555..38899733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526655.1XP_011524957.1  NAD-dependent protein deacetylase sirtuin-2 isoform X2

    See identical proteins and their annotated locations for XP_011524957.1

    UniProtKB/Swiss-Prot
    Q8IXJ6
    Conserved Domains (2) summary
    cd01408
    Location:7261
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    pfam16602
    Location:280318
    USP19_linker; Linker region of USP19 deubiquitinase
  2. XM_011526654.2XP_011524956.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

    See identical proteins and their annotated locations for XP_011524956.1

    UniProtKB/Swiss-Prot
    Q8IXJ6
    UniProtKB/TrEMBL
    A0A024R0G8
    Conserved Domains (2) summary
    cd01408
    Location:40294
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
    pfam16602
    Location:313351
    USP19_linker; Linker region of USP19 deubiquitinase
  3. XM_006723111.1XP_006723174.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

    See identical proteins and their annotated locations for XP_006723174.1

    UniProtKB/Swiss-Prot
    Q8IXJ6
    UniProtKB/TrEMBL
    A0A024R0G8
    Conserved Domains (2) summary
    cd01408
    Location:40294
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
    pfam16602
    Location:313351
    USP19_linker; Linker region of USP19 deubiquitinase
  4. XM_017026500.1XP_016881989.1  NAD-dependent protein deacetylase sirtuin-2 isoform X3

RNA

  1. XR_001753639.2 RNA Sequence

  2. XR_001753638.2 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p13 PATCHES

    Range
    288227..309290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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