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SIRT2 sirtuin 2 [ Homo sapiens (human) ]

Gene ID: 22933, updated on 20-Jan-2019

Summary

Official Symbol
SIRT2provided by HGNC
Official Full Name
sirtuin 2provided by HGNC
Primary source
HGNC:HGNC:10886
See related
Ensembl:ENSG00000068903 MIM:604480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2; SIR2L; SIR2L2
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in brain (RPKM 37.1), ovary (RPKM 15.7) and 25 other tissues See more
Orthologs

Genomic context

See SIRT2 in Genome Data Viewer
Location:
19q13.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (38878555..38899862, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39369195..39390502, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene Ras and Rab interactor like Neighboring gene NFKB inhibitor beta Neighboring gene coiled-coil glutamate rich protein 2 Neighboring gene seryl-tRNA synthetase 2, mitochondrial Neighboring gene mitochondrial ribosomal protein S12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35621, FLJ37491

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ binding IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity (H4-K16 specific) IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to caloric restriction ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to epinephrine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin silencing NAS
Non-traceable Author Statement
more info
PubMed 
chromatin silencing at rDNA NAS
Non-traceable Author Statement
more info
PubMed 
chromatin silencing at telomere NAS
Non-traceable Author Statement
more info
PubMed 
gene silencing NAS
Non-traceable Author Statement
more info
PubMed 
hepatocyte growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
histone H3 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H4 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylation TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
myelination in peripheral nervous system ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NLRP3 inflammasome complex assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of oligodendrocyte progenitor proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of striated muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of attachment of spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of execution phase of apoptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of meiotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of oocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ADP-ribosylation NAS
Non-traceable Author Statement
more info
PubMed 
NOT protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of exit from mitosis NAS
Non-traceable Author Statement
more info
PubMed 
regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
response to redox state NAS
Non-traceable Author Statement
more info
PubMed 
substantia nigra development HEP PubMed 
tubulin deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Schmidt-Lanterman incisure ISS
Inferred from Sequence or Structural Similarity
more info
 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing complex NAS
Non-traceable Author Statement
more info
PubMed 
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
glial cell projection ISS
Inferred from Sequence or Structural Similarity
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
juxtaparanode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
 
lateral loop ISS
Inferred from Sequence or Structural Similarity
more info
 
meiotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear heterochromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
paranodal junction ISS
Inferred from Sequence or Structural Similarity
more info
 
paranode region of axon ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-2
Names
NAD-dependent deacetylase sirtuin-2
SIR2-like protein 2
regulatory protein SIR2 homolog 2
silent information regulator 2
sir2-related protein type 2
sirtuin type 2
NP_001180215.1
NP_036369.2
NP_085096.1
XP_006723174.1
XP_011524956.1
XP_011524957.1
XP_016881989.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193286.1NP_001180215.1  NAD-dependent protein deacetylase sirtuin-2 isoform 3

    See identical proteins and their annotated locations for NP_001180215.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, and also lacks a big segment in the 3' region, resulting in a frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, and a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AF131800, BF529906, DA541045
    Consensus CDS
    CCDS74361.1
    UniProtKB/Swiss-Prot
    Q8IXJ6
    UniProtKB/TrEMBL
    A0A0A0MRF5
    Related
    ENSP00000351809.6, ENST00000358931.9
    Conserved Domains (1) summary
    cd01408
    Location:40228
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  2. NM_012237.4NP_036369.2  NAD-dependent protein deacetylase sirtuin-2 isoform 1

    See identical proteins and their annotated locations for NP_036369.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF083107, BF529906
    Consensus CDS
    CCDS12523.1
    UniProtKB/Swiss-Prot
    Q8IXJ6
    Related
    ENSP00000249396.7, ENST00000249396.11
    Conserved Domains (1) summary
    cd01408
    Location:77331
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  3. NM_030593.2NP_085096.1  NAD-dependent protein deacetylase sirtuin-2 isoform 2

    See identical proteins and their annotated locations for NP_085096.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' region, resulting in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    BC003012, BF529906, DA541045
    Consensus CDS
    CCDS46069.1
    UniProtKB/Swiss-Prot
    Q8IXJ6
    UniProtKB/TrEMBL
    A0A024R0G8
    Related
    ENSP00000375931.2, ENST00000392081.6
    Conserved Domains (2) summary
    cd01408
    Location:40294
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    pfam16602
    Location:313351
    USP19_linker; Linker region of USP19 deubiquitinase

RNA

  1. NR_034146.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks the 5' two exons but has an alternate 5' segment, resulting in an upstream open reading frame (uORF) with strong Kozak signal, as compared to variant 1. The uORF overlaps the downstream ORF (dORF), and inhibits the protein translation from the dORF. Therefore, this transcript is a nonsense-mediated mRNA decay candidate and can not make a functional protein.
    Source sequence(s)
    AK290716, BF346568, BF529906

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    38878555..38899862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526655.1XP_011524957.1  NAD-dependent protein deacetylase sirtuin-2 isoform X2

    See identical proteins and their annotated locations for XP_011524957.1

    UniProtKB/Swiss-Prot
    Q8IXJ6
    Conserved Domains (2) summary
    cd01408
    Location:7261
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    pfam16602
    Location:280318
    USP19_linker; Linker region of USP19 deubiquitinase
  2. XM_011526654.2XP_011524956.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

    See identical proteins and their annotated locations for XP_011524956.1

    UniProtKB/Swiss-Prot
    Q8IXJ6
    UniProtKB/TrEMBL
    A0A024R0G8
    Conserved Domains (2) summary
    cd01408
    Location:40294
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    pfam16602
    Location:313351
    USP19_linker; Linker region of USP19 deubiquitinase
  3. XM_006723111.1XP_006723174.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

    See identical proteins and their annotated locations for XP_006723174.1

    UniProtKB/Swiss-Prot
    Q8IXJ6
    UniProtKB/TrEMBL
    A0A024R0G8
    Conserved Domains (2) summary
    cd01408
    Location:40294
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    pfam16602
    Location:313351
    USP19_linker; Linker region of USP19 deubiquitinase
  4. XM_017026500.1XP_016881989.1  NAD-dependent protein deacetylase sirtuin-2 isoform X3

RNA

  1. XR_001753639.2 RNA Sequence

  2. XR_001753638.2 RNA Sequence

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p12 PATCHES

    Range
    288227..309534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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