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Sirt2 sirtuin 2 [ Mus musculus (house mouse) ]

Gene ID: 64383, updated on 24-Jan-2023

Summary

Official Symbol
Sirt2provided by MGI
Official Full Name
sirtuin 2provided by MGI
Primary source
MGI:MGI:1927664
See related
Ensembl:ENSMUSG00000015149 AllianceGenome:MGI:1927664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sir2l; SIR2L2; 5730427M03Rik
Summary
Enables beta-tubulin binding activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including positive regulation of cell cycle process; protein deacetylation; and regulation of transcription by RNA polymerase II. Acts upstream of or within histone deacetylation; negative regulation of NLRP3 inflammasome complex assembly; and regulation of fat cell differentiation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in early conceptus; eye; oocyte; otic pit; and trunk somite. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 56.8), cerebellum adult (RPKM 53.7) and 28 other tissues See more
Orthologs
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Genomic context

See Sirt2 in Genome Data Viewer
Location:
7; 7 B1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28466177..28488090)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28766752..28788665)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene seryl-aminoacyl-tRNA synthetase 2 Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Neighboring gene predicted gene, 19897 Neighboring gene nuclear encoded tRNA lysine 24 (anticodon TTT) Neighboring gene Ras and Rab interactor-like Neighboring gene heterogeneous nuclear ribonucleoprotein L

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent histone H4K16 deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD-dependent histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent protein demyristoylase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent protein depalmitoylase activity ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein lysine deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein lysine deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tubulin deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables tubulin deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of NLRP3 inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to caloric restriction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to epinephrine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H3 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H3 deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H4 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H4 deacetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within histone deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelination in peripheral nervous system ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of NLRP3 inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oligodendrocyte progenitor proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-lysine deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tubulin deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
located_in Schmidt-Lanterman incisure ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in glial cell projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
 
located_in lateral loop ISO
Inferred from Sequence Orthology
more info
 
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath abaxonal region ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in paranodal junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in paranodal junction ISO
Inferred from Sequence Orthology
more info
 
located_in paranode region of axon ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
located_in terminal loop ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-2
Names
NAD-dependent deacetylase sirtuin-2
NAD-dependent protein defatty-acylase sirtuin-2
SIR2-like protein 2
mSIR2L2
regulatory protein SIR2 homolog 2
silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2
NP_001116237.1
NP_001116238.1
NP_071877.3
XP_036009218.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122765.2NP_001116237.1  NAD-dependent protein deacetylase sirtuin-2 isoform 2

    See identical proteins and their annotated locations for NP_001116237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is 37 aa shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC171210
    Consensus CDS
    CCDS85253.1
    UniProtKB/Swiss-Prot
    Q8VDQ8
    Related
    ENSMUSP00000147217.2, ENSMUST00000122915.8
    Conserved Domains (1) summary
    cd01408
    Location:40294
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  2. NM_001122766.2NP_001116238.1  NAD-dependent protein deacetylase sirtuin-2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple in-frame exons in the 5' coding region, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC171210
    Consensus CDS
    CCDS52165.1
    UniProtKB/Swiss-Prot
    Q8VDQ8
    UniProtKB/TrEMBL
    A0A8C6HWG2
    Related
    ENSMUSP00000132783.2, ENSMUST00000170068.9
    Conserved Domains (1) summary
    cd01408
    Location:7261
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  3. NM_022432.5NP_071877.3  NAD-dependent protein deacetylase sirtuin-2 isoform 1

    See identical proteins and their annotated locations for NP_071877.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC171210
    Consensus CDS
    CCDS21055.1
    UniProtKB/Swiss-Prot
    Q8VDQ8, U5TP50
    Related
    ENSMUSP00000072732.5, ENSMUST00000072965.5
    Conserved Domains (1) summary
    cd01408
    Location:77331
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28466177..28488090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153325.1XP_036009218.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

    Conserved Domains (1) summary
    cd01408
    Location:40294
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...