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Sirt2 sirtuin 2 [ Mus musculus (house mouse) ]

Gene ID: 64383, updated on 12-Aug-2018
Official Symbol
Sirt2provided by MGI
Official Full Name
sirtuin 2provided by MGI
Primary source
MGI:MGI:1927664
See related
Ensembl:ENSMUSG00000015149 Vega:OTTMUSG00000017294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sir2l; SIR2L2; 5730427M03Rik
Expression
Ubiquitous expression in testis adult (RPKM 56.8), cerebellum adult (RPKM 53.7) and 28 other tissues See more
Orthologs
See Sirt2 in Genome Data Viewer
Location:
7; 7 B1
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (28766662..28788665)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (29551771..29573684)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene seryl-aminoacyl-tRNA synthetase 2 Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Neighboring gene predicted gene, 19897 Neighboring gene nuclear encoded tRNA lysine 24 (anticodon TTT) Neighboring gene Ras and Rab interactor-like Neighboring gene heterogeneous nuclear ribonucleoprotein L

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ binding ISO
Inferred from Sequence Orthology
more info
 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
NAD-dependent histone deacetylase activity (H4-K16 specific) ISO
Inferred from Sequence Orthology
more info
 
NAD-dependent protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
beta-tubulin binding IDA
Inferred from Direct Assay
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
tubulin deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
tubulin deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to caloric restriction IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to epinephrine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
histone H3 deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H3 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3 deacetylation ISO
Inferred from Sequence Orthology
more info
 
histone H4 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H4 deacetylation ISO
Inferred from Sequence Orthology
more info
 
histone deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
myelination in peripheral nervous system ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NLRP3 inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oligodendrocyte progenitor proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine deacetylation ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
ripoptosome assembly involved in necroptotic process IMP
Inferred from Mutant Phenotype
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
tubulin deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
Schmidt-Lanterman incisure ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
centriole ISO
Inferred from Sequence Orthology
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
chromosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
glial cell projection ISO
Inferred from Sequence Orthology
more info
 
juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
 
lateral loop ISO
Inferred from Sequence Orthology
more info
 
meiotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
midbody ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
myelin sheath abaxonal region ISO
Inferred from Sequence Orthology
more info
 
nuclear heterochromatin ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
paranodal junction IDA
Inferred from Direct Assay
more info
PubMed 
paranodal junction ISO
Inferred from Sequence Orthology
more info
 
paranode region of axon ISO
Inferred from Sequence Orthology
more info
 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
spindle ISO
Inferred from Sequence Orthology
more info
 
terminal loop ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
NAD-dependent protein deacetylase sirtuin-2
Names
NAD-dependent deacetylase sirtuin-2
SIR2-like protein 2
mSIR2L2
regulatory protein SIR2 homolog 2
silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2
NP_001116237.1
NP_001116238.1
NP_071877.3
XP_017167703.1
XP_017167704.1
XP_017167705.1
XP_017167706.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122765.1NP_001116237.1  NAD-dependent protein deacetylase sirtuin-2 isoform 2

    See identical proteins and their annotated locations for NP_001116237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is 37 aa shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK014042, BB772353, BB873718
    Consensus CDS
    CCDS85253.1
    UniProtKB/Swiss-Prot
    Q8VDQ8
    Related
    ENSMUSP00000147217.1, OTTMUSP00000075499, ENSMUST00000122915.7, OTTMUST00000041938
    Conserved Domains (1) summary
    cd01408
    Location:40294
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  2. NM_001122766.1NP_001116238.1  NAD-dependent protein deacetylase sirtuin-2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple in-frame exons in the 5' coding region, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK014042, BB772353, BB868649, BB873718
    Consensus CDS
    CCDS52165.1
    UniProtKB/Swiss-Prot
    Q8VDQ8
    Related
    ENSMUSP00000132783.1, OTTMUSP00000075500, ENSMUST00000170068.8, OTTMUST00000144902
    Conserved Domains (1) summary
    cd01408
    Location:7261
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  3. NM_022432.4NP_071877.3  NAD-dependent protein deacetylase sirtuin-2 isoform 1

    See identical proteins and their annotated locations for NP_071877.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF299337, AK014042, BB772353, BB873718
    Consensus CDS
    CCDS21055.1
    UniProtKB/Swiss-Prot
    Q8VDQ8
    Related
    ENSMUSP00000072732.4, OTTMUSP00000018858, ENSMUST00000072965.4, OTTMUST00000041937
    Conserved Domains (1) summary
    cd01408
    Location:77331
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    28766662..28788665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312214.1XP_017167703.1  NAD-dependent protein deacetylase sirtuin-2 isoform X1

  2. XM_017312217.1XP_017167706.1  NAD-dependent protein deacetylase sirtuin-2 isoform X4

  3. XM_017312215.1XP_017167704.1  NAD-dependent protein deacetylase sirtuin-2 isoform X2

  4. XM_017312216.1XP_017167705.1  NAD-dependent protein deacetylase sirtuin-2 isoform X3

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