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BAHD1 bromo adjacent homology domain containing 1 [ Homo sapiens (human) ]

Gene ID: 22893, updated on 26-Oct-2022

Summary

Official Symbol
BAHD1provided by HGNC
Official Full Name
bromo adjacent homology domain containing 1provided by HGNC
Primary source
HGNC:HGNC:29153
See related
Ensembl:ENSG00000140320 MIM:613880; AllianceGenome:HGNC:29153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables chromatin binding activity. Involved in heterochromatin assembly and negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 12.0), ovary (RPKM 8.8) and 25 other tissues See more
Orthologs
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Genomic context

See BAHD1 in Genome Data Viewer
Location:
15q15.1
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40437452..40468236)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38247131..38275586)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40731956..40760435)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene kinetochore localized astrin (SPAG5) binding protein Neighboring gene isovaleryl-CoA dehydrogenase Neighboring gene uncharacterized LOC124903473 Neighboring gene carbohydrate sulfotransferase 14 Neighboring gene ribosomal protein L9 pseudogene 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of bromo adjacent homology domain containing 1 (BAHD1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0945

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin silencing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
bromo adjacent homology domain-containing 1 protein
Names
BAH domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301132.2NP_001288061.1  bromo adjacent homology domain-containing 1 protein isoform b

    See identical proteins and their annotated locations for NP_001288061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
    Source sequence(s)
    AB023162, AC013356, BU740533
    Consensus CDS
    CCDS73705.1
    UniProtKB/Swiss-Prot
    Q8TBE0
    Related
    ENSP00000454150.1, ENST00000561234.5
    Conserved Domains (2) summary
    cd04714
    Location:622732
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    cl26464
    Location:170552
    Atrophin-1; Atrophin-1 family
  2. NM_001411044.1NP_001397973.1  bromo adjacent homology domain-containing 1 protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC013356
    Consensus CDS
    CCDS91980.1
  3. NM_014952.5NP_055767.3  bromo adjacent homology domain-containing 1 protein isoform a

    See identical proteins and their annotated locations for NP_055767.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AB023162, AC013356, BC022782, BU740533, HY041603
    Consensus CDS
    CCDS10058.1
    UniProtKB/Swiss-Prot
    Q8TBE0, Q9Y2F4
    UniProtKB/TrEMBL
    A0A024R9K2
    Related
    ENSP00000396976.1, ENST00000416165.6
    Conserved Domains (1) summary
    cd04714
    Location:623733
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

RNA

  1. NR_125372.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the central region and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC013356, BC022782, BU740533, HY041603, HY353002

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    40437452..40468236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432244.1XP_047288200.1  bromo adjacent homology domain-containing 1 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9Y2F4
    UniProtKB/TrEMBL
    A0A024R9K2
  2. XM_011521369.4XP_011519671.1  bromo adjacent homology domain-containing 1 protein isoform X7

    See identical proteins and their annotated locations for XP_011519671.1

    UniProtKB/Swiss-Prot
    Q8TBE0, Q9Y2F4
    UniProtKB/TrEMBL
    A0A024R9K2
    Conserved Domains (1) summary
    cd04714
    Location:623733
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
  3. XM_047432245.1XP_047288201.1  bromo adjacent homology domain-containing 1 protein isoform X7

    UniProtKB/Swiss-Prot
    Q9Y2F4
    UniProtKB/TrEMBL
    A0A024R9K2
  4. XM_047432242.1XP_047288198.1  bromo adjacent homology domain-containing 1 protein isoform X5

  5. XM_047432247.1XP_047288203.1  bromo adjacent homology domain-containing 1 protein isoform X9

  6. XM_047432246.1XP_047288202.1  bromo adjacent homology domain-containing 1 protein isoform X8

  7. XM_047432248.1XP_047288204.1  bromo adjacent homology domain-containing 1 protein isoform X9

    Related
    ENSP00000454101.1, ENST00000560846.1
  8. XM_047432249.1XP_047288205.1  bromo adjacent homology domain-containing 1 protein isoform X10

  9. XM_047432243.1XP_047288199.1  bromo adjacent homology domain-containing 1 protein isoform X6

  10. XM_011521367.4XP_011519669.2  bromo adjacent homology domain-containing 1 protein isoform X2

  11. XM_047432241.1XP_047288197.1  bromo adjacent homology domain-containing 1 protein isoform X4

  12. XM_011521366.3XP_011519668.2  bromo adjacent homology domain-containing 1 protein isoform X1

  13. XM_011521368.3XP_011519670.2  bromo adjacent homology domain-containing 1 protein isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    38247131..38275586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)