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ZNF365 zinc finger protein 365 [ Homo sapiens (human) ]

Gene ID: 22891, updated on 6-May-2021

Summary

Official Symbol
ZNF365provided by HGNC
Official Full Name
zinc finger protein 365provided by HGNC
Primary source
HGNC:HGNC:18194
See related
Ensembl:ENSG00000138311 MIM:607818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UAN; Su48; ZNF365D
Summary
This gene encodes a zinc finger protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast cancer susceptibility. [provided by RefSeq, Mar 2020]
Expression
Biased expression in brain (RPKM 9.2), esophagus (RPKM 2.1) and 3 other tissues See more
Orthologs
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Genomic context

See ZNF365 in Genome Data Viewer
Location:
10q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (62374369..62544262)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (64134128..64240044)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2621 Neighboring gene uncharacterized LOC283045 Neighboring gene RNA, 7SL, cytoplasmic 591, pseudogene Neighboring gene uncharacterized LOC105378327 Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A Genome-wide Association Study of Autism Using the Simons Simplex Collection: Does Reducing Phenotypic Heterogeneity in Autism Increase Genetic Homogeneity?
GeneReviews: Not available
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
GeneReviews: Not available
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
GeneReviews: Not available
Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
GeneReviews: Not available
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
GeneReviews: Not available
Genetic variants associated with breast size also influence breast cancer risk.
GeneReviews: Not available
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
GeneReviews: Not available
Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3.
GeneReviews: Not available
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
GeneReviews: Not available
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
GeneReviews: Not available
Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium.
GeneReviews: Not available
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
GeneReviews: Not available
Genome-wide association study identifies five new breast cancer susceptibility loci.
GeneReviews: Not available
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
GeneReviews: Not available
Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
GeneReviews: Not available
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
GeneReviews: Not available
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
GeneReviews: Not available
Uric acid nephrolithiasis, susceptibility to
MedGen: C2700426 OMIM: 605990 GeneReviews: Not available
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Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0844, MGC41821, MGC87345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein ZNF365
Names
DISC1-binding zinc-finger protein
protein su48
talanin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021209.2 RefSeqGene

    Range
    5178..33259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014951.3NP_055766.2  protein ZNF365 isoform A

    See identical proteins and their annotated locations for NP_055766.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) differs in the 3' coding region and UTR compared to variant C. The resulting protein (isoform A) is shorter and has a distinct C-terminus compared to isoform C.
    Source sequence(s)
    AB020651, AC024598, BC017841, BC060817
    Consensus CDS
    CCDS31209.1
    UniProtKB/Swiss-Prot
    Q70YC5
    Related
    ENSP00000378674.3, ENST00000395254.8
    Conserved Domains (1) summary
    PRK00286
    Location:159314
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
  2. NM_199450.3NP_955522.1  protein ZNF365 isoform B

    See identical proteins and their annotated locations for NP_955522.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 3' coding region and UTR compared to variant C. The resulting protein (isoform B) is shorter and has a distinct C-terminus compared to isoform C.
    Source sequence(s)
    AJ505148, BC017841, BF512570
    Consensus CDS
    CCDS41531.1
    UniProtKB/Swiss-Prot
    Q70YC5
    Related
    ENSP00000378675.3, ENST00000395255.7
    Conserved Domains (1) summary
    TIGR02168
    Location:177290
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    62374369..62544262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015937.2XP_016871426.1  protein ZNF365 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199451.3: Suppressed sequence

    Description
    NM_199451.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
  2. NM_199452.3: Suppressed sequence

    Description
    NM_199452.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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