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Zfp365 zinc finger protein 365 [ Mus musculus (house mouse) ]

Gene ID: 216049, updated on 5-Mar-2024

Summary

Official Symbol
Zfp365provided by MGI
Official Full Name
zinc finger protein 365provided by MGI
Primary source
MGI:MGI:2143676
See related
Ensembl:ENSMUSG00000037855 AllianceGenome:MGI:2143676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DBZ; Su48; Znf365; talanin
Summary
Predicted to enable protein homodimerization activity. Involved in nervous system development and telomere maintenance. Predicted to be located in centrosome and intracellular membrane-bounded organelle. Predicted to be active in centriolar satellite. Is expressed in brain; embryo; and lens. Human ortholog(s) of this gene implicated in uric acid nephrolithiasis. Orthologous to human ZNF365 (zinc finger protein 365). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 80.2), frontal lobe adult (RPKM 65.7) and 1 other tissue See more
Orthologs
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Genomic context

See Zfp365 in Genome Data Viewer
Location:
10 B5.1; 10 35.04 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (67721935..67748492, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (67886105..67912662, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930543I11 gene Neighboring gene predicted gene, 51769 Neighboring gene predicted gene, 29774 Neighboring gene STARR-seq mESC enhancer starr_27008 Neighboring gene STARR-seq mESC enhancer starr_27009 Neighboring gene STARR-seq mESC enhancer starr_27010 Neighboring gene RIKEN cDNA 4930521O17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5144 Neighboring gene rhotekin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in cerebellar molecular layer morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite arborization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gamma-tubulin complex localization ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA strand resection involved in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA strand resection involved in replication fork processing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein ZNF365
Names
DISC1-binding zinc-finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178679.2NP_848794.1  protein ZNF365

    See identical proteins and their annotated locations for NP_848794.1

    Status: VALIDATED

    Source sequence(s)
    AJ516033, BC080272, CB519185
    Consensus CDS
    CCDS23903.1
    UniProtKB/Swiss-Prot
    Q80TQ4, Q8BG89, Q8BK39, Q8BXT2
    UniProtKB/TrEMBL
    B2RXU5
    Related
    ENSMUSP00000067197.8, ENSMUST00000064656.8
    Conserved Domains (1) summary
    TIGR02168
    Location:178291
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    67721935..67748492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)