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Ddx27 DEAD box helicase 27 [ Mus musculus (house mouse) ]

Gene ID: 228889, updated on 21-Apr-2024

Summary

Official Symbol
Ddx27provided by MGI
Official Full Name
DEAD box helicase 27provided by MGI
Primary source
MGI:MGI:2385884
See related
Ensembl:ENSMUSG00000017999 AllianceGenome:MGI:2385884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be involved in rRNA processing. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human DDX27 (DEAD-box helicase 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 22.5), liver E14.5 (RPKM 21.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2 H3; 2 87.22 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166857233..166876865)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167015313..167034945)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene staufen double-stranded RNA binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9541 Neighboring gene GLE1 RNA export mediator pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2656 Neighboring gene zinc finger, NFX1-type containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6022 Neighboring gene predicted gene, 25878 Neighboring gene zinc finger, NFX1-type containing 1, antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX27
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
DEAD box protein 27
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 27
RNA-helicase like protein
NP_694705.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153065.3NP_694705.2  probable ATP-dependent RNA helicase DDX27

    See identical proteins and their annotated locations for NP_694705.2

    Status: PROVISIONAL

    Source sequence(s)
    AK134274
    Consensus CDS
    CCDS38336.1
    UniProtKB/Swiss-Prot
    Q3UUG2, Q8R0W3, Q8R1E2, Q921N6
    Related
    ENSMUSP00000018143.10, ENSMUST00000018143.16
    Conserved Domains (3) summary
    COG0513
    Location:175640
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00268
    Location:186390
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:415524
    Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    166857233..166876865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)